Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Evaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers
Hankui Chen, Helu Liu, Hanqing Zou, Rui Chen, Yuhong Dou, Shile Sheng, Shengming Dai, Junmei Ai, Joshua Melson, Rick A. Kittles, Mehdi Pirooznia, Michael J. Liptay, Jeffrey A. Borgia, Youping Deng
J. Cancer 2016; 7(5): 490-499. doi:10.7150/jca.12351
[Abstract] [Full text] [PDF]

Research Paper
The Impact of PD-L1 Expression in Patients with Metastatic GEP-NETs
Seung Tae Kim, Sang Yun Ha, Sujin Lee, Soomin Ahn, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Kyoung-Mee Kim, Young Suk Park
J. Cancer 2016; 7(5): 484-489. doi:10.7150/jca.13711
[Abstract] [Full text] [PDF]

Research Paper
Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer
Yaping Zhang, Chengyan He, Ling Qiu, Yanmin Wang, Xuzhen Qin, Yujie Liu, Zhili Li
J. Cancer 2016; 7(4): 477-483. doi:10.7150/jca.13870
[Abstract] [Full text] [PDF]

Research Paper
SPOCK1 Overexpression Confers a Poor Prognosis in Urothelial Carcinoma
Li-Jung Ma, Wen-Jen Wu, Yu-Hui Wang, Ting-Feng Wu, Peir-In Liang, I-Wei Chang, Hong-Lin He, Chien-Feng Li
J. Cancer 2016; 7(4): 467-476. doi:10.7150/jca.13625
[Abstract] [Full text] [PDF]

Research Paper
Newcastle Disease Virus Hemagglutinin Neuraminidase as a Potential Cancer Targeting Agent
Ali Baradaran, Khatijah Yusoff, Norazizah Shafee, Raha Abdul Rahim
J. Cancer 2016; 7(4): 462-466. doi:10.7150/jca.13566
[Abstract] [Full text] [PDF]

Research Paper
The Traditional Chinese Medicine Baicalein Potently Inhibits Gastric Cancer Cells
Jiasheng Mu, Tianrun Liu, Lin Jiang, Xiangsong Wu, Yang Cao, Maolan Li, Qian Dong, Yingbin Liu, Haineng Xu
J. Cancer 2016; 7(4): 453-461. doi:10.7150/jca.13548
[Abstract] [Full text] [PDF]

Research Paper
PCDH8 is Frequently Inactivated by Promoter Hypermethylation in Liver Cancer: Diagnostic and Clinical Significance
Cheng Zhang, Yunfei Peng, Fan Yang, Ruixi Qin, Wenjun Liu, Cuijuan Zhang
J. Cancer 2016; 7(4): 446-452. doi:10.7150/jca.13065
[Abstract] [Full text] [PDF]

Review
Learning about the Importance of Mutation Prevention from Curable Cancers and Benign Tumors
Gangshi Wang, Lichan Chen, Baofa Yu, Lucas Zellmer, Ningzhi Xu, D. Joshua Liao
J. Cancer 2016; 7(4): 436-445. doi:10.7150/jca.13832
[Abstract] [Full text] [PDF]

Research Paper
Chromobox Homolog 4 is Positively Correlated to Tumor Growth, Survival and Activation of HIF-1α Signaling in Human Osteosarcoma under Normoxic Condition
Jielai Yang, Dongdong Cheng, Bin Zhu, Shumin Zhou, Tao Ying, Qingcheng Yang
J. Cancer 2016; 7(4): 427-435. doi:10.7150/jca.13749
[Abstract] [Full text] [PDF]

Research Paper
E3 Ubiquitin Ligase Siah-1 is Down-regulated and Fails to Target Natural HBx Truncates for Degradation in Hepatocellular Carcinoma
Jing Zhao, Jing Wu, Hao Cai, Dan Wang, Long Yu, Wen-Hong Zhang
J. Cancer 2016; 7(4): 418-426. doi:10.7150/jca.13019
[Abstract] [Full text] [PDF]

Research Paper
Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells
Feng Wang, Ling Ma, Zhengkui Zhang, Xiaoran Liu, Hongqiao Gao, Yan Zhuang, Pei Yang, Marko Kornmann, Xiaodong Tian, Yinmo Yang
J. Cancer 2016; 7(4): 408-417. doi:10.7150/jca.13305
[Abstract] [Full text] [PDF]

Review
Calcitriol in Combination Therapy for Prostate Cancer: Pharmacokinetic and Pharmacodynamic Interactions
Mohamed Ben-Eltriki, Subrata Deb, Emma S. Tomlinson Guns
J. Cancer 2016; 7(4): 391-407. doi:10.7150/jca.13470
[Abstract] [Full text] [PDF]

Review
Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Georgia Pitsiou, Bernd Linsmeier, Drosos Tsavlis, Ioannis Kioumis, Eleni Papadaki, Lutz Freitag, Theodora Tsiouda, J Francis Turner, Robert Browning, Michael Simoff, Nikolaos Sachpekidis, Kosmas Tsakiridis, Bojan Zaric, Lonny Yarmus, Sofia Baka, Grigoris Stratakos, Harald Rittger
J. Cancer 2016; 7(4): 377-390. doi:10.7150/jca.13611
[Abstract] [Full text] [PDF]

Research Paper
HYOU1, Regulated by LPLUNC1, Is Up-Regulated in Nasopharyngeal Carcinoma and Associated with Poor Prognosis
Yujuan Zhou, Qianjin Liao, Xiayu Li, Hui Wang, Fang Wei, Jie Chen, Jing Yang, Zhaoyang Zeng, Xiaofang Guo, Pan Chen, Wenling Zhang, Ke Tang, Xiaoling Li, Wei Xiong, Guiyuan Li
J. Cancer 2016; 7(4): 367-376. doi:10.7150/jca.13695
[Abstract] [Full text] [PDF]

Short Research Communication
Kinetics of Circulating Plasma Cell-Free DNA in Paediatric Classical Hodgkin Lymphoma
Simona Primerano, Roberta Burnelli, Elisa Carraro, Marta Pillon, Caterina Elia, Piero Farruggia, Alessandra Sala, Luciana Vinti, Salvatore Buffardi, Giuseppe Basso, Maurizio Mascarin, Lara Mussolin
J. Cancer 2016; 7(4): 364-366. doi:10.7150/jca.13593
[Abstract] [Full text] [PDF]

Research Paper
Ellagic Acid and Resveratrol Prevent the Development of Cisplatin Resistance in the Epithelial Ovarian Cancer Cell Line A2780
Laura H. Engelke, Alexandra Hamacher, Peter Proksch, Matthias U. Kassack
J. Cancer 2016; 7(4): 353-363. doi:10.7150/jca.13754
[Abstract] [Full text] [PDF]

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