Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
new Oncomedicine now accepts submissions.

Cover suggestion ...details

Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
Cover image

Research Paper
Serum Pre-Albumin Predicts the Clinical Outcome in Metastatic Castration-Resistant Prostate Cancer Patients Treated With Abiraterone
Liancheng Fan, Chenfei Chi, Sanwei Guo, Yanqing Wang, Wen Cai, Xiaoguang Shao, Fan Xu, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Hongyang Qian, Shaowei Xie, Rui Wang, Lixin Zhou, Baijun Dong, Wei Xue
J. Cancer 2017; 8(17): 3448-3455. doi:10.7150/jca.21134
[Abstract] [Full text] [PDF]

Research Paper
Comparative Outcomes of Induction Chemotherapy Followed By Definitive Chemoradiotherapy versus Chemoradiotherapy Alone In Esophageal Squamous Cell Carcinoma
Li-Ling Luo, Mian Xi, Ya-Di Yang, Qiao-Qiao Li, Lei Zhao, Peng Zhang, Shi-Liang Liu, Meng-Zhong Liu
J. Cancer 2017; 8(17): 3441-3447. doi:10.7150/jca.21131
[Abstract] [Full text] [PDF]

Review
The Glycolytic Switch in Tumors: How Many Players Are Involved?
Li Yu, Xun Chen, Xueqi Sun, Liantang Wang, Shangwu Chen
J. Cancer 2017; 8(17): 3430-3440. doi:10.7150/jca.21125
[Abstract] [Full text] [PDF]

Research Paper
Phycocyanin: A Potential Drug for Cancer Treatment
Liangqian Jiang, Yujuan Wang, Qifeng Yin, Guoxiang Liu, Huihui Liu, Yajing Huang, Bing Li
J. Cancer 2017; 8(17): 3416-3429. doi:10.7150/jca.21058
[Abstract] [Full text] [PDF]

Research Paper
The Effect of CA125 Nadir Level on Survival of Advanced-Stage Epithelial Ovarian Carcinoma after Interval Debulking Surgery
Jing Zeng, Huizhen Huang, Ying Shan, Yan Li, Ying Jin, Lingya Pan
J. Cancer 2017; 8(17): 3410-3415. doi:10.7150/jca.21362
[Abstract] [Full text] [PDF]

Research Paper
p300 Knockout Promotes Butyrate Resistance
Darina L. Lazarova, Michael Bordonaro
J. Cancer 2017; 8(17): 3405-3409. doi:10.7150/jca.21145
[Abstract] [Full text] [PDF]

Research Paper
Clinicopathological Characteristics and Prognostic Value of Signet Ring Cells in Gastric Carcinoma: A Meta-Analysis
Run-Cong Nie, Shu-Qiang Yuan, Yuan-Fang Li, Yong-Ming Chen, Xiao-Jiang Chen, Bao-Yan Zhu, Li-Pu Xu, Zhi-Wei Zhou, Shi Chen, Ying-Bo Chen
J. Cancer 2017; 8(17): 3396-3404. doi:10.7150/jca.21017
[Abstract] [Full text] [PDF]

Research Paper
Linking Gut Microbiota to Colorectal Cancer
Hans Raskov, Jakob Burcharth, Hans-Christian Pommergaard
J. Cancer 2017; 8(17): 3378-3395. doi:10.7150/jca.20497
[Abstract] [Full text] [PDF]

Research Paper
Phosphorylated Protein Kinase C (Zeta/Lambda) Expression in Colorectal Adenocarcinoma and Its Correlation with Clinicopathologic Characteristics and Prognosis
Min-kyung Yeo, Ji Yeon Kim, In-ock Seong, Jin-Man Kim, Kyung-Hee Kim
J. Cancer 2017; 8(16): 3371-3377. doi:10.7150/jca.20983
[Abstract] [Full text] [PDF]

Research Paper
Alkaline Phosphatase-To-Albumin Ratio as a Prognostic Indicator in Pancreatic Ductal Adenocarcinoma after Curative Resection
Ning Pu, Shanshan Gao, Yadong Xu, Guochao Zhao, Yang Lv, Abulimiti Nuerxiati, Jian-ang Li, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Xiaolin Wang, Wenhui Lou, Lingxiao Liu, Wenchuan Wu
J. Cancer 2017; 8(16): 3362-3370. doi:10.7150/jca.20917
[Abstract] [Full text] [PDF]

Research Paper
Distant Metastasis and Survival Outcomes after Computed Tomography-Guided Needle Biopsy in Resected Stage I-III Non-Small Cell Lung Cancer
Yuhui Xi, Jingli Fan, Dehai Che, Keke Zhai, Tingting Ren, Xiao Feng, Lihua Shang, Jing Hu, Yan Yu, Qingwei Meng
J. Cancer 2017; 8(16): 3356-3361. doi:10.7150/jca.20784
[Abstract] [Full text] [PDF]

Research Paper
The Prognostic Value of Peripheral Benzodiazepine Receptor in Patients with Esophageal Squamous Cell Carcinoma
You-Fang Chen, Jing-Dun Xie, Yu-Chuan Jiang, Dong-Tai Chen, Jia-Hao Pan, Yong-Hua Chen, Yun-Fei Yuan, Zhe-Sheng Wen, Wei-An Zeng
J. Cancer 2017; 8(16): 3343-3355. doi:10.7150/jca.20739
[Abstract] [Full text] [PDF]

Research Paper
Correlation of ALDH1 and Notch3 Expression: Clinical implication in Ovarian Carcinomas
Mi Joung Kim, A-Ram Kim, Ju-Yeon Jeong, Kwang-il Kim, Tae-Heon Kim, Chan Lee, Kwanghoe Chung, Young-Hyeh Ko, Hee-Jung An
J. Cancer 2017; 8(16): 3331-3342. doi:10.7150/jca.18955
[Abstract] [Full text] [PDF]

Research Paper
Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53
Keli Chen, Fengjiao Zhang, Jie Ding, Yonghao Liang, Zetao Zhan, Yizhi Zhan, Long-hua Chen, Yi Ding
J. Cancer 2017; 8(16): 3318-3330. doi:10.7150/jca.20482
[Abstract] [Full text] [PDF]

Research Paper
Heparanase Contributes To Trans-Endothelial Migration of Hepatocellular Carcinoma Cells
Xiaopeng Chen, Wen Jiang, Chaofu Yue, Wenjun Zhang, Chaogang Tong, Dafei Dai, Bin Cheng, Chen Huang, Linming Lu
J. Cancer 2017; 8(16): 3309-3317. doi:10.7150/jca.20159
[Abstract] [Full text] [PDF]

Research Paper
Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis
Pengfei Kong, Ruiyan Wu, Yadong Lan, Wenzhuo He, Chenlu Yang, Chenxi Yin, Qiong Yang, Chang Jiang, Dazhi Xu, Liangping Xia
J. Cancer 2017; 8(16): 3296-3308. doi:10.7150/jca.19810
[Abstract] [Full text] [PDF]

More ...