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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Activated Tumor-infiltrating Fibroblasts Predict Worse Prognosis in Breast Cancer Patients
Guoming Hu, Feng Xu, Kefang Zhong, Shimin Wang, Liming Huang, Wei Chen
J. Cancer 2018; 9(20): 3736-3742. doi:10.7150/jca.28054
[Abstract] [Full text] [PDF]

Research Paper
Breast cancer stem cell markers CD44 and ALDH1A1 in serum: distribution and prognostic value in patients with primary breast cancer
Yanan Kong, Ning Lyu, Jiali Wu, Hailin Tang, Xinhua Xie, Lu Yang, Xing Li, Weidong Wei, Xiaoming Xie
J. Cancer 2018; 9(20): 3728-3735. doi:10.7150/jca.28032
[Abstract] [Full text] [PDF]

Short Research Communication
Nucleolar stress: is there a reverse version?
Lu Lu, Huimei Yi, Chao Chen, Shichao Yan, Hui Yao, Guangchun He, Guifei Li, Yiqun Jiang, Tuo Deng, Xiyun Deng
J. Cancer 2018; 9(20): 3723-3727. doi:10.7150/jca.27660
[Abstract] [Full text] [PDF]

Research Paper
LncRNA GACAT1 Promotes Gastric Cancer Cell Growth, Invasion And Migration By Regulating MiR-149-mediated Of ZBTB2 And SP1
Xiaoqing Shi, Xiaoqin Wang, Yimin Hua
J. Cancer 2018; 9(20): 3715-3722. doi:10.7150/jca.27546
[Abstract] [Full text] [PDF]

Letter
Preoperative Serum and Intra-platelet Serotonin in Prognosis: Useful or Useless?
Qinling Yang, Sushun Liu, Chaoling Deng, Bo Shu, Jingyao Zhang, Mimi Zhai
J. Cancer 2018; 9(20): 3713-3714. doi:10.7150/jca.27497
[Abstract] [Full text] [PDF]

Research Paper
Survival analysis for lung adenosquamous carcinoma patients with brain metastasis
Feng Pan, Shaohua Cui, Weimin Wang, Aiqin Gu, Liyan Jiang
J. Cancer 2018; 9(20): 3707-3712. doi:10.7150/jca.27441
[Abstract] [Full text] [PDF]

Review
Oncogenic virus-induced aerobic glycolysis and tumorigenesis
Li Yu, Xun Chen, Liantang Wang, Shangwu Chen
J. Cancer 2018; 9(20): 3699-3706. doi:10.7150/jca.27279
[Abstract] [Full text] [PDF]

Research Paper
The prognostic value of long noncoding RNA ZEB1-AS1 on clinical outcomes in human cancer
Ying Wu, Ming Ding, Shuzhen Wei, Ting Wu, Rongrong Xu, Xiaoli Zhu, Hongbing Liu
J. Cancer 2018; 9(20): 3690-3698. doi:10.7150/jca.27263
[Abstract] [Full text] [PDF]

Research Paper
How much margin do we need for pelvic lymph nodes irradiation in the era of IGRT?
Zhikai Liu, Xia Liu, Fuquan Zhang, Ke Hu
J. Cancer 2018; 9(20): 3683-3689. doi:10.7150/jca.27220
[Abstract] [Full text] [PDF]

Research Paper
Neoadjuvant Chemotherapy with Fluorouracil plus Nedaplatin or Cisplatin for Locally Advanced Nasopharyngeal Carcinoma: a Retrospective Study
Tongxin Liu, Quanquan Sun, Jing Chen, Bin Li, Weifeng Qin, Fangzheng Wang, Zhimin Ye, Fujun Hu
J. Cancer 2018; 9(20): 3676-3682. doi:10.7150/jca.27198
[Abstract] [Full text] [PDF]

Research Paper
Luteolin exerts an anticancer effect on gastric cancer cells through multiple signaling pathways and regulating miRNAs
Yansong Pu, Tao Zhang, Jianhua Wang, Zhijun Mao, Baojun Duan, Yanbin Long, Fei Xue, Dong Liu, Sida Liu, Zengzhan Gao
J. Cancer 2018; 9(20): 3669-3675. doi:10.7150/jca.27183
[Abstract] [Full text] [PDF]

Research Paper
MiR-543 promotes cell proliferation and metastasis of renal cell carcinoma by targeting Dickkopf 1 through the Wnt/β-catenin signaling pathway
Zhi-yuan Chen, Yang Du, Lei Wang, Xiu-heng Liu, Jia Guo, Xiao-dong Weng
J. Cancer 2018; 9(20): 3660-3668. doi:10.7150/jca.27124
[Abstract] [Full text] [PDF]

Research Paper
miRNA-21 and miRNA-223 expression signature as a predictor for lymph node metastasis, distant metastasis and survival in kidney renal clear cell carcinoma
Li Yu, Li Xiang, Jihua Feng, Bocheng Li, Zhibin Zhou, Ji Li, Yan Lin, Yufeng Lv, Donghua Zou, Zhuoqing Lei, Jianfeng Zhang
J. Cancer 2018; 9(20): 3651-3659. doi:10.7150/jca.27117
[Abstract] [Full text] [PDF]

Research Paper
Variants in the 3'-untranslated region of CUL3 is associated with risk of esophageal squamous cell carcinoma
Jin-Long Hu, Xin-Long Hu, Chuang-Xin Lu, Xue-Jiao Chen, Lei Fu, Qian Han, Shun-Dong Cang
J. Cancer 2018; 9(20): 3647-3650. doi:10.7150/jca.27052
[Abstract] [Full text] [PDF]

Research Paper
Somatic mutations, clinicopathologic characteristics, and survival in patients with untreated breast cancer with bone-only and non-bone sites of first metastasis
Miho Kono, Takeo Fujii, Naoko Matsuda, Kenichi Harano, Huiqin Chen, Chetna Wathoo, Aron Y. Joon, Debu Tripathy, Funda Meric-Bernstam, Naoto T. Ueno
J. Cancer 2018; 9(19): 3640-3646. doi:10.7150/jca.26825
[Abstract] [Full text] [PDF]

Research Paper
Risk of upgrading from prostate biopsy to radical prostatectomy pathology: Is magnetic resonance imaging-guided biopsy more accurate?
Ning Xu, Yu-Peng Wu, Xiao-Dong Li, Min-Yi Lin, Qing-Shui Zheng, Shao-Hao Chen, Jun-Feng Li, Yong Wei, Xue-Yi Xue
J. Cancer 2018; 9(19): 3634-3639. doi:10.7150/jca.26791
[Abstract] [Full text] [PDF]

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