Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Predictors that Influence Election of Contralateral Prophylactic Mastectomy among Women with Ductal Carcinoma in Situ who are BRCA-Negative
Nisreen Elsayegh, Jessica Profato, Angelica M. Gutierrez Barrera, Heather Lin, Henry M. Kuerer, Can Ardic, Jennifer K. Litton, Debasish Tripathy, Banu K. Arun
J. Cancer 2015; 6(7): 610-615. doi:10.7150/jca.11710
[Abstract] [Full text] [PDF]

Review
Intercellular Signaling in Cancer—the SMT and TOFT Hypotheses, Exosomes, Telocytes and Metastases: Is the Messenger in the Message?
John Smythies
J. Cancer 2015; 6(7): 604-609. doi:10.7150/jca.12372
[Abstract] [Full text] [PDF]

Research Paper
Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone
André Luis Giacometti Conceição, Erica Babeto, Natalia Maria Candido, Fernanda Craveiro Franco, Débora Aparecida Pires de Campos Zuccari, Jane Lopes Bonilha, José Antônio Cordeiro, Marilia Freitas Calmon, Paula Rahal
J. Cancer 2015; 6(7): 593-603. doi:10.7150/jca.11238
[Abstract] [Full text] [PDF]

Research Paper
In Vitro Administration of Gold Nanoparticles Functionalized with MUC-1 Protein Fragment Anticancer Vaccine Response via Macrophage Activation and Polarization Mechanism
Teodora Mocan, Cristian Matea, Flaviu Tabaran, Cornel Iancu, Remus Orasan, Lucian Mocan
J. Cancer 2015; 6(6): 583-592. doi:10.7150/jca.11567
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Effect of Targeted Agents on the Endocrine Response of Breast Cancer in the Neoadjuvant Setting: A Systematic Review
Antonino Grassadonia, Marta Caporale, Nicola Tinari, Marinella Zilli, Michele DeTursi, Teresa Gamucci, Patrizia Vici, Clara Natoli
J. Cancer 2015; 6(6): 575-582. doi:10.7150/jca.11566
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Defining the Role of Tyrosine Kinase Inhibitors in Early Stage Non-Small Cell Lung Cancer
Sofia Lampaki, George Lazaridis, Konstantinos Zarogoulidis, Ioannis Kioumis, Antonis Papaiwannou, Katerina Tsirgogianni, Anastasia Karavergou, Theodora Tsiouda, Vasilis Karavasilis, Lonny Yarmus, Kaid Darwiche, Lutz Freitag, Antonios Sakkas, Angeliki Kantzeli, Sofia Baka, Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis
J. Cancer 2015; 6(6): 568-574. doi:10.7150/jca.11893
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers
Zhiyu Peng, Chengfu Yuan, Lucas Zellmer, Siqi Liu, Ningzhi Xu, D. Joshua Liao
J. Cancer 2015; 6(6): 555-567. doi:10.7150/jca.11997
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Global DNA Methylation, Measured by the Luminometric Methylation Assay (LUMA), Associates with Postmenopausal Breast Cancer in Non-Obese and Physically Active Women
Lauren E. McCullough, Jia Chen, Alexandra J. White, Xinran Xu, Yoon Hee Cho, Patrick T. Bradshaw, Sybil M. Eng, Susan L. Teitelbaum, Mary Beth Terry, Gail Garbowski, Alfred I. Neugut, Hanina Hibshoosh, Regina M. Santella, Marilie D. Gammon
J. Cancer 2015; 6(6): 548-554. doi:10.7150/jca.11359
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Overexpression of CUEDC2 Predicts Poor Prognosis in Ovarian Serous Carcinomas
Aichun Wang, Chao Guo, Yunfei Sun, Lijuan Lu, Yun Wang, Qiong Wang, Yan Zhang, Hui Zhang, Li Wang, Yiqun Gu, Aijun Liu
J. Cancer 2015; 6(6): 542-547. doi:10.7150/jca.11420
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
Mutual Regulation of FOXM1, NPM and ARF Proteins
Bulbul Pandit, Andrei L. Gartel
J. Cancer 2015; 6(6): 538-541. doi:10.7150/jca.11766
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Longitudinal FDG-PET Revealed Regional Functional Heterogeneity of Bone Marrow, Site-Dependent Response to Treatment and Correlation with Hematological Parameters
Masashi Yagi, Jerry Froelich, Luke Arentsen, Ryan Shanley, Rahel Ghebre, Douglas Yee, Susanta Hui
J. Cancer 2015; 6(6): 531-537. doi:10.7150/jca.11348
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Complement Receptor 1 Genetic Variants Contribute to the Susceptibility to Gastric Cancer in Chinese Population
Lina Zhao, Zhi Zhang, Jia Lin, Lei Cao, Bing He, Sugui Han, Xuemei Zhang
J. Cancer 2015; 6(6): 525-530. doi:10.7150/jca.10749
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C
Huilei Zhou, Lin Wang, Juxiang Huang, Minghu Jiang, Xiaoyu Zhang, Liyuan Zhang, Yangming Wang, Zhenfu Jiang, Zhongjie Zhang
J. Cancer 2015; 6(6): 519-524. doi:10.7150/jca.11404
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
TGF-β Induces Degradation of PTHrP through Ubiquitin-Proteasome System in Hepatocellular Carcinoma
Hao Li, Guangchun He, Hui Yao, Liujiang Song, Liang Zeng, Xiaoning Peng, Thomas J. Rosol, Xiyun Deng
J. Cancer 2015; 6(6): 511-518. doi:10.7150/jca.10830
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma
Xue-Xia Liang, Qun Li, Zhen Su, Xiao-Wen Lan, Pu-Yun Ouyang, Yan-Ping Mao, Ding-Bo Shi, Wu-Guo Deng, Zhi-Bin Cheng, Si-Yang Wang, Fang-Yun Xie
J. Cancer 2015; 6(6): 502-510. doi:10.7150/jca.11403
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Reconstitution of the ERG Gene Expression Network Reveals New Biomarkers and Therapeutic Targets in ERG Positive Prostate Tumors
Alexey Dubovenko, Tatiana Serebryiskaya, Yuri Nikolsky, Tatiana Nikolskaya, Ally Perlina, Lellean JeBailey, Svetlana Bureeva, Shilpa Katta, Shiv Srivastava, Albert Dobi, Tatiana Khasanova
J. Cancer 2015; 6(6): 490-501. doi:10.7150/jca.8213
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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