Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Review
Weaknesses and Pitfalls of Using Mice and Rats in Cancer Chemoprevention Studies
Yukui Ma, Yuping Jia, Lichan Chen, Lewis Ezeogu, Baofa Yu, Ningzhi Xu, D. Joshua Liao
J. Cancer 2015; 6(10): 1058-1065. doi:10.7150/jca.12519
[Abstract] [Full text] [PDF]

Research Paper
Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44+/CD24-) in MCF-7 by Upregulating Mucin1 and EpCAM
Na Zhou, Rong Wang, Yizhuang Zhang, Zhen Lei, Xuehui Zhang, Ruobi Hu, Hui Li, Yiqing Mao, Xi Wang, David M. Irwin, Gang Niu, Huanran Tan
J. Cancer 2015; 6(10): 1049-1057. doi:10.7150/jca.12501
[Abstract] [Full text] [PDF]

Research Paper
A Muti-center, Randomized Phase II Study of Oxaliplatin and S-1 versus Capecitabine and Oxaliplatin in Patients with Metastatic Colorectal Cancer
Jung Han Kim, Dae Young Zang, Ik-Joo Chung, Sang-Hee Cho, Keon Uk Park, Ho-Suck Oh, Kyung Hee Lee, Bong Hwa Lee, Min-Jeong Kim, Choong Kee Park, Boram Han, Hyeong Su Kim, Dae Ro Choi, Hun Ho Song, Joo Young Jung
J. Cancer 2015; 6(10): 1041-1048. doi:10.7150/jca.12819
[Abstract] [Full text] [PDF]

Research Paper
The Expression and Function of NUMB in Endometrial Cancer and the Interaction with HDM2 and P53
Chao Wang, Weiwei Feng, Chuyao Zhang
J. Cancer 2015; 6(10): 1030-1040. doi:10.7150/jca.11970
[Abstract] [Full text] [PDF]

Research Paper
The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells
Buket Reel, Ceren Gonen Korkmaz, Mehmet Zuhuri Arun, Gokce Yildirim, Deniz Ogut, Aysegul Kaymak, Serap Cilaker Micili, Bekir Ugur Ergur
J. Cancer 2015; 6(10): 1020-1029. doi:10.7150/jca.12733
[Abstract] [Full text] [PDF]

Research Paper
Solanum Incanum Extract Downregulates Aldehyde Dehydrogenase 1-Mediated Stemness and Inhibits Tumor Formation in Ovarian Cancer Cells
Yi-Hui Wu, Wen-Tai Chiu, Ming-Jer Young, Tzu-Hao Chang, Yu-Fang Huang, Cheng-Yang Chou
J. Cancer 2015; 6(10): 1011-1019. doi:10.7150/jca.12738
[Abstract] [Full text] [PDF]

Research Paper
Akt and Hippo Pathways in Ewing's Sarcoma Tumors and Their Prognostic Significance
Atif A. Ahmed, Malak Abedalthagafi, Ahmed E. Anwar, Marilyn M. Bui
J. Cancer 2015; 6(10): 1005-1010. doi:10.7150/jca.12703
[Abstract] [Full text] [PDF]

Research Paper
The Histone Deacetylase Inhibitor Vaproic Acid Induces Cell Growth Arrest in Hepatocellular Carcinoma Cells via Suppressing Notch Signaling
Guangchun Sun, Lily V. Mackey, David H. Coy, Cui-Yun Yu, Lichun Sun
J. Cancer 2015; 6(10): 996-1004. doi:10.7150/jca.12135
[Abstract] [Full text] [PDF]

Research Paper
Increased Expression of Eps15 Homology Domain 1 is Associated with Poor Prognosis in Resected Small Cell Lung Cancer
Qingwei Meng, Weiling Sun, Man Li, Yanbin Zhao, Xuesong Chen, Lichun Sun, Li Cai
J. Cancer 2015; 6(10): 990-995. doi:10.7150/jca.11650
[Abstract] [Full text] [PDF]

Research Paper
Mutation Analysis of Nine Chordoma Specimens by Targeted Next-Generation Cancer Panel Sequencing
Carina Fischer, Susanne Scheipl, Agnes Zopf, Norbert Niklas, Alexander Deutsch, Mette Jorgensen, Birgit Lohberger, Elke Verena Froehlich, Andreas Leithner, Christian Gabriel, Bernadette Liegl-Atzwanger, Beate Rinner
J. Cancer 2015; 6(10): 984-989. doi:10.7150/jca.11371
[Abstract] [Full text] [PDF]

Research Paper
Bioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model
Marco Tatullo, Massimo Marrelli, Massimiliano Amantea, Francesco Paduano, Luigi Santacroce, Stefano Gentile, Salvatore Scacco
J. Cancer 2015; 6(10): 976-983. doi:10.7150/jca.11936
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Impact of ABO Blood Group on the Survival in Patients with Ovarian Cancer
Juan Zhou, Li-Chao Yang, Zhen-Yu He, Fang-Yan Li, San-Gang Wu, Jia-Yuan Sun
J. Cancer 2015; 6(10): 970-975. doi:10.7150/jca.12471
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Interleukin 37 Expression Inhibits STAT3 to Suppress the Proliferation and Invasion of Human Cervical Cancer Cells
Sen Wang, Weifang An, Yunhong Yao, Renhuai Chen, Xiaoxuan Zheng, Wanyong Yang, Yi Zhao, Xinrong Hu, Enping Jiang, Yanhong Bie, Zhangquan Chen, Ping Ouyang, He Zhang, Hui Xiong
J. Cancer 2015; 6(10): 962-969. doi:10.7150/jca.12266
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Loss of IRF8 Inhibits the Growth of Diffuse Large B-cell Lymphoma
Yulian Xu, Lei Jiang, Jianchen Fang, Rong Fang, Herbert C. Morse, Guifang Ouyang, Jeff X. Zhou
J. Cancer 2015; 6(10): 953-961. doi:10.7150/jca.12067
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Role of Chemokines in Non-Small Cell Lung Cancer: Angiogenesis and Inflammation
Selma Rivas-Fuentes, Alfonso Salgado-Aguayo, Silvana Pertuz Belloso, Patricia Gorocica Rosete, Noé Alvarado-Vásquez, Guillermo Aquino-Jarquin
J. Cancer 2015; 6(10): 938-952. doi:10.7150/jca.12286
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor
Jin Wang, Bin Yan, Song-Mei Liu, Huanhuan Sun, Yonglong Pan, Daogang Guan, Xiaoyan Zhang, Jianqing Xu, Haiqing Ma
J. Cancer 2015; 6(10): 930-937. doi:10.7150/jca.12284
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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