J Cancer 2021; 12(13):4011-4024. doi:10.7150/jca.51303 This issue Cite

Research Paper

Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression

Yi Shen1*, Xiaolei Dai2*, Haibo Chen1*, Shuwei Zhai1, Qiliang Peng3,4, Shang Cai3,4, Yaqun Zhu3,4, Jian Huan1, Yuntian Shen3,4✉

1. Department of Radiation Oncology, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou, China.
2. Department of General Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine.
3. Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
4. Institute of Radiotherapy & Oncology, Soochow University, Suzhou, China.
*These authors contributed equally to this work.

Citation:
Shen Y, Dai X, Chen H, Zhai S, Peng Q, Cai S, Zhu Y, Huan J, Shen Y. Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. J Cancer 2021; 12(13):4011-4024. doi:10.7150/jca.51303. https://www.jcancer.org/v12p4011.htm
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Abstract

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Background: Digestive system cancers (DSCs) have been recognized to be linked with high morbidity and mortality. Recent studies have reported that microRNA-10b (miR-10b) is abnormally expressed in DSCs and associated with prognosis. However, the inconclusive results and unknown underlying mechanisms promoted us to perform this study.

Methods: We systematic searched several databases for eligible studies and conducted quantitative analysis for evidence regarding the associations between miR-10b and survival outcome of DSCs. We also performed a series of bioinformatics analyses to uncover the potential mechanisms.

Results: A total of 32 eligible studies with 3392 patients were included. Increased miR-10b expression was linked with unfavorable overall survival (OS) in DSCs (HR=1.72; 95% CI: 1.30-2.27; P <0.001). When stratified by tumor type, the impact of miR-10b overexpression on poor prognosis was observed in colorectal cancer, gastric cancer, hepatocellular carcinoma, and esophageal carcinoma, but not in pancreatic cancer. Subsequently, we predicted the targets of miR-10b and conducted functional enrichment analyses. The results disclosed that miR-10b targets were predominantly enriched in some vital biological terms and pivotal signaling pathways associated with tumor progression including cell cycle, FoxO, proteoglycans, central carbon metabolism, p53, Notch, HIF-1, focal adhesion, AMPK, and pancreatic cancer. Moreover, a protein-protein interaction (PPI) network was also constructed to identify the top ten hub genes and significant modules and demonstrated the underlying interactions among them.

Conclusion: Our results indicated that miR-10b could act as a significant biomarker in the prognosis DSCs. However, more research should be performed to test these findings.

Keywords: digestive system cancers, microRNA-10b, prognosis prediction, biomarker


Citation styles

APA
Shen, Y., Dai, X., Chen, H., Zhai, S., Peng, Q., Cai, S., Zhu, Y., Huan, J., Shen, Y. (2021). Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. Journal of Cancer, 12(13), 4011-4024. https://doi.org/10.7150/jca.51303.

ACS
Shen, Y.; Dai, X.; Chen, H.; Zhai, S.; Peng, Q.; Cai, S.; Zhu, Y.; Huan, J.; Shen, Y. Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. J. Cancer 2021, 12 (13), 4011-4024. DOI: 10.7150/jca.51303.

NLM
Shen Y, Dai X, Chen H, Zhai S, Peng Q, Cai S, Zhu Y, Huan J, Shen Y. Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. J Cancer 2021; 12(13):4011-4024. doi:10.7150/jca.51303. https://www.jcancer.org/v12p4011.htm

CSE
Shen Y, Dai X, Chen H, Zhai S, Peng Q, Cai S, Zhu Y, Huan J, Shen Y. 2021. Comprehensive evaluation of microRNA-10b in digestive system cancers reveals prognostic implication and signaling pathways associated with tumor progression. J Cancer. 12(13):4011-4024.

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