J Cancer 2017; 8(10):1759-1768. doi:10.7150/jca.17349

Research Paper

Survival changes in Patients with Synovial Sarcoma, 1983-2012

Shuncong Wang1*, Rongfeng Song2*, Tiantian Sun3, Bingzong Hou4, Guobin Hong5, Saradhi Mallampati6, Hongliu Sun7, Xiuling Zhou1, Cuiling Zhou1, Hongyu Zhang1, Zhibin Cheng1, Jie Li8, Haiqing Ma1✉, Huanhuan Sun1✉

1. Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China;
2. Department of Gastroenterology, Cancer Hospital of Jiangxi Province, Nanchang, Jiangxi 330029, China;
3. Department of Hematology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
4. Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China;
5. Department of Radiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong 519000, China;
6. Department of Laboratory Medicine and the Center for Stem Cell and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;
7. Department of pathology, University of Michigan, Ann Arbor, MI 48201, USA;
8. Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
*These authors contributed equally to this work.

Abstract

Background: Synovial sarcoma (SyS) is a rare malignancy that typically invades the extremities and occurs predominantly in adolescents. Studies on incidence and survival in SyS that were based on a large population had not been reported yet.

Methods: To evaluate changes in incidence and survival in SyS over three decades, we accessed data on SyS cases in each decade between 1983 and 2012 (1983-1992, 1993-2002, and 2003-2012) from the Surveillance, Epidemiology, and End Results (SEER) database. The survival difference between decades, age groups, sexes, race, pathologic types, sites, stages and socioeconomic status (SES) over three decades were accessed by comparing Kaplan-Meier curves.

Results: We located 2,070 SyS cases in 18 SEER registry regions between 1983 and 2012. Our study demonstrated that the incidence of SyS per 1,000,000 continued to increase from 0.906 to 1.348 to 1.548 in the total population and in most age groups and that the age of incidence peak was 15-29 years in three decades. But, the survival of patients with SyS did not significantly improve throughout the three decades, with 5-year survival rates of 69.4%, 61.1% and 60.5% respectively (p > 0.05). Interestingly, the widening survival gaps among races, sexes, pathological types and various SES over time were observed, with narrowing p values.

Conclusions: This study demonstrated the increasing incidence and unimproved survival rates across three decades in a large sample, indicating the urgency for further development of diagnosis, improving health care providers' awareness of SyS and lead to the development of novel treatments.

Keywords: synovial sarcoma, incidence, survival, sites and stages

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How to cite this article:
Wang S, Song R, Sun T, Hou B, Hong G, Mallampati S, Sun H, Zhou X, Zhou C, Zhang H, Cheng Z, Li J, Ma H, Sun H. Survival changes in Patients with Synovial Sarcoma, 1983-2012. J Cancer 2017; 8(10):1759-1768. doi:10.7150/jca.17349. Available from http://www.jcancer.org/v08p1759.htm