J Cancer 2012; 3:14-18. doi:10.7150/jca.3.14

Case Report

Endometrioid Adenocarcinoma with High-Grade Transformation with Serous and Choriocarcinomatous Differentiation - A Case Report

Senn Wakahashi1, Tamotsu Sudo1,2,✉, Eriko Nakagawa1, Sayaka Ueno1, Miho Muraji1, Seiji Kanayama1, Hiroe Itami3, Fumi Kawakami3, Takashi Yamada1, Satoshi Yamaguchi1, Kiyoshi Fujiwara1, Hironobu Nishikawa4, Ryuichiro Nishimura1, Chiho Ohbayashi3

1. Department of Gynecologic Oncology, Hyogo Cancer Center, 13-70 Kita-Oji, Akashi, Hyogo 673-8558, Japan.
2. Section of Translational Research, Hyogo Cancer Center, 13-70 Kita-Oji, Akashi, Hyogo 673-8558, Japan.
3. Department of Diagnostic Pathology, Hyogo Cancer Center, 13-70 Kita-Oji, Akashi, Hyogo 673-8558, Japan.
4. Department of Surgery, Mitsu Municipal Hospital, 1666 Nakashima, Mitsu, Tatsuno, Hyogo 671-1311, Japan.

Abstract

A choriocarcinoma component with a malignant tumor is relatively rare. We present a case of an 85-year-old woman with mixed carcinoma, which was endometrioid adenocarcinoma with squamous differentiation, choriocarcinoma and a disseminated peritoneal nodule, which was papillary serous adenocarcinoma. The patient received surgery and conservative treatment. Twenty weeks after surgery, a recurring tumor appeared at the Douglas pouch. Histology showed that the recurring tumor was poorly differentiated carcinoma that was very different from the primary tumor. This case represents an unusual uterine corpus cancer with high-grade transformation with serous and choriocarcinomatous differentiation. This case also demonstrates the capacity of tumor cells to differentiate into divergent elements.

Keywords: hCG, choriocarcinoma, endometrial cancer, squamous cell carcinoma, trophoblastic tumor.

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How to cite this article:
Wakahashi S, Sudo T, Nakagawa E, Ueno S, Muraji M, Kanayama S, Itami H, Kawakami F, Yamada T, Yamaguchi S, Fujiwara K, Nishikawa H, Nishimura R, Ohbayashi C. Endometrioid Adenocarcinoma with High-Grade Transformation with Serous and Choriocarcinomatous Differentiation - A Case Report. J Cancer 2012; 3:14-18. doi:10.7150/jca.3.14. Available from http://www.jcancer.org/v03p0014.htm