J Cancer 2018; 9(9):1598-1606. doi:10.7150/jca.24310

Research Paper

A Multicenter Retrospective Comparison of Sequential versus Sandwich Chemoradiotherapy for Stage IE-IIE Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

Jin Li1, Yajun Li 1,2, Meizuo Zhong3, Wei Liu3, Xianling Liu4, Jiwei Li1, Kunlun Li1, Pingyong Yi1,2,✉

1. Department of Lymphoma and Hematology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China, 410013.
2. Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, Hunan, China, 410013.
3. Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China, 410008.
4. Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China, 410011.

Abstract

Background: Chemotherapy and radiotherapy are critical for treating early-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL); however, the optimal therapy sequence remains unclear. Therefore, we performed this study to compare the efficacy of L-asparaginase/pegaspargase-based sequential versus sandwich chemoradiotherapy for patients newly diagnosed with stage IE-IIE ENKTL.

Methods: Patients were categorized into sequential (N = 111) and sandwich (N = 104) groups. Chemotherapy regimens included GELOX, SMILE, and VLP. The median radiotherapy dose was 55.0 Gy (range, 40.0-63.0 Gy). Adverse events, treatment responses, and survival outcomes were analyzed.

Results: Patients' clinical characteristics were largely comparable between the 2 groups; however, the sandwich group comprised a larger number of Ann Arbor stage IIE patients. Local invasion was the most significant predictor of overall survival (OS); local invasion and Ann Arbor stage were significant predictors of progression-free survival (PFS). There were no significant differences in the complete response rate (85.6% vs. 89.4%, p = 0.396), 3-year OS (77.5% vs. 80.8%, p = 0.636), or 3-year PFS rates (74.8% vs. 76.9%, p = 0.806) in the sequential vs. sandwich groups, respectively. The incidence of grade 3/4 hematological toxicities was higher in the sandwich group than in the sequential group (27.9% vs. 15.3%, respectively, p = 0.025). The response rates and survival outcomes in stage IE and IIE patients did not differ between sequential and sandwich groups.

Conclusions: In the era of L-asparaginase/pegaspargase, both sequential and sandwich chemoradiotherapy are safe and similarly effective in patients with newly diagnosed stage IE-IIE ENKTL.

Keywords: Extranodal natural killer/T-cell lymphoma, nasal type, sequential chemoradiotherapy, sandwich chemoradiotherapy

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How to cite this article:
Li J, Li Y, Zhong M, Liu W, Liu X, Li J, Li K, Yi P. A Multicenter Retrospective Comparison of Sequential versus Sandwich Chemoradiotherapy for Stage IE-IIE Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type. J Cancer 2018; 9(9):1598-1606. doi:10.7150/jca.24310. Available from http://www.jcancer.org/v09p1598.htm