Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
  • Indexed in SCI Expanded, PubMed and full texts in PubMed Central, Europe PubMed Central, and PMC Canada.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...

Journal of Cancer coverJournal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. Journal of Cancer is published in cooperation with American Registry of Pathology.

Latest papers:

Research Paper
The Cause and Prevention of Anastomotic Recurrence following Colectomy: An Immunohistochemical Approach for Detecting Transforming Colonocytes
Arlen M., Crawford J., Coppa G., Saric O., Bandovic J., Doubakovski A., Sullivan J., Conte C., Kadison A., Procaccino J., Arlen P., Wang X., Molmenti E.
J. Cancer 2014; 5(9): 784-789. doi:10.7150/jca.9485
[Abstract] [Full text] [PDF]

Research Paper
In Vivo Lymphatic Imaging of a Human Inflammatory Breast Cancer Model
Germaine D. Agollah, Grace Wu, Eva M. Sevick-Muraca, Sunkuk Kwon
J. Cancer 2014; 5(9): 774-783. doi:10.7150/jca.9835
[Abstract] [Full text] [PDF]

Review
Interleukin-7 and Interleukin-15 for Cancer
Paul Zarogoulidis, Sofia Lampaki, Lonny Yarmus, Ioannis Kioumis, Georgia Pitsiou, Nikolaos Katsikogiannis, Wolfgang Hohenforst-Schmidt, Qiang Li, Haidong Huang, Antonios Sakkas, John Organtzis, Leonidas Sakkas, Ioannis Mpoukovinas, Kosmas Tsakiridis, George Lazaridis, Konstantinos Syrigos, Konstantinos Zarogoulidis
J. Cancer 2014; 5(9): 765-773. doi:10.7150/jca.10471
[Abstract] [Full text] [PDF]

Short Research Communication
CD70: A Potential Target in Breast Cancer?
Camille Petrau, Marie Cornic, Philippe Bertrand, Catherine Maingonnat, Vinciane Marchand, Jean-Michel Picquenot, Fabrice Jardin, Florian Clatot
J. Cancer 2014; 5(9): 761-764. doi:10.7150/jca.10360
[Abstract] [Full text] [PDF]

Research Paper
Perineural Invasion and TAMs in Pancreatic Ductal Adenocarcinomas: Review of the Original Pathology Reports Using Immunohistochemical Enhancement and Relationships with Clinicopathological Features
Linjuan Zeng, Yubo Guo, Jianzhong Liang, Shaojie Chen, Peijian Peng, Qiubo Zhang, Hong Su, Yinting Chen, Kaihong Huang
J. Cancer 2014; 5(9): 754-760. doi:10.7150/jca.10238
[Abstract] [Full text] [PDF]

Research Paper
cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer
Joohyuk Sohn, Shuying Liu, Napa Parinyanitikul, Jangsoon Lee, Gabriel N. Hortobagyi, Gordon B. Mills, Naoto T. Ueno, Ana M. Gonzalez-Angulo
J. Cancer 2014; 5(9): 745-753. doi:10.7150/jca.9696
[Abstract] [Full text] [PDF]

Review
Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor behind the Scene
M. Akhtar Anwar, Wassim Abou Kheir, Stephanie Eid, Joanna Fares, Xiaoqi Liu, Ali H. Eid, Assaad A. Eid
J. Cancer 2014; 5(9): 736-744. doi:10.7150/jca.9726
[Abstract] [Full text] [PDF]

Research Paper
Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats
Grazielle M. Ferreira, Marcelo Martinez, Isabel Cristina C. Camargo, Raquel F. Domeniconi, Francisco Eduardo Martinez, Luiz Gustavo A. Chuffa
J. Cancer 2014; 5(9): 728-735. doi:10.7150/jca.10196
[Abstract] [Full text] [PDF]

Review
Utilization of Translational Bioinformatics to Identify Novel Biomarkers of Bortezomib Resistance in Multiple Myeloma
Deanna J. Fall, Holly Stessman, Sagar S. Patel, Zohar Sachs, Brian G. Van Ness, Linda B. Baughn, Michael A. Linden
J. Cancer 2014; 5(9): 720-727. doi:10.7150/jca.9864
[Abstract] [Full text] [PDF]

Review
Salamander Regeneration as a Model for Developing Novel Regenerative and Anticancer Therapies
Jonathan Fior
J. Cancer 2014; 5(8): 715-719. doi:10.7150/jca.9971
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Serum Unsaturated Free Fatty Acids: Potential Biomarkers for Early Detection and Disease Progression Monitoring of Non-Small Cell Lung Cancer
Yaping Zhang, Chengyan He, Ling Qiu, Yanmin Wang, Li Zhang, Xuzhen Qin, Yujie Liu, Dan Zhang, Zhili Li
J. Cancer 2014; 5(8): 706-714. doi:10.7150/jca.9787
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer
Jin Wang, Massimo Raimondo, Sushovan Guha, Jinyun Chen, Lixia Diao, Xiaoqun Dong, Michael B. Wallace, Ann M. Killary, Marsha L. Frazier, Timothy A. Woodward, Jing Wang, Subrata Sen
J. Cancer 2014; 5(8): 696-705. doi:10.7150/jca.10094
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Modified Glasgow Prognostic Score Is an Independent Prognostic Factor in Patients with Inoperable Thoracic Esophageal Squamous Cell Carcinoma Undergoing Chemoradiotherapy
Peng Zhang, Mian Xi, Qiao-Qiao Li, Li-Ru He, Shi-Liang Liu, Lei Zhao, Jing-Xian Shen, Meng-Zhong Liu
J. Cancer 2014; 5(8): 689-695. doi:10.7150/jca.9569
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Photothermal Treatment of Human Pancreatic Cancer Using PEGylated Multi-Walled Carbon Nanotubes Induces Apoptosis by Triggering Mitochondrial Membrane Depolarization Mechanism
Teodora Mocan, Cristian T. Matea, Iulia Cojocaru, Ioana Ilie, Flaviu A. Tabaran, Florin Zaharie, Cornel Iancu, Dana Bartos, Lucian Mocan
J. Cancer 2014; 5(8): 679-688. doi:10.7150/jca.9481
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Preferential Effect of Akt2-Dependent Signaling on the Cellular Viability of Ovarian Cancer Cells in Response to EGF
Dineo Khabele, Syeda M Kabir, Yuanlin Dong, Eunsook Lee, Valerie Montgomery Rice, Deok-Soo Son
J. Cancer 2014; 5(8): 670-678. doi:10.7150/jca.9688
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Serum Carcinoembryonic Antigen Levels and the Risk of Whole-body Metastatic Potential in Advanced Non-small Cell Lung Cancer
Dong Soo Lee, Seung Joon Kim, Jin Hyoung Kang, Sook Hee Hong, Eun Kyoung Jeon, Young Kyoon Kim, Ie Ryoung Yoo, Jae Gil Park, Hong Seok Jang, Hyo Chun Lee, Yeon Sil Kim
J. Cancer 2014; 5(8): 663-669. doi:10.7150/jca.9871
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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