Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Research Paper
Profiling chemotherapy-associated myelotoxicity among Chinese gastric cancer population receiving cytotoxic conventional regimens: epidemiological features, timing, predictors and clinical impacts
Ci Zhu, Yan Wang, Xicheng Wang, Chunmei Bai, Dan Su, Bing Cao, Jianming Xu
J. Cancer 2017; 8(13): 2614-2625. doi:10.7150/jca.17847
[Abstract] [Full text] [PDF]

Research Paper
Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy
Amir Hassan Navaei, Beatriz A Walter, Vanessa Moreno, Svetlana D Pack, Peter Pinto, Maria J Merino
J. Cancer 2017; 8(13): 2604-2613. doi:10.7150/jca.16751
[Abstract] [Full text] [PDF]

Research Paper
Pretreatment Nomograms for Local and Regional Recurrence after Radical Radiation Therapy for Primary Nasopharyngeal Carcinoma
Fo-ping Chen, Li Lin, Zhen-yu Qi, Guan-qun Zhou, Rui Guo, Jiang Hu, Ai-Hua Lin, Jun Ma, Ying Sun
J. Cancer 2017; 8(13): 2595-2603. doi:10.7150/jca.20255
[Abstract] [Full text] [PDF]

Research Paper
Decreased Overall and Cancer-Specific Mortality with Neoadjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma Treated by Intensity-modulated Radiotherapy: Multivariate Competing Risk Analysis
Jian Zhang, Hao Peng, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun, Jun Ma
J. Cancer 2017; 8(13): 2587-2594. doi:10.7150/jca.20081
[Abstract] [Full text] [PDF]

Research Paper
Differentially Expressed lncRNAs in Gastric Cancer Patients: A Potential Biomarker for Gastric Cancer Prognosis
Xianglong Tian, Xiaoqiang Zhu, Tingting Yan, Chenyang Yu, Chaoqin Shen, Jie Hong, Haoyan Chen, Jing-Yuan Fang
J. Cancer 2017; 8(13): 2575-2586. doi:10.7150/jca.19980
[Abstract] [Full text] [PDF]

Research Paper
LHX6, An Independent Prognostic Factor, Inhibits Lung Adenocarcinoma Progression through Transcriptional Silencing of β-catenin
Juntang Yang, Fei Han, Wenbin Liu, Mingqian Zhang, Yongsheng Huang, Xianglin Hao, Xiao Jiang, Li Yin, Hongqiang Chen, Jia Cao, Huidong Zhang, Jinyi Liu
J. Cancer 2017; 8(13): 2561-2574. doi:10.7150/jca.19972
[Abstract] [Full text] [PDF]

Research Paper
A Multi-Center Prospective Study to Validate an Algorithm Using Urine and Plasma Biomarkers for Predicting Gleason ≥3+4 Prostate Cancer on Biopsy
Maher Albitar, Wanlong Ma, Lars Lund, Babak Shahbaba, Edward Uchio, Soren Feddersen, Donald Moylan, Kirk Wojno, Neal Shore
J. Cancer 2017; 8(13): 2554-2560. doi:10.7150/jca.20031
[Abstract] [Full text] [PDF]

Research Paper
Identification of Novel Epitopes with Agonistic Activity for the Development of Tumor Immunotherapy Targeting TRAIL-R1
Lu Guo, Xin Sun, Zhichao Hao, Jingjing Huang, Xiaojian Han, Yajie You, Yaying Li, Meiying Shen, Tatsuhiko Ozawa, Hiroyuki Kishi, Atsushi Muraguchi, Aishun Jin
J. Cancer 2017; 8(13): 2542-2553. doi:10.7150/jca.19918
[Abstract] [Full text] [PDF]

Research Paper
The Clinical Effect of Metformin on the Survival of Lung Cancer Patients with Diabetes: A Comprehensive Systematic Review and Meta-analysis of Retrospective Studies
Xun Cao, Zhe-Sheng Wen, Xu-Dong Wang, Yong Li, Kui-Yuan Liu, Xin Wang
J. Cancer 2017; 8(13): 2532-2541. doi:10.7150/jca.19750
[Abstract] [Full text] [PDF]

Research Paper
Wnt3a Expression Is Associated with Epithelial-Mesenchymal Transition and Impacts Prognosis of Lung Adenocarcinoma Patients
Jinming Xu, Wang Lv, Yeji Hu, Luming Wang, Yiqing Wang, Jinlin Cao, Jian Hu
J. Cancer 2017; 8(13): 2523-2531. doi:10.7150/jca.18560
[Abstract] [Full text] [PDF]

Research Paper
Rac3 Regulates Cell Invasion, Migration and EMT in Lung Adenocarcinoma through p38 MAPK Pathway
Chenlei Zhang, Tieqin Liu, Gebang Wang, Huan Wang, Xiaofang Che, Xinghua Gao, Hongxu Liu
J. Cancer 2017; 8(13): 2511-2522. doi:10.7150/jca.18161
[Abstract] [Full text] [PDF]

Research Paper
miR-618 Inhibits Prostate Cancer Migration and Invasion by Targeting FOXP2
Xian-Lu Song, Yao Tang, Xiang-Hui Lei, Shan-Chao Zhao, Zi-Qing Wu
J. Cancer 2017; 8(13): 2501-2510. doi:10.7150/jca.17407
[Abstract] [Full text] [PDF]

Review
Chromosomal and Genomic Variations in Esophageal Squamous Cell Carcinoma: A Review of Technologies, Applications, and Prospections
Qi Song, Dongxian Jiang, Haixing Wang, Jie Huang, Yalan Liu, Chen Xu, Yingyong Hou
J. Cancer 2017; 8(13): 2492-2500. doi:10.7150/jca.19601
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of Serum miR-10b Is Associated with Poor Prognosis in Patients with Melanoma
Ming Bai, Hailin Zhang, Loubin Si, Nanze Yu, Ang Zeng, Ru Zhao
J. Cancer 2017; 8(13): 2487-2491. doi:10.7150/jca.18824
[Abstract] [Full text] [PDF]

Research Paper
Uncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth
Yoshikazu Hayashi, Tomoyo Kawakubo-Yasukochi, Akiko Mizokami, Mai Hazekawa, Tomiko Yakura, Munekazu Naito, Hiroshi Takeuchi, Seiji Nakamura, Masato Hirata
J. Cancer 2017; 8(13): 2478-2486. doi:10.7150/jca.18648
[Abstract] [Full text] [PDF]

Research Paper
Chemokine Receptors CXCR4 and CXCR7 are Associated with Tumor Aggressiveness and Prognosis in Extramammary Paget Disease
Kun Chang, Gao-Xiang Li, Yun-Yi Kong, Xu-Xia Shen, Yuan-Yuan Qu, Zhong-Wei Jia, Yue Wang, Bo Dai, Ding-Wei Ye
J. Cancer 2017; 8(13): 2471-2477. doi:10.7150/jca.19127
[Abstract] [Full text] [PDF]

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