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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Addition of chemotherapy to intensity-modulated radiotherapy does not improve survival in stage II nasopharyngeal carcinoma patients
Wang Fangzheng, Jiang Chuner, Sun Quanquan, Ye Zhimin, Liu Tongxin, Liu Jiping, Masoto Sakamoto, Wu Peng, Shi Kaiyuan, Qin Weifeng, Fu Zhenfu, Jiang Yangming
J. Cancer 2018; 9(11): 2030-2037. doi:10.7150/jca.25042
[Abstract] [Full text] [PDF]

Research Paper
Higher Plasma Fibrinogen Levels are Associated with Malignant Phenotype and Worse Survival in Patients with Glioblastomas
Peng-Fei Wang, Zhe Meng, Hong-Wang Song, Kun Yao, Ze-Jun Duan, Shou-Wei Li, Chang-Xiang Yan
J. Cancer 2018; 9(11): 2024-2029. doi:10.7150/jca.24714
[Abstract] [Full text] [PDF]

Research Paper
SIRT1 promotes formation of breast cancer through modulating Akt activity
Xiaoxia Jin, Yingze Wei, Feng Xu, Min Zhao, Kui Dai, Rong Shen, Shuyun Yang, Nong Zhang
J. Cancer 2018; 9(11): 2012-2023. doi:10.7150/jca.24275
[Abstract] [Full text] [PDF]

Research Paper
Construction of a human monoclonal antibody against bFGF for suppression of NSCLC
Sheng Wang, Yiyang Qin, Zhongmin Wang, Junjian Xiang, Yu Zhang, Meng Xu, Baiyong Li, Yu Xia, Peng Zhang, Hong Wang
J. Cancer 2018; 9(11): 2003-2011. doi:10.7150/jca.24255
[Abstract] [Full text] [PDF]

Research Paper
Development Of A Three-Gene Prognostic Signature For Hepatitis B Virus Associated Hepatocellular Carcinoma Based On Integrated Transcriptomic Analysis
Yao Yang, Qian Lu, Xuejun Shao, Banghui Mo, Xuqiang Nie, Wei Liu, Xianhua Chen, Yuan Tang, Youcai Deng, Jun Yan
J. Cancer 2018; 9(11): 1989-2002. doi:10.7150/jca.23762
[Abstract] [Full text] [PDF]

Review
From First Line to Sequential Treatment in the Management of Metastatic Pancreatic Cancer
Andrés Muñoz Martín, Manuel Hidalgo, Rafael Alvarez, Virginia Arrazubi, Joaquina Martínez-Galán, Mercedes Salgado, Teresa Macarulla, Alfredo Carrato
J. Cancer 2018; 9(11): 1978-1988. doi:10.7150/jca.23716
[Abstract] [Full text] [PDF]

Research Paper
Aerosol Immunotherapy with or without Cisplatin for metastatic lung cancer non-small cell lung cancer disease: In vivo Study. A more efficient combination
Konstantinos Sapalidis, Paul Zarogoulidis, Efstathios Pavlidis, Stella Laskou, Athanasios Katsaounis, Charilaos Koulouris, Dimitrios Giannakidis, Stylianos Mantalovas, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Chrysanthi Sardeli, Aikaterini Amaniti, Ilias Karapantzos, Chrysanthi Karapantzou, Wolfgang Hohenforst-Schmidt, Fotis Konstantinou, Isaak Kesisoglou, Naim Benhanseen
J. Cancer 2018; 9(11): 1973-1977. doi:10.7150/jca.24782
[Abstract] [Full text] [PDF]

Review
Involvement of non-coding RNAs in chemotherapy resistance of ovarian cancer
Yang Shao, Hui Li, Ran Du, Jiao Meng, Gong Yang
J. Cancer 2018; 9(11): 1966-1972. doi:10.7150/jca.24550
[Abstract] [Full text] [PDF]

Research Paper
Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma
Marzena Garley, Dorota Dziemiańczyk-Pakieła, Kamil Grubczak, Arkadiusz Surażyński, Dorota Dąbrowska, Wioletta Ratajczak-Wrona, Jolanta Sawicka-Powierza, Jan Borys, Marcin Moniuszko, Jerzy A. Pałka, Ewa Jabłońska
J. Cancer 2018; 9(11): 1958-1965. doi:10.7150/jca.24238
[Abstract] [Full text] [PDF]

Research Paper
Trends and Outcomes of Sentinel Lymph Node Biopsy in Early-stage Vulvar Squamous Cell Carcinoma: A Population-based Study
Juan Zhou, Wen-Wen Zhang, Xue-Ting Chen, San-Gang Wu, Jia-Yuan Sun, Qiong-Hua Chen, Zhen-Yu He
J. Cancer 2018; 9(11): 1951-1957. doi:10.7150/jca.24044
[Abstract] [Full text] [PDF]

Research Paper
Analysis of Differential Expressions of Long Non-coding RNAs in Nasopharyngeal Carcinoma Using Next-generation Deep Sequencing
Xiao-xiao Li, Xu-jun liang, Liu-ying Zhou, Rui-jie Liu, Wu Bi, Sai Zhang, Shi-sheng Li, Wen-hui Yang, Zhu-chu Chen, Xin-ming Yang, Peng-fei Zhang
J. Cancer 2018; 9(11): 1943-1950. doi:10.7150/jca.23481
[Abstract] [Full text] [PDF]

Research Paper
MLH1 Promoter Methylation and Prediction/Prognosis of Gastric Cancer: A Systematic Review and Meta and Bioinformatic Analysis
Shixuan Shen, Xiaohui Chen, Hao Li, Liping Sun, Yuan Yuan
J. Cancer 2018; 9(11): 1932-1942. doi:10.7150/jca.23284
[Abstract] [Full text] [PDF]

Research Paper
The innovative regularity and role of p16 methylation in blood during HCC development
Cheng-Gang Jiang, Qun Chen, Lina Wu, Guang Wang, Jianzhong Ma
J. Cancer 2018; 9(11): 1925-1931. doi:10.7150/jca.23968
[Abstract] [Full text] [PDF]

Research Paper
Mycophenolate Mofetil induces c-Jun-N-terminal kinase expression in 22Rv1 cells: an impact on androgen receptor signaling
Ondrej Zenata, Zdenek Dvorak, Radim Vrzal
J. Cancer 2018; 9(11): 1915-1924. doi:10.7150/jca.23648
[Abstract] [Full text] [PDF]

Research Paper
Risk Factors of the Recurrences of Pancreatic Solid Pseudopapillary Tumors: A Systematic Review and Meta-analysis
Hao Gao, Yong Gao, Lingdi Yin, Guangfu Wang, Jishu Wei, Kuirong Jiang, Yi Miao
J. Cancer 2018; 9(11): 1905-1914. doi:10.7150/jca.24491
[Abstract] [Full text] [PDF]

Research Paper
Aberrant DNA methylation of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters in tumours and the surgical margins of patients with oral cavity cancer
Joanna Katarzyna Strzelczyk, Łukasz Krakowczyk, Aleksander Jerzy Owczarek
J. Cancer 2018; 9(11): 1896-1904. doi:10.7150/jca.24477
[Abstract] [Full text] [PDF]

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