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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma
Ma Xiao-Long, Zhu Kun-Peng, Zhang Chun-Lin
J. Cancer 2018; 9(10): 1856-1862. doi:10.7150/jca.24619
[Abstract] [Full text] [PDF]

Research Paper
Antagonistic role of GSK3 isoforms in glioma survival
Vidhi Vashishtha, Nupur Jinghan, Ajay K.Yadav
J. Cancer 2018; 9(10): 1846-1855. doi:10.7150/jca.21248
[Abstract] [Full text] [PDF]

Research Paper
Prognostic value of MET copy number gain in non-small-cell lung cancer: an updated meta-analysis
Jung Han Kim, Hyeong Su Kim, Bum Jun Kim
J. Cancer 2018; 9(10): 1836-1845. doi:10.7150/jca.24980
[Abstract] [Full text] [PDF]

Research Paper
P21-activated kinase 7 (PAK7) interacts with and activates Wnt/β-catenin signaling pathway in breast cancer
Kai Li, Xiaolong Xu, Yanqi He, Yihao Tian, Wenting Pan, Liu Xu, Yanbin Ma, Yang Gao, Jingbo Gao, Yuwen Qi, Lei Wei, Jingwei Zhang
J. Cancer 2018; 9(10): 1821-1835. doi:10.7150/jca.24934
[Abstract] [Full text] [PDF]

Research Paper
Tumor PD-L1 Expression and Clinical Outcomes in Advanced-stage Non-Small Cell Lung Cancer Patients Treated with Nivolumab or Pembrolizumab: Real-World Data in Taiwan
Shu-Yung Lin, Ching-Yao Yang, Bin-Chi Liao, Chao-Chi Ho, Wei-Yu Liao, Kuan-Yu Chen, Tzu-Hsiu Tsai, Chia-Lin Hsu, Wei-Hsun Hsu, Kang-Yi Su, Yih-Leong Chang, Jih-Hsiang Lee, Chia-Chi Lin, Jin-Yuan Shih, James Chih-Hsin Yang, Chong-Jen Yu
J. Cancer 2018; 9(10): 1813-1820. doi:10.7150/jca.24985
[Abstract] [Full text] [PDF]

Research Paper
Differential diagnostic roles of the serum CA19-9, total bilirubin (TBIL) and the ratio of CA19-9 to TBIL for benign and malignant
Wei Liu, Qiaofei Liu, Wenqin Wang, Penghui Wang, Jieming Chen, Tao Hong, Ning Zhang, Binglu Li, Qiang Qu, Xiaodong He
J. Cancer 2018; 9(10): 1804-1812. doi:10.7150/jca.25093
[Abstract] [Full text] [PDF]

Research Paper
Trends in Treatment for Prostate Cancer in China: Preliminary Patterns of Care Study in a Single Institution
Feng Zhao, Jiayan Shen, Zuguo Yuan, Xiaokai Yu, Peng Jiang, Baishu Zhong, Jianjian Xiang, Guoping Ren, Liping Xie, Senxiang Yan
J. Cancer 2018; 9(10): 1797-1803. doi:10.7150/jca.25113
[Abstract] [Full text] [PDF]

Research Paper
The impact of microsatellite instability status and sidedness of the primary tumor on the effect of bevacizumab-containing chemotherapy in patients with metastatic colorectal cancer
Seung Tae Kim, Hee Kyung Kim, Jeeyun Lee, Se Hoon Park, Ho Yeong Lim, Young Suk Park, Won Ki Kang, Joon Oh Park
J. Cancer 2018; 9(10): 1791-1796. doi:10.7150/jca.25132
[Abstract] [Full text] [PDF]

Research Paper
Oncoplastic breast reconstruction with omental flap: A retrospective study and systematic review
Chao Ni, Ziguan Zhu, Yin Xin, Qingping Xie, Hongjun Yuan, Miaochun Zhong, Wenjie Xia, Xiaoyan Zhu, Zhengye Lv, Xiangyang Song
J. Cancer 2018; 9(10): 1782-1790. doi:10.7150/jca.25556
[Abstract] [Full text] [PDF]

