Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor
Jin Wang, Bin Yan, Song-Mei Liu, Huanhuan Sun, Yonglong Pan, Daogang Guan, Xiaoyan Zhang, Jianqing Xu, Haiqing Ma
J. Cancer 2015; 6(10): 930-937. doi:10.7150/jca.12284
[Abstract] [Full text] [PDF]

Research Paper
Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma
Fumiaki Ochi, Atsushi Shiozaki, Daisuke Ichikawa, Hitoshi Fujiwara, Shingo Nakashima, Kenichi Takemoto, Toshiyuki Kosuga, Hirotaka Konishi, Shuhei Komatsu, Kazuma Okamoto, Mitsuo Kishimoto, Yoshinori Marunaka, Eigo Otsuji
J. Cancer 2015; 6(10): 922-929. doi:10.7150/jca.11269
[Abstract] [Full text] [PDF]

Research Paper
Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects
Xiao-Yan Bai, Xinjian Qu, Xiao Jiang, Zhaowei Xu, Yangyang Yang, Qiming Su, Miao Wang, Huijian Wu
J. Cancer 2015; 6(9): 913-921. doi:10.7150/jca.12162
[Abstract] [Full text] [PDF]

Research Paper
Initiate Tumors with Single Cell Spheres Formed in Serum-Containing Medium
Guozhou Zhang, Kun Xiong, Weiwei Ma, Wei Xu, Huihui Zeng
J. Cancer 2015; 6(9): 901-912. doi:10.7150/jca.11910
[Abstract] [Full text] [PDF]

Research Paper
GOLPH3L is a Novel Prognostic Biomarker for Epithelial Ovarian Cancer
Yanling Feng, Fan He, Huini Wu, He Huang, Lan Zhang, Xian Han, Jihong Liu
J. Cancer 2015; 6(9): 893-900. doi:10.7150/jca.11865
[Abstract] [Full text] [PDF]

Research Paper
Efficacy of the Additional Neoadjuvant Chemotherapy to Concurrent Chemoradiotherapy for Patients with Locoregionally Advanced Nasopharyngeal Carcinoma: a Bayesian Network Meta-analysis of Randomized Controlled Trials
Yu-Pei Chen, Rui Guo, Na Liu, Xu Liu, Yan-Ping Mao, Ling-Long Tang, Guan-Qun Zhou, Ai-Hua Lin, Ying Sun, Jun Ma
J. Cancer 2015; 6(9): 883-892. doi:10.7150/jca.11814
[Abstract] [Full text] [PDF]

Review
Argonaute 2: A Novel Rising Star in Cancer Research
ZhenLong Ye, HuaJun Jin, QiJun Qian
J. Cancer 2015; 6(9): 877-882. doi:10.7150/jca.11735
[Abstract] [Full text] [PDF]

Research Paper
Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells
Han-Ching Tseng, Akihito Inagaki, Vickie T. Bui, Nicholas Cacalano, Noriyuki Kasahara, Yan-gao Man, Anahid Jewett
J. Cancer 2015; 6(9): 866-876. doi:10.7150/jca.11527
[Abstract] [Full text] [PDF]

Research Paper
Ethnodrama: An Innovative Knowledge Translation Tool in the Management of Lymphedema
Shahid Ahmed, Elizabeth Quinlan, Linda McMullen, Roanne Thomas, Pam Fichtner, Janice Block
J. Cancer 2015; 6(9): 859-865. doi:10.7150/jca.12276
[Abstract] [Full text] [PDF]

Research Paper
Regulative Effect of Nampt on Tumor Progression and Cell Viability in Human Colorectal Cancer
Xiaoqun Lv, Lingyun Zhang, Yanyan Zhu, Harun M. Said, Jimin Shi, Guoxiong Xu
J. Cancer 2015; 6(9): 849-858. doi:10.7150/jca.12341
[Abstract] [Full text] [PDF]

Short Research Communication
Vasculature Disruption Enhances Bacterial Targeting of Autochthonous Tumors
Jeremy J. Drees, Michael J. Mertensotto, Lance B. Augustin, Janet L. Schottel, Daniel A. Saltzman
J. Cancer 2015; 6(9): 843-848. doi:10.7150/jca.12491
[Abstract] [Full text] [PDF]

Research Paper
Genetic Characterization of Ten-Eleven-Translocation Methylcytosine Dioxygenase Alterations in Human Glioma
Theo F. J. Kraus, Andrea Greiner, Martina Steinmaurer, Vanessa Dietinger, Virginie Guibourt, Hans A. Kretzschmar
J. Cancer 2015; 6(9): 832-842. doi:10.7150/jca.12010
[Abstract] [Full text] [PDF]

Short Research Communication
Hypothesis: Obesity Is Associated with a Lower Mutation Threshold in Colon Cancer
Michael Bordonaro, Darina Lazarova
J. Cancer 2015; 6(9): 825-831. doi:10.7150/jca.12352
[Abstract] [Full text] [PDF]

Research Paper
Promoter Hypermethylation in White Blood Cell DNA and Breast Cancer Risk
Yoon Hee Cho, Lauren E. McCullough, Marilie D. Gammon, Hui-Chen Wu, Yu-Jing Zhang, Qiao Wang, Xinran Xu, Susan L. Teitelbaum, Alfred I. Neugut, Jia Chen, Regina M. Santella
J. Cancer 2015; 6(9): 819-824. doi:10.7150/jca.12174
[Abstract] [Full text] [PDF]

Research Paper
The Prognostic Significance of Combining VEGFA, FLT1 and KDR mRNA Expressions in Brain Tumors
Shu-Dong Zhang, Ka Lai Leung, Cian M. McCrudden, Hang Fai Kwok
J. Cancer 2015; 6(9): 812-818. doi:10.7150/jca.11975
[Abstract] [Full text] [PDF]

Research Paper
Comparative Correlation Structure of Colon Cancer Locus Specific Methylation: Characterisation of Patient Profiles and Potential Markers across 3 Array-Based Datasets
Ana Barat, Heather J. Ruskin
J. Cancer 2015; 6(8): 795-811. doi:10.7150/jca.9883
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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