J Cancer 2021; 12(10):2807-2814. doi:10.7150/jca.51445 This issue Cite

Research Paper

The relationship between the severity of pulmonary fibrosis and the lung cancer stage

Hye Jin Jang1, Moo Suk Park1, Young Sam Kim1, Joon Chang1, Jae Ho Lee2, Choon-Taek Lee2, Sang Hoon Lee1✉, Ho Il Yoon2✉

1. Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea.

Citation:
Jang HJ, Park MS, Kim YS, Chang J, Lee JH, Lee CT, Lee SH, Yoon HI. The relationship between the severity of pulmonary fibrosis and the lung cancer stage. J Cancer 2021; 12(10):2807-2814. doi:10.7150/jca.51445. https://www.jcancer.org/v12p2807.htm
Other styles

File import instruction

Abstract

Graphic abstract

Background: The incidence of idiopathic pulmonary fibrosis (IPF) and mortality related to the disease have steadily increased in recent years. The risk of cancer is approximately eight times higher in IPF patients than in the general population. The purpose of this study is to determine whether the severity of IPF is related to the time interval between IPF diagnosis and lung cancer diagnosis and to the stage of lung cancer at diagnosis.

Methods: In this retrospective cohort study, we reviewed the medical records of patients with lung cancer after IPF diagnosis from two tertiary hospitals in South Korea between 2003 and 2018. We identified 61 patients diagnosed with lung cancer at least 3 months after being diagnosed with IPF.

Results: The included patients had a mean age of 71.0 years, and all but one were men (98.4%). The interval between IPF diagnosis and lung cancer diagnosis was not related to the gender-age-physiology (GAP) stage (p=0.662). However, in cox proportional hazard models, a higher GAP stage was significantly correlated with an advanced lung cancer stage (odds ratio 11.1, p=0.003).

Conclusions: The lung cancer stage at diagnosis was higher in patients with a higher GAP stage than in those with a lower GAP stage. Physicians should consider implementing more frequent surveillance with computed tomography scans for patients with advanced IPF.

Keywords: idiopathic pulmonary fibrosis, lung cancer, GAP stage


Citation styles

APA
Jang, H.J., Park, M.S., Kim, Y.S., Chang, J., Lee, J.H., Lee, C.T., Lee, S.H., Yoon, H.I. (2021). The relationship between the severity of pulmonary fibrosis and the lung cancer stage. Journal of Cancer, 12(10), 2807-2814. https://doi.org/10.7150/jca.51445.

ACS
Jang, H.J.; Park, M.S.; Kim, Y.S.; Chang, J.; Lee, J.H.; Lee, C.T.; Lee, S.H.; Yoon, H.I. The relationship between the severity of pulmonary fibrosis and the lung cancer stage. J. Cancer 2021, 12 (10), 2807-2814. DOI: 10.7150/jca.51445.

NLM
Jang HJ, Park MS, Kim YS, Chang J, Lee JH, Lee CT, Lee SH, Yoon HI. The relationship between the severity of pulmonary fibrosis and the lung cancer stage. J Cancer 2021; 12(10):2807-2814. doi:10.7150/jca.51445. https://www.jcancer.org/v12p2807.htm

CSE
Jang HJ, Park MS, Kim YS, Chang J, Lee JH, Lee CT, Lee SH, Yoon HI. 2021. The relationship between the severity of pulmonary fibrosis and the lung cancer stage. J Cancer. 12(10):2807-2814.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image