Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Human Stromal Cells in the Peripheral Zone of the Prostate Promote Tumorigenesis of Prostatic Cancer Stem Cells through Up-regulation of C-Kit Expression
Yubing Peng, Qi Chen, Meng Gu, Yanbo Chen, Ming Zhang, Juan Zhou, Hao Wang, Yan Gao, Wenji Li, Zhong Wang, Zhikang Cai
J. Cancer 2015; 6(8): 776-785. doi:10.7150/jca.9961
[Abstract] [Full text] [PDF]

Research Paper
Deregulation of RGS17 Expression Promotes Breast Cancer Progression
Yuhua Li, Liliang Li, Junyi Lin, Xin Hu, Beixu Li, Aimin Xue, Yiwen Shen, Jieqing Jiang, Mingchang Zhang, Jianhui Xie, Ziqin Zhao
J. Cancer 2015; 6(8): 767-775. doi:10.7150/jca.11833
[Abstract] [Full text] [PDF]

Research Paper
Correcting the Shrinkage Effects of Formalin Fixation and Tissue Processing for Renal Tumors: toward Standardization of Pathological Reporting of Tumor Size
Thu Tran, Chandru P. Sundaram, Clinton D. Bahler, John N. Eble, David J. Grignon, M. Francesca Monn, Novae B. Simper, Liang Cheng
J. Cancer 2015; 6(8): 759-766. doi:10.7150/jca.12094
[Abstract] [Full text] [PDF]

Research Paper
Adjuvant Chemotherapy Correlates with Improved Survival after Radical Cystectomy in Patients with pT3b (Macroscopic Perivesical Tissue Invasion) Bladder Cancer
Hyung Suk Kim, Songzhe Piao, Kyung Chul Moon, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
J. Cancer 2015; 6(8): 750-758. doi:10.7150/jca.12259
[Abstract] [Full text] [PDF]

Research Paper
Methylation Profiling of Multiple Tumor Suppressor Genes in Hepatocellular Carcinoma and the Epigenetic Mechanism of 3OST2 Regulation
Haiyan Chen, Tingguo Zhang, Yan Sheng, Cheng Zhang, Yunfei Peng, Xiao Wang, Cuijuan Zhang
J. Cancer 2015; 6(8): 740-749. doi:10.7150/jca.11691
[Abstract] [Full text] [PDF]

Research Paper
Implications of Type1/2 Diabetes Mellitus in Breast Cancer Development: A General Female Population-based Cohort Study
Yung-Po Liaw, Pei-Chieh Ko, Shiou-Rung Jan, Jing-Yang Huang, Oswald Ndi Nfor, Chia-Chi Lung, Yi-Chen Chiang, Liang-Tsai Yeh, Ming-Chih Chou, Horng-Der Tsai, Yi-Hsuan Hsiao
J. Cancer 2015; 6(8): 734-739. doi:10.7150/jca.12197
[Abstract] [Full text] [PDF]

Research Paper
The Impact of Economic Recession on the Incidence and Treatment of Cancer
Kevin Y. Ennis, Ming-Hui Chen, Glenna C. Smith, Anthony V. D'Amico, Yuanye Zhang, S. Aidan Quinn, Shannon N. Ryemon, Daniel Goltz, Louis B. Harrison, Ronald D. Ennis
J. Cancer 2015; 6(8): 727-733. doi:10.7150/jca.11886
[Abstract] [Full text] [PDF]

Review
Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma
Linli Zhou, Kun Yang, Thomas Andl, R. Randall Wickett, Yuhang Zhang
J. Cancer 2015; 6(8): 717-726. doi:10.7150/jca.10865
[Abstract] [Full text] [PDF]

Research Paper
Association of IL10 -819C>T and -592C>A Polymorphisms with Non-Hodgkin Lymphoma Susceptibility: Evidence from Published Studies
Ting Zhang, Shang Xie, Jin-Hong Zhu, Qi-Wen Li, Jing He, Ai-Ping Zeng
J. Cancer 2015; 6(8): 709-716. doi:10.7150/jca.11745
[Abstract] [Full text] [PDF]

Research Paper
Anticancer Effect of a Novel Proteasome Inhibitor, YSY01A, via G2/M Arrest in PC-3M Cells in vitro and in vivo
Mei Zhang, Xia Yuan, Bo Xu, Wei Guo, Fu-Xiang Ran, Run-Tao Li, Jing-Rong Cui
J. Cancer 2015; 6(8): 701-708. doi:10.7150/jca.11785
[Abstract] [Full text] [PDF]

Review
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis
Xiu-Min Li, Hui Wang, Li-Li Zhu, Run-Zhen Zhao, Hong-Long Ji
J. Cancer 2015; 6(8): 694-700. doi:10.7150/jca.11709
[Abstract] [Full text] [PDF]

Research Paper
Bone Density in Patients with Cervical Cancer or Endometrial Cancer in comparison with Healthy Control; According to the stages
Yubin Lee, Ari Kim, Heung Yeol Kim, Wan Kyu Eo, Eun Sil Lee, Sungwook Chun
J. Cancer 2015; 6(8): 686-693. doi:10.7150/jca.11490
[Abstract] [Full text] [PDF]

Research Paper
Annexin A3 Is a Potential Predictor of Platinum Resistance in Epithelial Ovarian Cancer Patients in a Prospective Cohort
Ying Jin, Li-ping Feng, Xiang Jiang, Yong-xue Wang, Jie Yin, Zi-ping Yang, Yan Li, Ling-ya Pan
J. Cancer 2015; 6(7): 678-685. doi:10.7150/jca.11689
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
A MicroRNA Expression Signature In Taxane-anthracycline-Based Neoadjuvant Chemotherapy Response
Yi Zheng, Shuai Li, Rebecca J Boohaker, Xinli Liu, Yufen Zhu, Lili Zhai, Huilan Li, Feng Gu, Yu Fan, Ronggang Lang, Fangfang Liu, Xiaolong Qian, Bo Xu, Li Fu
J. Cancer 2015; 6(7): 671-677. doi:10.7150/jca.11616
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Galactose as Broad Ligand for Multiple Tumor Imaging and Therapy
Yuxiang Ma, Haiyan Chen, Shanyuhan Su, Tong Wang, Congying Zhang, Guissi Fida, Sisi Cui, Juan Zhao, Yueqing Gu
J. Cancer 2015; 6(7): 658-670. doi:10.7150/jca.11647
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Comparison of the RECIST 1.0 and RECIST 1.1 in Non-Small Cell Lung Cancer Treated with Cytotoxic Chemotherapy
Hyun Chang Choi, Jung Han Kim, Hyeong Su Kim, Soong Goo Jung, Sang Muk Hwang, Sung Bae Ju, Ik Yang
J. Cancer 2015; 6(7): 652-657. doi:10.7150/jca.11794
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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