Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Short Research Communication
A Single Nucleotide Polymorphism in HPGD Gene Is Associated with Prostate Cancer Risk
Xiaofei Qi, Yu Wang, Jianquan Hou, Yuhua Huang
J. Cancer 2017; 8(19): 4083-4086. doi:10.7150/jca.22025
[Abstract] [Full text] [PDF]

Research Paper
Programmed cell death ligand 1 protein levels predicted survival of non-small cell lung cancer
Shaohua Cui, Xinying Su, Lili Dong, Jialin Qian, Lin Ye, Tianwei Zhang, Haihua Fu, Hulin Han, Jiaqi Huang, Yihong Yao, Yi Gu, Liyan Jiang
J. Cancer 2017; 8(19): 4075-4082. doi:10.7150/jca.21415
[Abstract] [Full text] [PDF]

Research Paper
Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression
Florian Christoph Sigloch, Martina Tholen, Alejandro Gomez-Auli, Martin Lothar Biniossek, Thomas Reinheckel, Oliver Schilling
J. Cancer 2017; 8(19): 4065-4074. doi:10.7150/jca.21401
[Abstract] [Full text] [PDF]

Research Paper
Hazard rate of tumor recurrence over time in patients with colon cancer: implications for postoperative surveillance from three Japanese Foundation for Multidisciplinary Treatment of Cancer (JFMC) clinical trials
Hiromichi Maeda, Kosuke Kashiwabara, Toru Aoyama, Koji Oba, Michitaka Honda, Shuhei Mayanagi, Mitsuro Kanda, Chikuma Hamada, Sotaro Sadahiro, Junichi Sakamoto, Shigetoyo Saji, Takaki Yoshikawa
J. Cancer 2017; 8(19): 4057-4064. doi:10.7150/jca.21365
[Abstract] [Full text] [PDF]

Research Paper
The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1+/- lymphoblastoid cells
Emma C. Bourton, Pia-Amata Ahorner, Piers N. Plowman, Sheba Adam Zahir, Hussein Al-Ali, Christopher N. Parris
J. Cancer 2017; 8(19): 4048-4056. doi:10.7150/jca.21338
[Abstract] [Full text] [PDF]

Research Paper
Aberrant Expression of the Long Non-coding RNA GHRLOS and Its Prognostic Significance in Patients with Colorectal Cancer
Shuangjie Wu, Jun Liu, Xinhai Wang, Mengjun Li, Zongyou Chen, Yifan Tang
J. Cancer 2017; 8(19): 4040-4047. doi:10.7150/jca.21304
[Abstract] [Full text] [PDF]

Research Paper
UHRF1 is an Independent Prognostic Factor and a Potential Therapeutic Target of Esophageal Squamous Cell Carcinoma
Jiecheng Ye, Yong Zhang, Weiye Liang, Jianxian Huang, Lihui Wang, Xueyun Zhong
J. Cancer 2017; 8(19): 4027-4039. doi:10.7150/jca.21256
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling
Chen-min Sun, Jiang Geng, Yang Yan, Xudong Yao, Min Liu
J. Cancer 2017; 8(19): 4018-4026. doi:10.7150/jca.21226
[Abstract] [Full text] [PDF]

Research Paper
Heteroplasmy and Copy Number Variations of Mitochondria in 88 Hepatocellular Carcinoma Individuals
Weiyang Li, Yanwei Qi, Xiaofang Cui, Yuhui Sun, Qing Huo, Yan Yang, Xinyuan Wen, Meihua Tan, Shiyi Du, Huali Zhang, Meng Zhang, Chuanxin Liu, Qingsheng Kong
J. Cancer 2017; 8(19): 4011-4017. doi:10.7150/jca.21218
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Effect of Albumin-to-Globulin Ratio in Patients with solid tumors: A Systematic Review and Meta-analysis
Jiaxi He, Hui Pan, Wenhua Liang, Dakai Xiao, Xuewei Chen, Minzhang Guo, Jianxing He
J. Cancer 2017; 8(19): 4002-4010. doi:10.7150/jca.21141
[Abstract] [Full text] [PDF]

Research Paper
Albumin and Fibrinogen Combined Prognostic Grade Predicts Prognosis of Patients with Prostate Cancer
Yanqing Wang, Wei Chen, Chuanyi Hu, Xiaofei Wen, Jiahua Pan, Fan Xu, Yinjie Zhu, Xiaoguang Shao, Xun Shangguan, Liancheng Fan, Jianjun Sha, Zezhou Wang, Yong Cai, Qiang Liu, Baijun Dong, Wei Xue
J. Cancer 2017; 8(19): 3992-4001. doi:10.7150/jca.21061
[Abstract] [Full text] [PDF]

Research Paper
Post-Resection Exhaustion of Intra-Platelet Serotonin: Also an Indicator of Early Hepatocellular Carcinoma Recurrence?
Bibek Aryal, Toshiaki Shimizu, Jun Kadono, Akira Furoi, Teruo Komokata, Iwao Kitazono, Chihaya Koriyama, Munekazu Yamakuchi, Teruto Hashiguchi, Yutaka Imoto
J. Cancer 2017; 8(19): 3984-3991. doi:10.7150/jca.20971
[Abstract] [Full text] [PDF]

Research Paper
Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients
Marjut Niinivirta, Gunilla Enblad, Per-Henrik Edqvist, Fredrik Pontén, Anca Dragomir, Gustav J. Ullenhag
J. Cancer 2017; 8(19): 3975-3983. doi:10.7150/jca.20889
[Abstract] [Full text] [PDF]

Research Paper
Local surgical excision versus endoscopic resection for rectal carcinoid: A meta-analysis.
Qiaoqi Sui, Junzhong Lin, Jianhong Peng, Yujie Zhao, Yuxiang Deng, Zhizhong Pan
J. Cancer 2017; 8(19): 3969-3974. doi:10.7150/jca.21476
[Abstract] [Full text] [PDF]

Research Paper
Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential
Noa Kidan, Hazem Khamaisie, Nili Ruimi, Shay Roitman, Elizabeth Eshel, Najib Dally, Martin Ruthardt, Jamal Mahajna
J. Cancer 2017; 8(19): 3952-3968. doi:10.7150/jca.19633
[Abstract] [Full text] [PDF]

Research Paper
Fuzi Enhances Anti-Tumor Efficacy of Radiotherapy on Lung Cancer
Qi Zhang, Xue Chen, Youjun Luo, Huaping Ren, Tiankui Qiao
J. Cancer 2017; 8(19): 3945-3951. doi:10.7150/jca.22162
[Abstract] [Full text] [PDF]

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