A note on plagiarism (please read before submission): There is a zero-tolerance policy towards plagiarism (including self-plagiarism) in this journal. Manuscripts are screened for plagiarism before, during, and after publication, and if found they will be rejected at any stage of processing. See ...
newLatest Impact Factor 3.249. Congratulations!
new Oncomedicine now accepts submissions.

Cover suggestion ...details

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
Cover image

Research Paper
Upregulated Expression of Long Non-Coding RNA, LINC00460, Suppresses Proliferation of Colorectal Cancer.
Xin Wang, Fong-Ming Mo, Hao Bo, Lei Xiao, Guan-Yang Chen, Peng-Wei Zeng, Yan-Ning Huang, Zhuo Lei, Wei-Jie Yuan, Zi-Hua Chen
J. Cancer 2018; 9(16): 2834-2843. doi:10.7150/jca.26046
[Abstract] [Full text] [PDF]

Research Paper
Phosphorylation of the Cytoskeletal Protein CAP1 Regulates Non-Small Cell Lung Cancer Survival and Proliferation by GSK3β
Shuanshuan Xie, Yang Liu, Xuan Li, Min Tan, Changhui Wang, Jeffrey Field, Guolei Zhou
J. Cancer 2018; 9(16): 2825-2833. doi:10.7150/jca.25993
[Abstract] [Full text] [PDF]

Research Paper
Diagnostic accuracy of frozen section analysis of borderline ovarian tumors: a meta-analysis with emphasis on misdiagnosis factors
Zhen Huang, Li Li, ChengCheng Li, Samuel Ngaujah, Shu Yao, Ran Chu, Lin Xie, XingSheng Yang, Xiangning Zhang, Peishu Liu, Jie Jiang, Youzhong Zhang, Baoxia Cui, Kun Song, Beihua Kong
J. Cancer 2018; 9(16): 2817-2824. doi:10.7150/jca.25883
[Abstract] [Full text] [PDF]

Research Paper
MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma
Ju-deng Zeng, Ning Zhang, Gui-jun Zhao, Li-xia Xu, Yang Yang, Xiao-yi Xu, Meng-ke Chen, Hui-yun Wang, Steven Xiao-feng Zheng, Xiao-xing Li
J. Cancer 2018; 9(16): 2807-2816. doi:10.7150/jca.25680
[Abstract] [Full text] [PDF]

Research Paper
Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China
Zhilian Wang, Zaibo Li, Jing Li, Chen Wang, Wenhao Wang, Min Hao, Chengquan Zhao
J. Cancer 2018; 9(16): 2802-2806. doi:10.7150/jca.25614
[Abstract] [Full text] [PDF]

Research Paper
Multiple Primary Malignant Tumors - A Clinical Analysis of 15,321 Patients with Malignancies at a Single Center in China
Chongya Zhai, Yulan Cai, Fang Lou, Zhen Liu, Jiansheng Xie, Xiaoyun Zhou, Zhanggui Wang, Yong Fang, Hongming Pan, Weidong Han
J. Cancer 2018; 9(16): 2795-2801. doi:10.7150/jca.25482
[Abstract] [Full text] [PDF]

Research Paper
Polymorphisms in ERCC2 and ERCC5 and Risk of Prostate Cancer: A Meta-Analysis and Systematic Review
Yi Liu, Yonghui Hu, Meng Zhang, Runze Jiang, Chaozhao Liang
J. Cancer 2018; 9(16): 2786-2794. doi:10.7150/jca.25356
[Abstract] [Full text] [PDF]

Research Paper
Resection versus Resection with Preoperative Transcatheter Arterial Chemoembolization for Resectable Hepatocellular Carcinoma Recurrence
Qiang Tao, Wei He, Binkui Li, Yun Zheng, Ruhai Zou, Jingxian Shen, Wenwu Liu, Yuanping Zhang, Yunfei Yuan
J. Cancer 2018; 9(16): 2778-2785. doi:10.7150/jca.25033
[Abstract] [Full text] [PDF]

Research Paper
The Efficacy and Safety of Apatinib Treatment for Patients with Unresectable or Relapsed Liver Cancer: a retrospective study
Liu Zhen, Chen Jiali, Fang Yong, Xufeng Han, Pan Hongming, Han Weidong
J. Cancer 2018; 9(16): 2773-2777. doi:10.7150/jca.26376
[Abstract] [Full text] [PDF]

Research Paper
Concurrent Chemoradiotherapy with Docetaxel, Cisplatin, and 5-fluorouracil Improves Survival of Patients with Advanced Esophageal Cancer Compared with Conventional Concurrent Chemoradiotherapy with Cisplatin and 5-fluorouracil
Yukihisa Tamaki, Yoko Hieda, Masanobu Nakajima, Kazuhiro Kitajima, Rika Yoshida, Takeshi Yoshizako, Atsushi Ue, Mutsumi Tokudo, Noriyuki Hirahara, Ichiro Moriyama, Hiroyuki Kato, Taisuke Inomata
J. Cancer 2018; 9(16): 2765-2772. doi:10.7150/jca.23456
[Abstract] [Full text] [PDF]

Research Paper
Involvement of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Repressor in Helicobacter Pylori-related Gastric Pathogenesis
Renfei Zhu, Cheng Gao, Liuhua Wang, Guoxin Zhang, Weiming Zhang, Zhihong Zhang, Lizong Shen, Shoulin Wang
J. Cancer 2018; 9(15): 2757-2764. doi:10.7150/jca.26083
[Abstract] [Full text] [PDF]

Research Paper
XPA gene polymorphisms and risk of neuroblastoma in Chinese children: a two-center case-control study
Jing Tao, Zhen-Jian Zhuo, Meng Su, Lizhao Yan, Jing He, Jiao Zhang
J. Cancer 2018; 9(15): 2751-2756. doi:10.7150/jca.25973
[Abstract] [Full text] [PDF]

Research Paper
Clinic-pathologic Features and Prognostic Analysis of Thyroid Cancer in the Older Adult: A SEER Based Study
Li-Ye Shi, Jiang Liu, Lu-Jiao Yu, Yi-Ming Lei, Sean X. Leng, Hai-Yan Zhang
J. Cancer 2018; 9(15): 2744-2750. doi:10.7150/jca.24625
[Abstract] [Full text] [PDF]

Erratum
Correction: Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform
Bálint Péterfia
J. Cancer 2018; 9(15): 2743. doi:10.7150/jca.27625
[Abstract] [Full text] [PDF]

Research Paper
TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway
Dejiao He, Xuan Sun, Hongxia Yang, Xiaoli Li, Dingping Yang
J. Cancer 2018; 9(15): 2734-2742. doi:10.7150/jca.26374
[Abstract] [Full text] [PDF]

Research Paper
Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture
Yi-Meng Duan, Ying Jin, Meng-Li Guo, Leng-Xin Duan, Jian-Gang Wang
J. Cancer 2018; 9(15): 2723-2733. doi:10.7150/jca.26339
[Abstract] [Full text] [PDF]

More ...