Editors-in-Chief:
Yan-Gao Man, MD., PhD., Co-Director, Laboratory of Proteomics and Protein Sciences, Veterans Affair Health System, Baltimore, MD, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Review
Break Breast Cancer Addiction by CRISPR/Cas9 Genome Editing
Haitao Yang, MariaLynn Jaeger, Averi Walker, Daniel Wei, Katie Leiker, Tao Weitao
J. Cancer 2018; 9(2): 219-231. doi:10.7150/jca.22554
[Abstract] [Full text] [PDF]

Research Paper
Investigating Esophageal Stent-Placement Outcomes in Patients with Inoperable Non-Cervical Esophageal Cancer
Mojgan Forootan, Morteza Tabatabaeefar, Nariman Mosaffa, Hormat Rahimzadeh Ashkalak, Mohammad Darvishi
J. Cancer 2018; 9(1): 213-218. doi:10.7150/jca.21854
[Abstract] [Full text] [PDF]

Research Paper
Activity and Immune Correlates of a Programmed Death-1 Blockade Antibody in the treatment of Refractory Solid Tumors
Chang Jiang, Xiuyu Cai, Hongxia Zhang, Xiaojun Xia, Bei Zhang, Liangping Xia
J. Cancer 2018; 9(1): 205-212. doi:10.7150/jca.21414
[Abstract] [Full text] [PDF]

Research Paper
KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck
Donghai Huang, Yuanzheng Qiu, Guo Li, Chao Liu, Li She, Diekuo Zhang, Xiyu Chen, Gangcai Zhu, Xin Zhang, Yongquan Tian, Yong Liu
J. Cancer 2018; 9(1): 198-204. doi:10.7150/jca.22145
[Abstract] [Full text] [PDF]

Research Paper
Albumin-to-Alkaline Phosphatase Ratio as an Independent Prognostic Factor for Overall Survival of Advanced Hepatocellular Carcinoma Patients without Receiving Standard Anti-Cancer Therapies
Xiurong Cai, Zhanhong Chen, Jie Chen, Xiaokun Ma, Mingjun Bai, Tiantian Wang, Xiangwei Chen, Donghao Wu, Li Wei, Xing Li, Qu Lin, Jingyun Wen, Danyun Ruan, Zexiao Lin, Min Dong, Xiangyuan Wu
J. Cancer 2018; 9(1): 189-197. doi:10.7150/jca.21799
[Abstract] [Full text] [PDF]

Research Paper
Systemic Inflammation Biomarkers Predict Survival in Patients of Early Stage Non-Small Cell Lung Cancer Treated With Stereotactic Ablative Radiotherapy - A Single Center Experience
Hui Luo, Hong Ge, Yingying Cui, Jiangong Zhang, Ruitai Fan, Anping Zheng, Xiaoli Zheng, Yanan Sun
J. Cancer 2018; 9(1): 182-188. doi:10.7150/jca.21703
[Abstract] [Full text] [PDF]

Research Paper
Exploration of the optimal treatment regimes for Esthesioneuroblastoma: a single center experience in China
Yujie Yuan, Jinning Ye, Huizhi Qiu, Shaoqing Niu, Bixiu Wen, Dongping Wang, Xinping Cao, Yufeng Ren
J. Cancer 2018; 9(1): 174-181. doi:10.7150/jca.21605
[Abstract] [Full text] [PDF]

Hypothesis
Hypothesis: Induction of biomarkers for detection of colonic neoplasms
Michael Bordonaro, Darina Lazarova
J. Cancer 2018; 9(1): 166-173. doi:10.7150/jca.22593
[Abstract] [Full text] [PDF]

Research Paper
KPNA2 promotes migration and invasion in epithelial ovarian cancer cells by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail activation
Long Huang, Yun Zhou, Xin-Ping Cao, Jia-Xin Lin, Lan Zhang, Shu-Ting Huang, Min Zheng
J. Cancer 2018; 9(1): 157-165. doi:10.7150/jca.20879
[Abstract] [Full text] [PDF]

Research Paper
Fibrinogen and C-reactive protein score is a prognostic index for patients with hepatocellular carcinoma undergoing curative resection: a prognostic nomogram study
Wei Gan, Yong Yi, Yipeng Fu, Jinlong Huang, Zhufeng Lu, Chuyu Jing, Jia Fan, Jian Zhou, Shuangjian Qiu
J. Cancer 2018; 9(1): 148-156. doi:10.7150/jca.22246
[Abstract] [Full text] [PDF]

Research Paper
Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review
Ying Chen, Hui Du, Lewen Bao, Wenxin Liu
J. Cancer 2018; 9(1): 141-147. doi:10.7150/jca.21187
[Abstract] [Full text] [PDF]

Research Paper
Increased expression of miR-155 and miR-222 is associated with lymph node positive status
Vladimir Chernyy, Vladimir Pustylnyak, Vadim Kozlov, Lyudmila Gulyaeva
J. Cancer 2018; 9(1): 135-140. doi:10.7150/jca.22181
[Abstract] [Full text] [PDF]

Research Paper
Classifying Non-Small Cell Lung Cancer by Status of Programmed Cell Death Ligand 1 and Tumor-Infiltrating Lymphocytes on Tumor Cells
Shaohua Cui, Lili Dong, Jialin Qian, Lin Ye, Liyan Jiang
J. Cancer 2018; 9(1): 129-134. doi:10.7150/jca.21842
[Abstract] [Full text] [PDF]

Research Paper
Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma
Weiwen Liu, Xian-lu Song, Shan-chao Zhao, Minyi He, Hai Wang, Ziyang Chen, Wei Xiang, Guozhong Yi, Songtao Qi, Yawei Liu
J. Cancer 2018; 9(1): 117-128. doi:10.7150/jca.21965
[Abstract] [Full text] [PDF]

Research Paper
Nuclear EGFR and Integrator/Super Elongation Complex concurrently binds to Immediate Early Genes for gene transactivation
Victor Chun-Lam Wong
J. Cancer 2018; 9(1): 108-116. doi:10.7150/jca.21925
[Abstract] [Full text] [PDF]

Review
NcRNAs and Cholangiocarcinoma
Zheng Wangyang, Ji Daolin, Xu yi, Li Zhenglong, Huang Lining, Cui Yunfu, Jiang Xingming
J. Cancer 2018; 9(1): 100-107. doi:10.7150/jca.21785
[Abstract] [Full text] [PDF]

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