Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 3.271 according to the 2015 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
P53 Is Involved in a Three-Dimensional Architecture-Mediated Decrease in Chemosensitivity in Colon Cancer
Jianming He, Xi Liang, Fen Luo, Xuedan Chen, Xueqing Xu, Fengchao Wang, Zhenping Zhang
J. Cancer 2016; 7(8): 900-909. doi:10.7150/jca.14506
[Abstract] [Full text] [PDF]

Research Paper
Less Invasive Endometrial Cancer Surgery with Extraperitoneal Pelvic and Para-aortic Lymphadenectomy via a Small Midline Abdominal Incision and the Retroperitoneal Approach
Shinichi Komiyama, Chiaki Takeya, Rena Takahashi, Sumito Nagasaki, Kaneyuki Kubushiro
J. Cancer 2016; 7(8): 890-899. doi:10.7150/jca.14987
[Abstract] [Full text] [PDF]

Research Paper
Radiotherapy and Sorafenib in the Management of Patients with Hepatocellular Carcinoma Have Led to Improved Survival: A Single Center Experience
Assaf Moore, Michal Cohen-Naftaly, Ofer Benjaminov, Marius Braun, Assaf Issachar, Eitan Mor, Anna Tovar, Michal Sarfaty, Noa Gordon, Salomon M. Stemmer
J. Cancer 2016; 7(8): 883-889. doi:10.7150/jca.14721
[Abstract] [Full text] [PDF]

Research Paper
Role of Four Different Kinds of Polyethylenimines (PEIs) in Preparation of Polymeric Lipid Nanoparticles and Their Anticancer Activity Study
Kongtong Yu, Jinlong Zhao, Changhui Yu, Fengying Sun, Yan Liu, Yang Zhang, Robert J. Lee, Lesheng Teng, Youxin Li
J. Cancer 2016; 7(7): 872-882. doi:10.7150/jca.13855
[Abstract] [Full text] [PDF]

Research Paper
ANG Promotes Proliferation and Invasion of the Cell of Lung Squamous Carcinoma by Directly Up-Regulating HMGA2
Li Xu, Wei-Lin Liao, Qi-Jue Lu, Chun-Guang Li, Yang Yuan, Zhi-Yun Xu, Sheng-Dong Huang, He-Zhong Chen
J. Cancer 2016; 7(7): 862-871. doi:10.7150/jca.14440
[Abstract] [Full text] [PDF]

Research Paper
Effect of Comorbidity on Postoperative Survival Outcomes in Patients with Solid Cancers: A 6-Year Multicenter Study in Taiwan
Wen-Chi Chou, Pei-Hung Chang, Chang-Hsien Lu, Keng-Hao Liu, Yu-Shin Hung, Chia-Yen Hung, Chien-Ting Liu, Kun-Yun Yeh, Yung-Chang Lin, Ta-Sen Yeh
J. Cancer 2016; 7(7): 854-861. doi:10.7150/jca.14777
[Abstract] [Full text] [PDF]

Research Paper
Combining Telomerase Reverse Transcriptase Genetic Variant rs2736100 with Epidemiologic Factors in the Prediction of Lung Cancer Susceptibility
Xu Wang, Kewei Ma, Lumei Chi, Jiuwei Cui, Lina Jin, Ji-Fan Hu, Wei Li
J. Cancer 2016; 7(7): 846-853. doi:10.7150/jca.13437
[Abstract] [Full text] [PDF]

Research Paper
Surgical Management of the Primary Tumor in Stage IV Colorectal Cancer: A Confirmatory Retrospective Cohort Study
Shahid Ahmed, Anne Leis, Selliah Chandra-Kanthan, Anthony Fields, Bruce Reeder, Nayyer Iqbal, Kamal Haider, Duc Le, Punam Pahwa
J. Cancer 2016; 7(7): 837-845. doi:10.7150/jca.14717
[Abstract] [Full text] [PDF]

Research Paper
The Reduction in Circulating Melatonin Level May Contribute to the Pathogenesis of Ovarian Cancer: A Retrospective Study
Min Zhao, Jiayi Wan, Ke Zeng, Mancy Tong, Arier C Lee, Jinxin Ding, Qi Chen
J. Cancer 2016; 7(7): 831-836. doi:10.7150/jca.14573
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Significance of Forkhead Box M1 (FOXM1) Expression and Antitumor Effect of FOXM1 Inhibition in Angiosarcoma
Takamichi Ito, Kenichi Kohashi, Yuichi Yamada, Takeshi Iwasaki, Akira Maekawa, Masaaki Kuda, Daichi Hoshina, Riichiro Abe, Masutaka Furue, Yoshinao Oda
J. Cancer 2016; 7(7): 823-830. doi:10.7150/jca.14461
[Abstract] [Full text] [PDF]

Review
Warburg Effect - a Consequence or the Cause of Carcinogenesis?
Slobodan Devic
J. Cancer 2016; 7(7): 817-822. doi:10.7150/jca.14274
[Abstract] [Full text] [PDF]

Research Paper
In Situ Characterizing Membrane Lipid Phenotype of Human Lung Cancer Cell Lines Using Mass Spectrometry Profiling
Manwen He, Shuai Guo, Junling Ren, Zhili Li
J. Cancer 2016; 7(7): 810-816. doi:10.7150/jca.14310
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA Expression Profiles in Papillary Thyroid Carcinoma, Benign Thyroid Nodules and Healthy Controls
Ebru Esin Yoruker, Duygu Terzioglu, Serkan Teksoz, Fatma Ezel Uslu, Ugur Gezer, Nejat Dalay
J. Cancer 2016; 7(7): 803-809. doi:10.7150/jca.13898
[Abstract] [Full text] [PDF]

Research Paper
Survival and Quality of Life Benefit after Endoscopic Management of Malignant Central Airway Obstruction
Grigoris Stratakos, Vasiliki Gerovasili, Charalampos Dimitropoulos, Ioannis Giozos, Filippos T. Filippidis, Sofia Gennimata, Paul Zarogoulidis, Athanasios Zissimopoulos, Athanasia Pataka, Nikos Koufos, Spyros Zakynthinos, Konstantinos Syrigos, Nikos Koulouris
J. Cancer 2016; 7(7): 794-802. doi:10.7150/jca.15097
[Abstract] [Full text] [PDF]

Research Paper
PD-L1 Expression Is Associated with Tumor FOXP3+ Regulatory T-Cell Infiltration of Breast Cancer and Poor Prognosis of Patient
Zhenhua Li, Pengzhi Dong, Meijing Ren, Yawen Song, Xiaolong Qian, Yiling Yang, Shuai Li, Xinmin Zhang, Fangfang Liu
J. Cancer 2016; 7(7): 784-793. doi:10.7150/jca.14549
[Abstract] [Full text] [PDF]

Research Paper
Phase I/II Trial Evaluating Carbon Ion Radiotherapy for Salvaging Treatment of Locally Recurrent Nasopharyngeal Carcinoma
Lin Kong, Jiyi Hu, Xiyin Guan, Jing Gao, Rong Lu, Jiade J. Lu
J. Cancer 2016; 7(7): 774-783. doi:10.7150/jca.14399
[Abstract] [Full text] [PDF]

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