Review
Current status and future directions of cancer immunotherapy
Hongming Zhang, Jibei Chen
J. Cancer 2018; 9(10): 1773-1781. doi:10.7150/jca.24577
[Abstract] [Full text] [PDF]

Research Paper
The prognosis of neck residue nasopharyngeal carcinoma (NPC) patients: results from a case-cohort study
Sai-Lan Liu, Lin-Quan Tang, Qiu-Yan Chen, Huan-Xin Lin, Qi Yang, Qian Zhu, Wen Wen, Shan-Shan Guo, Li-Ting Liu, Yang Li, Hao-Jun Xie, Qing-Nan Tang, Xue-Song Sun, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Chao Lin, Xiao-Wen Lan, Hai-Qiang Mai, Ling Guo
J. Cancer 2018; 9(10): 1765-1772. doi:10.7150/jca.24573
[Abstract] [Full text] [PDF]

Research Paper
Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer
Jingwei Liu, Hao Li, Shixuan Shen, Liping Sun, Yuan Yuan, Chengzhong Xing
J. Cancer 2018; 9(10): 1754-1764. doi:10.7150/jca.24569
[Abstract] [Full text] [PDF]

Research Paper
Sorafenib Monotherapy Versus Sorafenib Combined with Regional Therapies for Hepatocellular Carcinoma Patients with Pulmonary Oligometastases: A Propensity Score-matched Analysis
Jinbin Chen, Shixun Lu, Yaojun Zhang, Li Xu, Jiancong Chen, Juncheng Wang, Minshan Chen, Rongxin Zhang, Zhongguo Zhou
J. Cancer 2018; 9(10): 1745-1753. doi:10.7150/jca.24568
[Abstract] [Full text] [PDF]

Research Paper
A predicting model of bone marrow malignant infiltration in 18F-FDG PET/CT images with increased diffuse bone marrow FDG uptake
Mingge Zhou, Yumei Chen, Jianjun Liu, Gang Huang
J. Cancer 2018; 9(10): 1737-1744. doi:10.7150/jca.24836
[Abstract] [Full text] [PDF]

Research Paper
Monitoring changes in quality of life in patients with lung cancer under treatment with chemotherapy and co administration of zoledronic acid by using specialized questionnaires
Ioannis Tremmas, George Petsatodis, Michael Potoupnis, Stella Laskou, Dimitrios Giannakidis, Stylianos Mantalovas, Charilaos Koulouris, Athanasios Katsaounis, Efstathios Pavlidis, Aikaterini Amaniti, Haidong Huang, Chong Bai, Dongchen Shi, Athanasios Dardas, Paul Zarogoulidis, Chrisanthi Sardeli, Fotis Konstantinou, Nikolaos Katsikogiannis, Konstantinos Zarogoulidis, Ilias Karapantzos, Chrysanthi Karapantzou, Xiaping Shen, Isaak Kesisoglou, Konstantinos Sapalidis
J. Cancer 2018; 9(10): 1731-1736. doi:10.7150/jca.24785
[Abstract] [Full text] [PDF]

Research Paper
The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: Analyses of pooled data from two phase II randomized clinical trials (HANGESHA-G and HANGESHA-C)
Kazuhiro Nishikawa, Toru Aoyama, Mari S Oba, Takaki Yoshikawa, Chu Matsuda, Yoshinori Munemoto, Nobuhiro Takiguchi, Kazuaki Tanabe, Naoki Nagata, Motohiro Imano, Mitsuru Oshiro, Ryoji Fukushima, Masato Kataoka, Satoshi Morita, Akira Tsuburaya, Hideyuki Mishima, Toru Kono, Junichi Sakamoto
J. Cancer 2018; 9(10): 1725-1730. doi:10.7150/jca.24733
[Abstract] [Full text] [PDF]

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