Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
FOLFIRINOX in Locally Advanced and Metastatic Pancreatic Cancer: A Single Centre Cohort Study
SJ Rombouts, TH Mungroop, MN Heilmann, HW van Laarhoven, OR Busch, IQ Molenaar, MG Besselink, JW Wilmink
J. Cancer 2016; 7(13): 1861-1866. doi:10.7150/jca.16279
[Abstract] [Full text] [PDF]

Short Research Communication
Low Proteolytic Clipping of Histone H3 in Cervical Cancer
Jorge Sandoval-Basilio, Nicolás Serafín-Higuera, Octavio D. Reyes-Hernandez, Idanya Serafín-Higuera, Gabriela Leija-Montoya, Magali Blanco-Morales, Monica Sierra-Martínez, Roberto Ramos-Mondragon, Silvia García, Luz Berenice López-Hernández, Martha Yocupicio-Monroy, Sofia L. Alcaraz-Estrada
J. Cancer 2016; 7(13): 1856-1860. doi:10.7150/jca.15605
[Abstract] [Full text] [PDF]

Review
Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation
Jiajia Chen, Zhijun Miao, Boxin Xue, Yuxi Shan, Guobin Weng, Bairong Shen
J. Cancer 2016; 7(13): 1842-1855. doi:10.7150/jca.15876
[Abstract] [Full text] [PDF]

Research Paper
Validation and Comparison of the 7th Edition of the American Joint Committee on Cancer Staging System and Other Prognostic Models to Predict Relapse-Free Survival in Asian Patients with Parotid Cancer
Chang-Hsien Lu, Chien-Ting Liu, Pei-Hung Chang, Kun-Yun Yeh, Chia-Yen Hung, Shau-Hsuan Li, Yung-Chang Lin, Ta-Sen Yeh, Yung-Shin Hung, Wen-Chi Chou
J. Cancer 2016; 7(13): 1833-1841. doi:10.7150/jca.15692
[Abstract] [Full text] [PDF]

Research Paper
Potential Function of Exogenous Vimentin on the Activation of Wnt Signaling Pathway in Cancer Cells
Arun Satelli, Jiemiao Hu, Xueqing Xia, Shulin Li
J. Cancer 2016; 7(13): 1824-1832. doi:10.7150/jca.15622
[Abstract] [Full text] [PDF]

Research Paper
Interleukin-6 from Ovarian Mesenchymal Stem Cells Promotes Proliferation, Sphere and Colony Formation and Tumorigenesis of an Ovarian Cancer Cell Line SKOV3
Dah-Ching Ding, Hwan-Wun Liu, Tang-Yuan Chu
J. Cancer 2016; 7(13): 1815-1823. doi:10.7150/jca.16116
[Abstract] [Full text] [PDF]

Short Research Communication
Total PC Activity Is Increased in Uterine Lavage of Post-Menopausal Endometrial but Not Ovarian Cancer Patients
Sophea Heng, Andrew N. Stephens, Tom W. Jobling, Guiying Nie
J. Cancer 2016; 7(13): 1812-1814. doi:10.7150/jca.16331
[Abstract] [Full text] [PDF]

Research Paper
Transketolase Serves a Poor Prognosticator in Esophageal Cancer by Promoting Cell Invasion via Epithelial-Mesenchymal Transition
Yin-Kai Chao, Ta-Lun Peng, Wen-Yu Chuang, Chi-Ju Yeh, Yan-Liang Li, Ya-Ching Lu, Ann-Joy Cheng
J. Cancer 2016; 7(13): 1804-1811. doi:10.7150/jca.15467
[Abstract] [Full text] [PDF]

Research Paper
Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma
Ao Huang, Xin Zhang, Shao-Lai Zhou, Ya Cao, Xiao-Wu Huang, Jia Fan, Xin-Rong Yang, Jian Zhou
J. Cancer 2016; 7(13): 1798-1803. doi:10.7150/jca.15618
[Abstract] [Full text] [PDF]

Short Research Communication
Noninvasive Monitoring of Glioma Growth in the Mouse
Francesco Alessandrini, Davide Ceresa, Irene Appolloni, Daniela Marubbi, Paolo Malatesta
J. Cancer 2016; 7(13): 1791-1797. doi:10.7150/jca.15564
[Abstract] [Full text] [PDF]

Research Paper
Diet- and Genetically-induced Obesity Produces Alterations in the Microbiome, Inflammation and Wnt Pathway in the Intestine of Apc+/1638N Mice: Comparisons and Contrasts
Wei Liu, Jimmy W. Crott, Lin Lyu, Anna C. Pfalzer, Jinchao Li, Sang-Woon Choi, Yingke Yang, Joel B. Mason, Zhenhua Liu
J. Cancer 2016; 7(13): 1780-1790. doi:10.7150/jca.15792
[Abstract] [Full text] [PDF]

Research Paper
Preoperative Lymphocyte-Monocyte Ratio Is a Predictor of Suboptimal Cytoreduction in Stage III-IV Epithelial Ovarian Cancer
Wankyu Eo, Hong-Bae Kim, Yong Joo Lee, Dong Soo Suh, Ki Hyung Kim, Heungyeol Kim
J. Cancer 2016; 7(13): 1772-1779. doi:10.7150/jca.15724
[Abstract] [Full text] [PDF]

Research Paper
Molecular Characterization and Enhancement of Anticancer Activity of Caffeic Acid Phenethyl Ester by γ Cyclodextrin
Renu Wadhwa, Nupur Nigam, Priyanshu Bhargava, Jaspreet Kaur Dhanjal, Sukriti Goyal, Abhinav Grover, Durai Sundar, Yoshiyuki Ishida, Keiji Terao, Sunil C Kaul
J. Cancer 2016; 7(13): 1755-1771. doi:10.7150/jca.15170
[Abstract] [Full text] [PDF]

Research Paper
Pretreatment TG/HDL-C Ratio Is Superior to Triacylglycerol Level as an Independent Prognostic Factor for the Survival of Triple Negative Breast Cancer Patients
Danian Dai, Bo Chen, Bin Wang, Hailin Tang, Xing Li, Zhiping Zhao, Xuan Li, Xiaoming Xie, Weidong Wei
J. Cancer 2016; 7(12): 1747-1754. doi:10.7150/jca.15776
[Abstract] [Full text] [PDF]

Research Paper
MiR-193a-5p Targets the Coding Region of AP-2α mRNA and Induces Cisplatin Resistance in Bladder Cancers
Ji Zhou, Huaxin Duan, Yu Xie, Yichong Ning, Xing Zhang, Na Hui, Chunqing Wang, Jian Zhang, Jianlin Zhou
J. Cancer 2016; 7(12): 1740-1746. doi:10.7150/jca.15620
[Abstract] [Full text] [PDF]

Research Paper
XPG Gene Polymorphisms Contribute to Colorectal Cancer Susceptibility: A Two-Stage Case-Control Study
Rui-Xi Hua, Zhen-Jian Zhuo, Jinhong Zhu, Shao-Dan Zhang, Wen-Qiong Xue, Jiang-Bo Zhang, Hong-Mei Xu, Xi-Zhao Li, Pei-Fen Zhang, Jing He, Wei-Hua Jia
J. Cancer 2016; 7(12): 1731-1739. doi:10.7150/jca.15602
[Abstract] [Full text] [PDF]

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