J Cancer
2018; 9(18):3343-3351.
doi:10.7150/jca.25515 This issueCite
Research Paper
Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls
Xi Gu#, Jiaxi Feng#, Liyang Liu#, Ming Lu, Xiang Ma, Yang Cao, Baolin Wang, Qinghong Zhao✉
Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China # Equal contributors and co-first authors.
✉ Corresponding author: Qinghong Zhao, Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjia Yuan Road, Nanjing 210011, Jiangsu, Chia. E-mail: njzhqhcom
Citation:
Gu X, Feng J, Liu L, Lu M, Ma X, Cao Y, Wang B, Zhao Q. Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls. J Cancer 2018; 9(18):3343-3351. doi:10.7150/jca.25515. https://www.jcancer.org/v09p3343.htm
Objectives: The result of the relationship between the MUC1 rs4072037 polymorphism and cancer risk is controversial, we take this meta-analysis to investigate a more precise result.
Methods: Electronic database Pubmed, Web of science and Cochrane library had been used to search relevant articles concerning the relationship between MUC1 rs4072037 polymorphism and cancer risk. We used odds ratios (ORs) and 95% confidence intervals (CIs) to assess the strength of the gene-disease association. We also conducted subgroup analysis, sensitivity analyses and publication bias in the meta-analysis.
Results: In our meta-analysis, we involved 17 studies (19 datasets) with 12551 cases and 13436 controls eventually. It showed the MUC1 rs4072037 polymorphism was associated with decreased cancer risk in four genetic models (G vs. A: OR=0.79, 95%CI: 0.71-0.89, P< 0.001; AG vs. AA: OR=0.72, 95%CI: 0.62-0.82, P< 0.001; GG vs. AA: OR=0.78, 95%CI: 0.69-0.88, P< 0.001; AG+GG vs. AA: OR=0.72, 95%CI: 0.63-0.83, P< 0.001). In subgroup analysis, it showed a decreased cancer risk among Asians but not Caucasians and a significant decreased gastric cancer risk in all genetic models.
Conclusion: MUC1 rs4072037 polymorphism is associated with decreased cancer risk and can probably be used as a tumor marker, especially for gastric cancer and for Asians.
Gu, X., Feng, J., Liu, L., Lu, M., Ma, X., Cao, Y., Wang, B., Zhao, Q. (2018). Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls. Journal of Cancer, 9(18), 3343-3351. https://doi.org/10.7150/jca.25515.
ACS
Gu, X.; Feng, J.; Liu, L.; Lu, M.; Ma, X.; Cao, Y.; Wang, B.; Zhao, Q. Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls. J. Cancer 2018, 9 (18), 3343-3351. DOI: 10.7150/jca.25515.
NLM
Gu X, Feng J, Liu L, Lu M, Ma X, Cao Y, Wang B, Zhao Q. Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls. J Cancer 2018; 9(18):3343-3351. doi:10.7150/jca.25515. https://www.jcancer.org/v09p3343.htm
CSE
Gu X, Feng J, Liu L, Lu M, Ma X, Cao Y, Wang B, Zhao Q. 2018. Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls. J Cancer. 9(18):3343-3351.
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