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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Nomogram for predicting level V lymph node metastases in papillary thyroid carcinoma with clinically lateral lymph node metastases: A large retrospective cohort study of 1037 patients from FDUSCC
Yunjun Wang, Qing Guan, Jun Xiang
J. Cancer 2019; 10(3): 772-778. doi:10.7150/jca.28527
[Abstract] [Full text] [PDF]

Research Paper
Can high school students help to improve breast radiologists in detecting missed breast cancer lesions on full-field digital mammography?
T.J.A. van Nijnatten, M.L. Smidt, B. Goorts, S. Samiei, I. Houben, E.M. Kok, J.E. Wildberger, S.G.F. Robben, M.B.I. Lobbes
J. Cancer 2019; 10(3): 765-771. doi:10.7150/jca.30494
[Abstract] [Full text] [PDF]

Research Paper
Oxidized Vitamin C (DHA) Overcomes Resistance to EGFR-targeted Therapy of Lung Cancer through Disturbing Energy Homeostasis
Mingtong Ye, Nengzhi Pang, Ting Wan, Yuanling Huang, Tianyi Wei, Xuye Jiang, Yujia Zhou, Yufeng Huang, Hainan Yang, Zhenfeng Zhang, Lili Yang
J. Cancer 2019; 10(3): 757-764. doi:10.7150/jca.28087
[Abstract] [Full text] [PDF]

Research Paper
High FOXM1 expression is a prognostic marker for poor clinical outcomes in prostate cancer
Mee Young Kim, Ae Ryang Jung, Ga Eun Kim, Jonghyup Yang, U-Syn Ha, Sung-Hoo Hong, Yeong Jin Choi, Mi Hyoung Moon, Sae Woong Kim, Ji Youl Lee, Yong Hyun Park
J. Cancer 2019; 10(3): 749-756. doi:10.7150/jca.28099
[Abstract] [Full text] [PDF]

Research Paper
Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis
Chunyan Zhang, Bin Lv, Cuihua Yi, Xiujie Cui, Shaofeng Sui, Xueen Li, Mei Qi, Chunyan Hao, Bo Han, Zhiyan Liu
J. Cancer 2019; 10(3): 737-748. doi:10.7150/jca.28111
[Abstract] [Full text] [PDF]

Research Paper
The survival benefit of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period consolidation chemotherapy in locally advanced rectal cancer
Rong Zheng, ShiFeng Lian, XiaoXue Huang, GuoXian Guan, XiaoBo Li, Pan Chi, BenHua Xu
J. Cancer 2019; 10(3): 730-736. doi:10.7150/jca.28265
[Abstract] [Full text] [PDF]

Review
The Oncogenic Potential of SUV39H2: A Comprehensive and Perspective View
Baihui Li, Yu Zheng, Lili Yang
J. Cancer 2019; 10(3): 721-729. doi:10.7150/jca.28254
[Abstract] [Full text] [PDF]

Review
New Prospect for Cancer Cachexia: Medical Cannabinoid
Jing Wang, Yanling Wang, Mengting Tong, Hongming Pan, Da Li
J. Cancer 2019; 10(3): 716-720. doi:10.7150/jca.28246
[Abstract] [Full text] [PDF]

Research Paper
Impact of clinical and pathological factors on local recurrence after breast-conserving treatment: CT-based localization for a tumor bed boost yielded better local control when compared with a surgical scar
Lize Wang, Jinfeng Li, Tianfeng Wang, Yuntao Xie, Zhaoqing Fan, Yingjian He, Tao Ouyang
J. Cancer 2019; 10(3): 708-715. doi:10.7150/jca.28328
[Abstract] [Full text] [PDF]

Research Paper
Multi-omics Perspective on the Tumor Microenvironment based on PD-L1 and CD8 T-Cell Infiltration in Urothelial Cancer
Siteng Chen, Ning Zhang, Jialiang Shao, Tao Wang, Xiang Wang
J. Cancer 2019; 10(3): 697-707. doi:10.7150/jca.28494
[Abstract] [Full text] [PDF]

Research Paper
Loss of Yes-associated Protein Represents an Aggressive Subtype of Colorectal Cancer
Sheng Zhang, Qing Wei, Yongzhi Yang, Huanlong Qin, Xinxiang Li, Sanjun Cai, Yanlei Ma
J. Cancer 2019; 10(3): 689-696. doi:10.7150/jca.28333
[Abstract] [Full text] [PDF]

Research Paper
Clinical Significance of Gender and Body Mass Index in Asian Patients with Colorectal Cancer
Chai Hong Rim, Chul Yong Kim, Dae Sik Yang, Won Sup Yoon
J. Cancer 2019; 10(3): 682-688. doi:10.7150/jca.28495
[Abstract] [Full text] [PDF]

Research Paper
Long noncoding RNA GIHCG functions as an oncogene and serves as a serum diagnostic biomarker for cervical cancer
Xiaolian Zhang, Lihua Mao, Lihua Li, Zhihong He, Naiqun Wang, Yanfeng Song
J. Cancer 2019; 10(3): 672-681. doi:10.7150/jca.28525
[Abstract] [Full text] [PDF]

Research Paper
Transarterial Chemoembolization related to Good Survival for Selected Patients with advanced Hepatocellular Carcinoma
Yong Le, Jing-Xian Shen, Yong-Fa Zhang, Min-Ke He, Anna Kan, Hai-Long Chen, Zi-Shan Yu, Qi-Jiong Li, Ming Shi
J. Cancer 2019; 10(3): 665-671. doi:10.7150/jca.28528
[Abstract] [Full text] [PDF]

Review
Prognostic and Clinicopathological Significance of MiR-155 in Hematologic Malignancies: A Systematic Review and Meta-analysis
Lu Tang, Yi-zhong Peng, Cheng-gong Li, Hui-wen Jiang, Heng Mei, Yu Hu
J. Cancer 2019; 10(3): 654-664. doi:10.7150/jca.28537
[Abstract] [Full text] [PDF]

Review
Advances in Identification of Susceptibility Gene Defects of Hereditary Colorectal Cancer
Qiang Liu, Yue-Qiu Tan
J. Cancer 2019; 10(3): 643-653. doi:10.7150/jca.28542
[Abstract] [Full text] [PDF]

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