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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
A Comparative Study of Genetic Profiles of Key Oncogenesis-Related Genes between Primary Lesions and Matched Lymph Nodes Metastasis in Lung Cancer
Yuqiao Chen, Beibei Mao, Xiong Peng, Yuan Zhou, Kun Xia, Hao Guo, Hong Jiang, Guo Wang, Wei Zhuang
J. Cancer 2019; 10(7): 1642-1650. doi:10.7150/jca.28266
[Abstract] [Full text] [PDF]

Research Paper
Deleted in Breast Cancer 1 as a Novel Prognostic Biomarker for Digestive System Cancers: A Meta-Analysis
Jingting Liu, Chunyan Meng, Changcan Li, Kaifeng Tang, Hongchao Tang, Jianhua Liao
J. Cancer 2019; 10(7): 1633-1641. doi:10.7150/jca.26935
[Abstract] [Full text] [PDF]

Review
The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor
Xu Wang, Zhi-Bin Wang, Chao Luo, Xiao-Yuan Mao, Xi Li, Ji-Ye Yin, Wei Zhang, Hong-Hao Zhou, Zhao-Qian Liu
J. Cancer 2019; 10(7): 1622-1632. doi:10.7150/jca.27780
[Abstract] [Full text] [PDF]

Research Paper
Estrogen Enhances Endometrial Cancer Cells Proliferation by Upregulation of Prohibitin
Bin Yang, Ruiying Chen, Xiaoyan Liang, Jiayan Shi, Xiaomei Wu, Zhenbo Zhang, Xiong Chen
J. Cancer 2019; 10(7): 1616-1621. doi:10.7150/jca.28218
[Abstract] [Full text] [PDF]

Research Paper
The Impact of Primary Tumor Sidedness on the Effect of Regorafenib in Refractory Metastatic Colorectal Cancer
Sang Eun Yoon, Su Jin Lee, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Seung Tae Kim
J. Cancer 2019; 10(7): 1611-1615. doi:10.7150/jca.29106
[Abstract] [Full text] [PDF]

Research Paper
c-Myb and its Effector COX-2 as an Indicator Associated with Prognosis and Therapeutic Outcome in Colorectal Cancer
Ruting Xie, Yongzhi Yang, Huizhen Zhang, Hu Liu, Jing Guo, Huanlong Qin, Yanlei Ma, Ajay Goel, Xinxiang Li, Qing Wei
J. Cancer 2019; 10(7): 1601-1610. doi:10.7150/jca.27261
[Abstract] [Full text] [PDF]

Research Paper
Association between Primary Tumor Location and Prognostic Survival in Synchronous Colorectal Liver Metastases after Surgical Treatment: A Retrospective Analysis of SEER Data
Zheng Wang, Xiangyu Wang, Ze Zhang, Xuan Wang, Mo Chen, Lu Lu, Wenwei Zhu, Jubo Zhang, Huliang Jia, Jinhong Chen
J. Cancer 2019; 10(7): 1593-1600. doi:10.7150/jca.29294
[Abstract] [Full text] [PDF]

Research Paper
Inhibition of RNA-Binding Protein Musashi-1 Suppresses Malignant Properties and Reverses Paclitaxel Resistance in Ovarian Carcinoma
Huaizeng Chen, Jia Liu, Hanzhi Wang, Qi Cheng, Caiyun Zhou, Xiaojing Chen, Feng Ye
J. Cancer 2019; 10(6): 1580-1592. doi:10.7150/jca.27352
[Abstract] [Full text] [PDF]

Review
The Carcinogenic Role of the Notch Signaling Pathway in the Development of Hepatocellular Carcinoma
Qinfeng Huang, Junhong Li, Jinghui Zheng, Ailing Wei
J. Cancer 2019; 10(6): 1570-1579. doi:10.7150/jca.26847
[Abstract] [Full text] [PDF]

Research Paper
Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers
Adenilson Leão Pereira, Leandro Magalhães, Fabiano Cordeiro Moreira, Laís Reis-das-Mercês, Amanda Ferreira Vidal, André Maurício Ribeiro-dos-Santos, Samia Demachki, Ana Karyssa Mendes Anaissi, Rommel Mario Rodríguez Burbano, Paulo Albuquerque, Sidney Emanuel Batista dos Santos, Paulo Pimentel de Assumpção, Ândrea Kely Campos Ribeiro-dos-Santos
J. Cancer 2019; 10(6): 1560-1569. doi:10.7150/jca.27457
[Abstract] [Full text] [PDF]

Research Paper
A Panel of 12-lncRNA Signature Predicts Survival of Pancreatic Adenocarcinoma
Huo Zhang, Mingxia Zhu, Yiping Du, Hui Zhang, Qing Zhang, Qingxie Liu, Zebo Huang, Lan Zhang, Hai Li, Lei Xu, Xin Zhou, Wei Zhu, Yongqian Shu, Ping Liu
J. Cancer 2019; 10(6): 1550-1559. doi:10.7150/jca.27823
[Abstract] [Full text] [PDF]

Research Paper
Genetic Association between Interleukin-4 Receptor Polymorphisms and Cancer Susceptibility: A Meta-Analysis Based on 53 Case-Control Studies
Yong Qi, Taofei Zeng, Song Fan, Li Zhang, Chaozhao Liang
J. Cancer 2019; 10(6): 1538-1549. doi:10.7150/jca.28137
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Value of XIAP Level in Patients with Various Cancers: A Systematic Review and Meta-Analysis
Xian Gao, Lei Zhang, Yong Wei, Yiqi Yang, Jun Li, Hao Wu, Yongmei Yin
J. Cancer 2019; 10(6): 1528-1537. doi:10.7150/jca.28229
[Abstract] [Full text] [PDF]

Research Paper
A 10-year Population-based Study of the Differences between NECs and Carcinomas of the Esophagus in Terms of Clinicopathology and Survival
Wen Cai, Weiting Ge, Ying Yuan, Kefeng Ding, Yinuo Tan, Dehao Wu, Hanguang Hu
J. Cancer 2019; 10(6): 1520-1527. doi:10.7150/jca.29483
[Abstract] [Full text] [PDF]

Research Paper
Nodal Promotes the Migration and Invasion of Bladder Cancer Cells via Regulation of Snail
Wenwei Chen, Tao Jiang, Houping Mao, Rui Gao, Xingjian Gao, Yanfeng He, Hua Zhang, Qin Chen
J. Cancer 2019; 10(6): 1511-1519. doi:10.7150/jca.29205
[Abstract] [Full text] [PDF]

Research Paper
Prognostic and Clinicopathological Significance of lncRNA MVIH in Cancer Patients
Yi Zhang, Shibu Lin, Xianjin Yang, Xu Zhang
J. Cancer 2019; 10(6): 1503-1510. doi:10.7150/jca.28541
[Abstract] [Full text] [PDF]

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