Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Short Research Communication
Synonymous Polymorphisms in HOXB13 as a Protective Factor for Prostate Cancer
Ferras Albitar, Kevin Diep, Wanlong Ma, Maher Albitar
J. Cancer 2015; 6(5): 409-411. doi:10.7150/jca.11413
[Abstract] [Full text] [PDF]

Research Paper
Multiplex Ligation-dependent Probe Amplification Can Clarify HER2 Status in Gastric Cancers with “Polysomy 17”
Tao Wang, Yutaka Amemiya, Pauline Henry, Arun Seth, Wedad Hanna, Eugene T. Hsieh
J. Cancer 2015; 6(5): 403-408. doi:10.7150/jca.11424
[Abstract] [Full text] [PDF]

Research Paper
Clinical Implication of Performance Status in Patients with Hepatocellular Carcinoma Complicating with Cirrhosis
Hiroki Nishikawa, Ryuichi Kita, Toru Kimura, Yoshiaki Ohara, Azusa Sakamoto, Sumio Saito, Norihiro Nishijima, Akihiro Nasu, Hideyuki Komekado, Yukio Osaki
J. Cancer 2015; 6(4): 394-402. doi:10.7150/jca.11212
[Abstract] [Full text] [PDF]

Research Paper
Comparison of RECIST 1.0 and RECIST 1.1 in Patients with Metastatic Cancer: A Pooled Analysis
Jung Han Kim, Seon Jeong Min, Hyun Joo Jang, Ji Woong Cho, Su Ho Kim, Hyeong Su Kim
J. Cancer 2015; 6(4): 387-393. doi:10.7150/jca.11316
[Abstract] [Full text] [PDF]

Short Research Communication
The Effect of Tumor Microenvironment on Autophagy and Sensitivity to Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma
Yuan-Yuan Li, Sze-Kwan Lam, Chun-Yan Zheng, James Chung-Man Ho
J. Cancer 2015; 6(4): 382-386. doi:10.7150/jca.11187
[Abstract] [Full text] [PDF]

Research Paper
Tailoring Pelvic Lymphadenectomy for Patients with Stage IA2, IB1, and IIA1 Uterine Cervical Cancer
Juan Zhou, Jing Ran, Zhen-Yu He, Song Quan, Qiong-Hua Chen, San-Gang Wu, Jia-Yuan Sun
J. Cancer 2015; 6(4): 377-381. doi:10.7150/jca.10968
[Abstract] [Full text] [PDF]

Research Paper
Clinical Significance of Female-hormones and Cytokines in Breast Cancer Patients Complicated with Aromatase Inhibitor-related Osteoarthropathy - Efficacy of Vitamin E
Anna Kiyomi, Masujiro Makita, Takuji Iwase, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Hironori Takeuchi, Toshihiko Hirano
J. Cancer 2015; 6(4): 367-376. doi:10.7150/jca.10695
[Abstract] [Full text] [PDF]

Research Paper
Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?
Kalliopi Domvri, Dimitrios Bougiouklis, Paul Zarogoulidis, Konstantinos Porpodis, Manolis Xristoforidis, Alexandra Liaka, Ellada Eleutheriadou, Sofia Lampaki, George Lazaridis, John Organtzis, George Kyriazis, Wolfgang Hohenforst-Schmidt, Katerina Tsirgogianni, Vasilis Karavasilis, Sofia Baka, Kaid Darwiche, Lutz Freitag, Georgia Trakada, Konstantinos Zarogoulidis
J. Cancer 2015; 6(4): 360-366. doi:10.7150/jca.11308
[Abstract] [Full text] [PDF]

Research Paper
Expression and Function of HAX-1 in Human Cutaneous Squamous Cell Carcinoma
Xingyu Li, Tiejun Li, Bo You, Yin Shan, Si Shi, Xiaolei Cao, Li Qian
J. Cancer 2015; 6(4): 351-359. doi:10.7150/jca.11093
[Abstract] [Full text] [PDF]

Research Paper
Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer
Yingjun Quan, Ming Xu, Peng Cui, Min Ye, Biao Zhuang, Zhijun Min
J. Cancer 2015; 6(4): 342-350. doi:10.7150/jca.10969
[Abstract] [Full text] [PDF]

Research Paper
Expression and Splice Variant Analysis of Human TCF4 Transcription Factor in Esophageal Cancer
Gang He, Xingying Guan, Xuedan Chen, Yan Wang, Chao Luo, Bo Zhang
J. Cancer 2015; 6(4): 333-341. doi:10.7150/jca.10565
[Abstract] [Full text] [PDF]

Research Paper
Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells
Yue Xi, Hang Gao, Michael U. Callaghan, Andrew M. Fribley, Danielle M. Garshott, Zhi-Xiang Xu, Qinghua Zeng, Yu-Lin Li
J. Cancer 2015; 6(4): 327-332. doi:10.7150/jca.11185
[Abstract] [Full text] [PDF]

Research Paper
YSY01A, a Novel Proteasome Inhibitor, Induces Cell Cycle Arrest on G2 Phase in MCF-7 Cells via ERα and PI3K/Akt Pathways
Bingjie Xue, Wei Huang, Xia Yuan, Bo Xu, Yaxin Lou, Quan Zhou, Fuxiang Ran, Runtao Li, Jingrong Cui, Zemei Ge
J. Cancer 2015; 6(4): 319-326. doi:10.7150/jca.10733
[Abstract] [Full text] [PDF]

Research Paper
Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer
Takahiro Kogawa, Tamer M. Fouad, Caimiao Wei, Hiroko Masuda, Kazuharu Kai, Takeo Fujii, Randa El-Zein, Mariana Chavez-MacGregor, Jennifer K. Litton, Abenaa Brewster, Ricardo H. Alvarez, Gabriel N. Hortobagyi, Vicente Valero, Richard Theriault, Naoto T. Ueno
J. Cancer 2015; 6(4): 310-318. doi:10.7150/jca.10580
[Abstract] [Full text] [PDF]

Research Paper
Association between CYP1A1 Ile462Val Polymorphism and Oral Squamous Cell Carcinoma Susceptibility: Evidence from 13 Investigations
Xiao-Lei Yang, Shang Xie, Yi-Yan Jiang, Chang Shi, Zhi-Gang Cai, Su-Xiu Chen
J. Cancer 2015; 6(4): 302-309. doi:10.7150/jca.11036
[Abstract] [Full text] [PDF]

Research Paper
Controlling RECK miR21 Promotes Tumor Cell Invasion and Is Related to Biochemical Recurrence in Prostate Cancer
Katia R. M. Leite, Sabrina T. Reis, Nayara Viana, Denis R. Morais, Caio M. Moura, Iran A. Silva, José Pontes Jr, Betina Katz, Miguel Srougi
J. Cancer 2015; 6(3): 292-301. doi:10.7150/jca.11038
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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