Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
new Oncomedicine now accepts submissions.
  • new Impact factor is 3.609 according to the 2016 release of Journal Citation Reports. Congratulations!
  • Indexed in SCI Expanded, PubMed and full texts in PubMed Central, Europe PubMed Central, and PMC Canada.
  • High visibility of articles over the Internet.

Cover suggestion ...details

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
Cover image

Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
MicroRNA Expression Profile on Solid Subtype of Invasive Lung Adenocarcinoma Reveals a Panel of Four miRNAs to Be Associated with Poor Prognosis in Chinese Patients
Yong-Qiang Zhang, Wei-Ya Wang, Jian-Xin Xue, Yan Xu, Ping Fan, Bennett Adam Caughey, Wei-Wei Tan, Gui-Qun Cao, Li-Li Jiang, You Lu, Kang Zhang, Xun Hu
J. Cancer 2016; 7(12): 1610-1620. doi:10.7150/jca.14923
[Abstract] [Full text] [PDF]

Short Research Communication
Differential Roles of Carboxylated and Uncarboxylated Osteocalcin in Prostate Cancer Growth
Yoshikazu Hayashi, Tomoyo Kawakubo-Yasukochi, Akiko Mizokami, Hiroshi Takeuchi, Seiji Nakamura, Masato Hirata
J. Cancer 2016; 7(12): 1605-1609. doi:10.7150/jca.15523
[Abstract] [Full text] [PDF]

Review
Current Status and Perspective of Immunotherapy in Gastrointestinal Cancers
Jung Hoon Kim, Bum Jun Kim, Hyeong Su Kim, Jung Han Kim
J. Cancer 2016; 7(12): 1599-1604. doi:10.7150/jca.16208
[Abstract] [Full text] [PDF]

Research Paper
African American Race is an Independent Risk Factor in Survival from Initially Diagnosed Localized Breast Cancer
Robert Wieder, Basit Shafiq, Nabil Adam
J. Cancer 2016; 7(12): 1587-1598. doi:10.7150/jca.16012
[Abstract] [Full text] [PDF]

Research Paper
AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells
Sherif Abdelhamed, Keisuke Ogura, Satoru Yokoyama, Ikuo Saiki, Yoshihiro Hayakawa
J. Cancer 2016; 7(12): 1579-1586. doi:10.7150/jca.14713
[Abstract] [Full text] [PDF]

Review
Effects of Animal Venoms and Toxins on Hallmarks of Cancer
Janeyuth Chaisakul, Wayne C. Hodgson, Sanjaya Kuruppu, Naiyarat Prasongsook
J. Cancer 2016; 7(11): 1571-1578. doi:10.7150/jca.15309
[Abstract] [Full text] [PDF]

Review
Hepatocellular Carcinoma and Diffusion-Weighted MRI: Detection and Evaluation of Treatment Response
Jill S Gluskin, Fabrizio Chegai, Serena Monti, Ettore Squillaci, Lorenzo Mannelli
J. Cancer 2016; 7(11): 1565-1570. doi:10.7150/jca.14582
[Abstract] [Full text] [PDF]

Research Paper
Bleomycin (BLM) Induces Epithelial-to-Mesenchymal Transition in Cultured A549 Cells via the TGF-β/Smad Signaling Pathway
Kui-Jun Chen, Qing Li, Cang-mei Wen, Zhao-Xia Duan, Jie yuan Zhang, Chuan Xu, Jian-Min Wang
J. Cancer 2016; 7(11): 1557-1564. doi:10.7150/jca.15566
[Abstract] [Full text] [PDF]

Research Paper
Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis
Chan Kim, Hannah Yang, Intae Park, Hong Jae Chon, Joo Hoon Kim, Woo Sun Kwon, Won Suk Lee, Tae Soo Kim, Sun Young Rha
J. Cancer 2016; 7(11): 1550-1556. doi:10.7150/jca.15578
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Impact of Thrombospodin-2 (THBS2) Overexpression on Patients with Urothelial Carcinomas of Upper Urinary Tracts and Bladders
I-Wei Chang, Chien-Feng Li, Victor Chia-Hsiang Lin, Hong-Lin He, Per-In Liang, Wen-Jeng Wu, Ching-Chia Li, Chun-Nung Huang
J. Cancer 2016; 7(11): 1541-1549. doi:10.7150/jca.15696
[Abstract] [Full text] [PDF]

Research Paper
SOX4 Promotes Progression in OLP-Associated Squamous Cell Carcinoma
Yi Liu, Li Cui, Junwei Huang, Eoon Hye Ji, Wei Chen, Diana Messadi, Shen Hu
J. Cancer 2016; 7(11): 1534-1540. doi:10.7150/jca.15689
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of Regulatory Volume Decrease Enhances the Cytocidal Effect of Hypotonic Shock in Hepatocellular Carcinoma
Michihiro Kudou, Atsushi Shiozaki, Toshiyuki Kosuga, Daisuke Ichikawa, Hirotaka Konishi, Ryo Morimura, Shuhei Komatsu, Hisashi Ikoma, Hitoshi Fujiwara, Kazuma Okamoto, Shigekuni Hosogi, Takashi Nakahari, Yoshinori Marunaka, Eigo Otsuji
J. Cancer 2016; 7(11): 1524-1533. doi:10.7150/jca.15181
[Abstract] [Full text] [PDF]

Research Paper
Cytotoxic Chemotherapy as First-Line Therapy for Advanced Non-Small-Cell Lung Cancer in Taiwan: Daily Practice
Yi-Hsin Liang, Yu-Yun Shao, Bin-Chi Liao, Ho-Sheng Lee, James Chih-Hsin Yang, Ho-Min Chen, Chun-Ju Chiang, Ann-Lii Cheng, Mei-Shu Lai
J. Cancer 2016; 7(11): 1515-1523. doi:10.7150/jca.15180
[Abstract] [Full text] [PDF]

Review
Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment
Kishore Polireddy, Qi Chen
J. Cancer 2016; 7(11): 1497-1514. doi:10.7150/jca.14922
[Abstract] [Full text] [PDF]

Research Paper
Magnetofection Based on Superparamagnetic Iron Oxide Nanoparticles Weakens Glioma Stem Cell Proliferation and Invasion by Mediating High Expression of MicroRNA-374a
Zhiguang Pan, Zhifeng Shi, Hua Wei, Fengyan Sun, Jianping Song, Yongyi Huang, Te Liu, Ying Mao
J. Cancer 2016; 7(11): 1487-1496. doi:10.7150/jca.15515
[Abstract] [Full text] [PDF]

Research Paper
Narrowing Resection of Parametrial Tissues Is Feasible in Low-Risk Cases of Stage IA2-IB1 Cervical Cancer
Xue-Lian Li, Xiao-Xia Liu, Guan-Shu Cao, Dan-Dan Ju, Hua Jiang
J. Cancer 2016; 7(11): 1481-1486. doi:10.7150/jca.15466
[Abstract] [Full text] [PDF]

More ...