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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Comparison of Three Radiobiological Models in Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer
Jia-Yang Lu, Zhu Lin, Pei-Xian Lin, Bao-Tian Huang
J. Cancer 2019; 10(19): 4655-4661. doi:10.7150/jca.33001
[Abstract] [Full text] [PDF]

Research Paper
Correlation between Candidate Single Nucleotide Variants and Several Clinicopathological Risk Factors Related to Breast Cancer in Jordanian Women: A Genotype-Phenotype Study
Laith N. AL-Eitan, Doaa M. Rababa'h, Mansour A. Alghamdi, Rame H. Khasawneh
J. Cancer 2019; 10(19): 4647-4654. doi:10.7150/jca.33857
[Abstract] [Full text] [PDF]

Research Paper
Adverse Effect of Lymph Node Dissection in Metastatic Renal Cell Cancer Patients Treated with Cytoreductive Nephrectomy: A Contemporary Analysis of Survival
Dalong Cao, Yongqiang Huang, Chuankai Zhang, Junlong Wu, Leijun Yu, Hailiang Zhang, Guohai Shi, Dingwei Ye
J. Cancer 2019; 10(19): 4639-4646. doi:10.7150/jca.33923
[Abstract] [Full text] [PDF]

Research Paper
Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma
Diekuo Zhang, Guo Li, Xiyu Chen, Qiancheng Jing, Chao Liu, Shanhong Lu, Donghai Huang, Yunyun Wang, Pingqing Tan, Jie Chen, Xin Zhang, Yuanzheng Qiu, Yong Liu
J. Cancer 2019; 10(19): 4633-4638. doi:10.7150/jca.35009
[Abstract] [Full text] [PDF]

Research Paper
Patients with Gastric Polyps need Colonoscopy Screening at Younger Age: A Large Prospective Cross-Sectional Study in China
Shenghong Zhang, Danping Zheng, Zhiwei Yang, Liru Hong, Siew Chien Ng, Minrui Li, Shanshan Huang, Shengbing Wang, Li Li, Manying Li, Hongshi Zhang, Jinghua Lin, Bihui Zhong, Yi Cui, Minhu Chen
J. Cancer 2019; 10(19): 4623-4632. doi:10.7150/jca.32857
[Abstract] [Full text] [PDF]

Research Paper
Predictors of the Survival of Primary and Secondary Older Osteosarcoma Patients
Zhan Wang, Bo Wu, Yuanxi Zhou, Xin Huang, Weibo Pan, Meng Liu, Xiaobo Yan, Nong Lin, Zhaoming Ye
J. Cancer 2019; 10(19): 4614-4622. doi:10.7150/jca.32627
[Abstract] [Full text] [PDF]

Research Paper
Long non-coding RNA TUG1 mediates 5-fluorouracil resistance by acting as a ceRNA of miR-197-3p in colorectal cancer
Meng Wang, Hanqing Hu, Yuliuming Wang, Quanlong Huang, Rui Huang, Yinggang Chen, Tianyi Ma, Tianyu Qiao, Qian Zhang, Hongyu Wu, Qingmin Chen, Dong Han, Guiyu Wang, Xishan Wang
J. Cancer 2019; 10(19): 4603-4613. doi:10.7150/jca.32065
[Abstract] [Full text] [PDF]

Research Paper
The risk trajectory between preoperative fasting glucose and common digestive tract cancer-specific mortality in the FIESTA cohort involving 6865 Chinese patients
Dan Hu, Feng Peng, Xiandong Lin, Hejun Zhang, Yan Xia, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
J. Cancer 2019; 10(19): 4596-4602. doi:10.7150/jca.31184
[Abstract] [Full text] [PDF]

Research Paper
Searching HPV genome for methylation sites involved in molecular progression to cervical precancer
Christine Kottaridi, Danai Leventakou, Abraham Pouliakis, Vasileios Pergialiotis, George Chrelias, Eugenia Patsouri, Andriani Zacharatou, Eleni Panopoulou, Vasileia Damaskou, Vasileios Sioulas, Charalambos Chrelias, Sofia Kalantaridou, Ioannis G. Panayiotides
J. Cancer 2019; 10(19): 4588-4595. doi:10.7150/jca.30081
[Abstract] [Full text] [PDF]

Review
Cellular Interactions in the Tumor Microenvironment: The Role of Secretome
Bianca Rodrigues da Cunha, Célia Domingos, Ana Carolina Buzzo Stefanini, Tiago Henrique, Giovana Mussi Polachini, Pedro Castelo-Branco, Eloiza Helena Tajara
J. Cancer 2019; 10(19): 4574-4587. doi:10.7150/jca.21780
[Abstract] [Full text] [PDF]

Research Paper
A nomogram to predict prognosis of patients with unresected hepatocellular carcinoma undergoing radiotherapy: a population-based study
Li Zhang, Li Yan, Hao Niu, Jie Ma, Bao-Ying Yuan, Yu-Han Chen, Yuan Zhuang, Yong Hu, Zhao-Chong Zeng, Zuo-Lin Xiang
J. Cancer 2019; 10(19): 4564-4573. doi:10.7150/jca.30365
[Abstract] [Full text] [PDF]

Research Paper
Prognostic models based on postoperative circulating tumor cells can predict poor tumor recurrence-free survival in patients with stage II-III colorectal cancer
Dong Wang, Yingchi Yang, Lan Jin, Jin Wang, Xiaomu Zhao, Guocong Wu, Jinghui Zhang, Tiankuo Kou, Hongwei Yao, Zhongtao Zhang
J. Cancer 2019; 10(19): 4552-4563. doi:10.7150/jca.30512
[Abstract] [Full text] [PDF]

Research Paper
HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma
Bo-Wen Dai, Zhi-Min Yang, Ping Deng, Yan-Rong Chen, Zhi-Jing He, Xi Yang, Sheng Zhang, Han-Jiang Wu, Zhen-Hu Ren
J. Cancer 2019; 10(19): 4540-4551. doi:10.7150/jca.30645
[Abstract] [Full text] [PDF]

Research Paper
Mesenchymal Stem Cells Accelerate the Remodeling of Bladder VX2 Tumor Interstitial Microenvironment by TGFβ1-Smad Pathway
Qingya Yang, Jun Chen, Yaofeng Zhu, Zhishun Xu
J. Cancer 2019; 10(19): 4532-4539. doi:10.7150/jca.30788
[Abstract] [Full text] [PDF]

Research Paper
Elevated CD36 expression correlates with increased visceral adipose tissue and predicts poor prognosis in ccRCC patients
Wen-Hao Xu, Yuan-Yuan Qu, Jun Wang, Hong-Kai Wang, Fang-Ning Wan, Jian-Yuan Zhao, Hai-Liang Zhang, Ding-Wei Ye
J. Cancer 2019; 10(19): 4522-4531. doi:10.7150/jca.30989
[Abstract] [Full text] [PDF]

Research Paper
Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-κB pathway
Xin Li, Shu Guo, Xi-Kun Xiong, Bao-Ying Peng, Jun-Ming Huang, Mei-Fen Chen, Feng-Yan Wang, Jian-Ning Wang
J. Cancer 2019; 10(19): 4509-4521. doi:10.7150/jca.31045
[Abstract] [Full text] [PDF]

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