Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.


Review
Current Status of Immune Checkpoint Inhibitors in Gastrointestinal Cancers
Bum Jun Kim, Hyun Joo Jang, Hyeong Su Kim, Jung Han Kim
J. Cancer 2017; 8(8): 1460-1465. doi:10.7150/jca.18470
[Abstract] [Full text] [PDF]

Hypothesis
ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC
Darina Lazarova, Michael Bordonaro
J. Cancer 2017; 8(8): 1453-1459. doi:10.7150/jca.18762
[Abstract] [Full text] [PDF]

Research Paper
Towards Prognostic Profiling of Non-Small Cell Lung Cancer: New Perspectives on the Relevance of Polo-Like Kinase 1 Expression, the TP53 Mutation Status and Hypoxia
Jolien Van den Bossche, Christophe Deben, Ken Op de Beeck, Vanessa Deschoolmeester, Christophe Hermans, Ines De Pauw, Julie Jacobs, Paul Van Schil, Jan Baptist Vermorken, Patrick Pauwels, Marc Peeters, Filip Lardon, An Wouters
J. Cancer 2017; 8(8): 1441-1452. doi:10.7150/jca.18455
[Abstract] [Full text] [PDF]

Research Paper
Anti-Metastatic Effect of Semi-Purified Nuphar Lutea Leaf Extracts
Janet Ozer, Daniel Fishman, Brit Eilam, Avi Golan-Goldhirsh, Jacob Gopas
J. Cancer 2017; 8(8): 1433-1440. doi:10.7150/jca.18435
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of Coxsackie Adenovirus Receptor Sensitizes Cisplatin-Resistant Lung Cancer Cells to CRAd-Induced Inhibition
Ali Sakhawat, Yanan Liu, Ling Ma, Tahir Muhammad, Shensen Wang, Lina Zhang, Xianling Cong, Yinghui Huang
J. Cancer 2017; 8(8): 1425-1432. doi:10.7150/jca.18371
[Abstract] [Full text] [PDF]

Research Paper
Temozolomide and Bevacizumab Induction before Chemoradiotherapy in Patients with Bulky Glioblastoma and/or with Severe Neurological Impairment
Ilan Darmon, Mony Chenda Morisse, Alexandre Coutte, Marie Blonski, Emilie Le Rhun, Luc Taillandier, Diana Bello Roufai, Christine Desenclos, Stéphanie Trudel, Jean-Christophe Faivre, Nicolas Blanchard, Bruno Chauffert, Mathieu Boone
J. Cancer 2017; 8(8): 1417-1424. doi:10.7150/jca.18339
[Abstract] [Full text] [PDF]

Research Paper
The Prognostic and Predictive Value of Carbohydrate Antigen 19-9 in Metastatic Colorectal Cancer Patients with First Line Bevacizumab Containing Chemotherapy
Chang Jiang, Shousheng Liu, Wenzhuo He, Bei Zhang, Liangping Xia
J. Cancer 2017; 8(8): 1410-1416. doi:10.7150/jca.18325
[Abstract] [Full text] [PDF]

Research Paper
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells
You Wang, Liu Hu, Ximei Zhang, Hong Zhao, Hui Xu, Yuehua Wei, Huangang Jiang, Conghua Xie, Yunfeng Zhou, Fuxiang Zhou
J. Cancer 2017; 8(8): 1400-1409. doi:10.7150/jca.18170
[Abstract] [Full text] [PDF]

Research Paper
The Clinical Impact of c-MET Over-Expression in Advanced Biliary Tract Cancer (BTC)
Mi Hwa Heo, Hee Kyung Kim, Hansang Lee, Kyoung-Mee Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Seung Tae Kim
J. Cancer 2017; 8(8): 1395-1399. doi:10.7150/jca.17898
[Abstract] [Full text] [PDF]

Research Paper
Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability
Chao-Wen Hsu, Yu-Chia Chen, Hsing-Hao Su, Guan-Jin Huang, Chih-Wen Shu, Tony Tong-Lin Wu, Hung-Wei Pan
J. Cancer 2017; 8(8): 1378-1394. doi:10.7150/jca.17478
[Abstract] [Full text] [PDF]

Research Paper
Antiemetic Effectiveness and Cost-Saving of Aprepitant plus Granisetron Is Superior to Palonosetron in Gastrointestinal Cancer Patients Who Received Moderately Emetogenic Chemotherapy
Haruka Toda, Hitoshi Kawazoe, Akiko Yano, Yuji Yamamoto, Yuji Watanabe, Yasunori Yamamoto, Yoichi Hiasa, Yoshihiro Yakushijin, Akihiro Tanaka, Hiroaki Araki
J. Cancer 2017; 8(8): 1371-1377. doi:10.7150/jca.17102
[Abstract] [Full text] [PDF]

Research Paper
Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma
Ning Gan, Sihai Zou, Wenming Hang, Deqin Yang, Xuemei Zhang, Yibing Yin
J. Cancer 2017; 8(8): 1362-1370. doi:10.7150/jca.18031
[Abstract] [Full text] [PDF]

Research Paper
Plasma Mesothelin as a Novel Diagnostic and Prognostic Biomarker in Colorectal Cancer
Shuwei Li, Lisheng Xie, Lei He, Zhimin Fan, Junhua Xu, Kaili Xu, Lingjun Zhu, Gaoxiang Ma, Mulong Du, Haiyan Chu, Zhengdong Zhang, Min Ni, Meilin Wang
J. Cancer 2017; 8(8): 1355-1361. doi:10.7150/jca.18014
[Abstract] [Full text] [PDF]

Research Paper
Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer
Ji Ye Jung, Eun Young Kim, Arum Kim, Joon Chang, Nam Hoon Kwon, Youngji Moon, Eun Joo Kang, Jun Sik Sung, Hyunbo Shim, Sunghoon Kim, Yoon Soo Chang
J. Cancer 2017; 8(8): 1347-1354. doi:10.7150/jca.18450
[Abstract] [Full text] [PDF]

Research Paper
Serum IgG4:IgG Ratio Predicts Recurrence of Patients with Hepatocellular Carcinoma after Curative Resection
Jiong Wu, Xiao-Lu Ma, Lu Tian, Chun-Yan Zhang, Bei-Li Wang, Yu-Yi Hu, Xing-Hui Gao, Yan Zhou, Min-Na Shen, Yin-Fei Peng, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
J. Cancer 2017; 8(8): 1338-1346. doi:10.7150/jca.18030
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of Transcobalamin 1 is an Independent Negative Prognosticator in Rectal Cancers Receiving Concurrent Chemoradiotherapy
Yi-Ying Lee, Yu-Ching Wei, Yu-Feng Tian, Ding-Ping Sun, Ming-Jen Sheu, Ching-Chieh Yang, Li-Ching Lin, Chen-Yi Lin, Chung-Hsi Hsing, Wan-Shan Li, Chien-Feng Li, Pei-Ling Hsieh, Ching-Yih Lin
J. Cancer 2017; 8(8): 1330-1337. doi:10.7150/jca.18274
[Abstract] [Full text] [PDF]

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