J Cancer 2017; 8(13):2492-2500. doi:10.7150/jca.19601

Review

Chromosomal and Genomic Variations in Esophageal Squamous Cell Carcinoma: A Review of Technologies, Applications, and Prospections

Qi Song1, Dongxian Jiang1, Haixing Wang1, Jie Huang1, Yalan Liu1, Chen Xu1, Yingyong Hou1, 2✉

1. Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;
2. Department of Pathology, School of Basic Medical Sciences & Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China.

Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor prognosis worldwide. The poor prognosis is due to the advanced stage at the time of diagnosis and the limited clinical staging lacking significant molecular biomarkers to effectively stratify patients for treatment options. As cancer is a disease of genome instability and a resulting of accumulation of genetic alteration, mounting chromosomal and genomic technologies were developed and progressed rapidly which could be used for characterizing patients in genomics level. In this review, we summarized applications of multiple technologies and research progress at chromosomal and genomic level in ESCC.

Keywords: esophageal squamous cell carcinoma, chromosomal, genomic, technology, application.

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How to cite this article:
Song Q, Jiang D, Wang H, Huang J, Liu Y, Xu C, Hou Y. Chromosomal and Genomic Variations in Esophageal Squamous Cell Carcinoma: A Review of Technologies, Applications, and Prospections. J Cancer 2017; 8(13):2492-2500. doi:10.7150/jca.19601. Available from http://www.jcancer.org/v08p2492.htm