Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Overexpression of the PSAT1 Gene in Nasopharyngeal Carcinoma Is an Indicator of Poor Prognosis
Kuang-Ming Liao, Tung-Bo Chao, Yu-Feng Tian, Ching-Yih Lin, Sung-Wei Lee, Hua-Ying Chuang, Ti-Chun Chan, Tzu-Ju Chen, Chung-Hsi Hsing, Ming-Jen Sheu, Chien-Feng Li
J. Cancer 2016; 7(9): 1088-1094. doi:10.7150/jca.15258
[Abstract] [Full text] [PDF]

Review
Exosomes for Immunoregulation and Therapeutic Intervention in Cancer
Xuan Zhang, Zenglin Pei, Jinyun Chen, Chunxia Ji, Jianqing Xu, Xiaoyan Zhang, Jin Wang
J. Cancer 2016; 7(9): 1081-1087. doi:10.7150/jca.14866
[Abstract] [Full text] [PDF]

Review
TWIST1 and BMI1 in Cancer Metastasis and Chemoresistance
Hong Ren, Peizhun Du, Zongyu Ge, Yiting Jin, Di Ding, Xiuping Liu, Qiang Zou
J. Cancer 2016; 7(9): 1074-1080. doi:10.7150/jca.14031
[Abstract] [Full text] [PDF]

Research Paper
A Retrospective Comparison of Taxane and Fluorouracil-based Chemoradiotherapy in Patients with Inoperable Esophageal Squamous Cell Carcinoma
Xiaojiang Sun, Shuiyun Han, Feiying Gu, Gang Lin, Zhun Wang, Yuezhen Wang, Yaping Xu
J. Cancer 2016; 7(9): 1066-1073. doi:10.7150/jca.13547
[Abstract] [Full text] [PDF]

Research Paper
MiR-34a and miR-203 Inhibit Survivin Expression to Control Cell Proliferation and Survival in Human Osteosarcoma Cells
Xun Chen, Xiao-Gang Chen, Xiaojing Hu, Tao Song, Xuehai Ou, Caiguo Zhang, Wentao Zhang, Chun Zhang
J. Cancer 2016; 7(9): 1057-1065. doi:10.7150/jca.15061
[Abstract] [Full text] [PDF]

Research Paper
Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer
Yu-Qin Sun, Jian-Wei Xie, Peng-Chen Chen, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Yao Lin, Chang-Ming Huang
J. Cancer 2016; 7(9): 1049-1056. doi:10.7150/jca.14778
[Abstract] [Full text] [PDF]

Research Paper
Genomic Profiling of Metastatic Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET) Patients in the Personalized-Medicine Era
Seung Tae Kim, Su Jin Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Jeeyun Lee, Young Suk Park
J. Cancer 2016; 7(9): 1044-1048. doi:10.7150/jca.14815
[Abstract] [Full text] [PDF]

Research Paper
Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China's Largest CAP Certified Laboratory
Zhengyu Zeng, Huaitao Yang, Zaibo Li, Xuekui He, Christopher C. Griffith, Xiamen Chen, Xiaolei Guo, Baowen Zheng, Shangwei Wu, Chengquan Zhao
J. Cancer 2016; 7(9): 1037-1043. doi:10.7150/jca.14971
[Abstract] [Full text] [PDF]

Research Paper
Survival Benefits of Small Anatomical Resection of the Liver for Patients with Hepatocellular Carcinoma and Impaired Liver Function, Based on New-Era Imaging Studies
Masahiko Sakoda, Shinichi Ueno, Satoshi Iino, Kiyokazu Hiwatashi, Koji Minami, Yota Kawasaki, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Shoji Natsugoe
J. Cancer 2016; 7(9): 1029-1036. doi:10.7150/jca.15174
[Abstract] [Full text] [PDF]

Research Paper
DJ-1 Is Upregulated in Oral Squamous Cell Carcinoma and Promotes Oral Cancer Cell Proliferation and Invasion
Shuaimei Xu, Dandan Ma, Rui Zhuang, Wenjuan Sun, Ying Liu, Jun Wen, Li Cui
J. Cancer 2016; 7(8): 1020-1028. doi:10.7150/jca.14539
[Abstract] [Full text] [PDF]

Research Paper
An Investigation on a Novel Anti-tumor Fusion Peptide of FSH33-53-IIKK
Runlin Yang, Ping Liu, Donghui Pan, Pengjun zhang, Zhicheng Bai, Yuping Xu, Lizhen Wang, Junjie Yan, Yongjun Yan, Xingdang Liu, Min Yang
J. Cancer 2016; 7(8): 1010-1019. doi:10.7150/jca.14425
[Abstract] [Full text] [PDF]

Research Paper
Glypican-1 as a Biomarker for Prostate Cancer: Isolation and Characterization
Quach Truong, Irene O. Justiniano, Aline L. Nocon, Julie T. Soon, Sandra Wissmueller, Douglas H. Campbell, Bradley J. Walsh
J. Cancer 2016; 7(8): 1002-1009. doi:10.7150/jca.14645
[Abstract] [Full text] [PDF]

Research Paper
The Long Noncoding RNA MALAT-1 is A Novel Biomarker in Various Cancers: A Meta-analysis Based on the GEO Database and Literature
Yumin Wang, Dan Xue, Yuwei Li, Xuya Pan, Xueying Zhang, Biao Kuang, Ming Zhou, Xiaoling Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng, Tubao Yang
J. Cancer 2016; 7(8): 991-1001. doi:10.7150/jca.14663
[Abstract] [Full text] [PDF]

Research Paper
The Role of Prion Protein Expression in Predicting Gastric Cancer Prognosis
Zhaoqing Tang, Ji Ma, Wei Zhang, Changguo Gong, Jing He, Ying Wang, Guohua Yu, Chonggang Yuan, Xuefei Wang, Yihong Sun, Jiyan Ma, Fenglin Liu, Yulan Zhao
J. Cancer 2016; 7(8): 984-990. doi:10.7150/jca.14237
[Abstract] [Full text] [PDF]

Research Paper
ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis
Youhong Wang, Xuehua Xu, Miao Pan, Tian Jin
J. Cancer 2016; 7(8): 973-983. doi:10.7150/jca.15118
[Abstract] [Full text] [PDF]

Research Paper
Association between Perioperative Blood Transfusion and Oncologic Outcomes after Curative Surgery for Renal Cell Carcinoma
Yong Hyun Park, Yong-June Kim, Seok Ho Kang, Hyeon Hoe Kim, Seok-Soo Byun, Ji Youl Lee, Sung-Hoo Hong
J. Cancer 2016; 7(8): 965-972. doi:10.7150/jca.15073
[Abstract] [Full text] [PDF]

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