J Cancer 2019; 10(2):313-322. doi:10.7150/jca.26882 This issue Cite

Research Paper

Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching

Xiao Li1,2, Bang An3, Jincai Ma1,4, Bo He1,2, Jianni Qi2,5, Wenwen Wang1,2, Chengyong Qin1,2,6, Qi Zhao1,2✉

1. Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China;
2. Shandong Provincial Engineering and Technological Research Center for Liver Diseases Prevention and Control, Jinan 250021, Shandong Province, China;
3. Department of Cardiology, Central Hospital of Zibo, Zibo 255036, Shandong Province, China;
4. Department of Gastroenterology, The Fifth People's Hospital of Jinan, Jinan 250022, Shandong Province, China;
5. Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong Province, China;
6. Health Commission of Shandong Province, Jinan 250014, Shandong Province, China.

Citation:
Li X, An B, Ma J, He B, Qi J, Wang W, Qin C, Zhao Q. Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching. J Cancer 2019; 10(2):313-322. doi:10.7150/jca.26882. https://www.jcancer.org/v10p0313.htm
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Abstract

Objective: To investigate the prognostic value of the tumor size in colorectal cancer (CRC) patients with different primary tumor locations.

Patients and methods: We retrospectively recruited 3971 stage I-III CRC patients with curative resection. The propensity score matching technique was conducted to reduce the selection bias, producing a propensity score matched cohort of 1347 pairs of patients based on the tumor size (≤4 cm and >4 cm groups). Kaplan-Meier survival analyses and univariate and multivariate analyses were used to compare the overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) between the two groups. Subgroup analyses which were stratified by primary tumor locations and several other baseline variables were also performed for conformation.

Results: In the propensity score matched cohort, the Kaplan-Meier survival curves revealed that patients with a tumor size less than 4 cm had similar OS, CSS and DFS, compared to patients with a tumor size greater than 4 cm. While in multivariate analyses, the smaller tumor size was an independent risk factor for CSS (HR, 1.275; 95% CI, 1.006-1.616; P=0.045). Subgroup analyses based on primary tumor locations further suggested that the smaller tumor size was significantly associated with worse OS (HR, 2.455; 95% CI, 1.297-4.649; P=0.006) and CSS (HR, 2.493; 95% CI, 1.202-5.174; P=0.014) in patients with right-side colon cancers (RCC).

Conclusions: Our propensity matching score study indicated that the smaller tumor size was an independent risk factor for CSS in patients with stage I-III CRC, and for OS and CSS in patients with RCC.

Keywords: tumor size, primary tumor location, colorectal cancer, prognosis, propensity score matching


Citation styles

APA
Li, X., An, B., Ma, J., He, B., Qi, J., Wang, W., Qin, C., Zhao, Q. (2019). Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching. Journal of Cancer, 10(2), 313-322. https://doi.org/10.7150/jca.26882.

ACS
Li, X.; An, B.; Ma, J.; He, B.; Qi, J.; Wang, W.; Qin, C.; Zhao, Q. Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching. J. Cancer 2019, 10 (2), 313-322. DOI: 10.7150/jca.26882.

NLM
Li X, An B, Ma J, He B, Qi J, Wang W, Qin C, Zhao Q. Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching. J Cancer 2019; 10(2):313-322. doi:10.7150/jca.26882. https://www.jcancer.org/v10p0313.htm

CSE
Li X, An B, Ma J, He B, Qi J, Wang W, Qin C, Zhao Q. 2019. Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching. J Cancer. 10(2):313-322.

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