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Deregulated Wnt signaling initiates most cases of colorectal cancer (CRC). Butyrate, a product of dietary fiber, hyperactivates Wnt signaling, resulting in induction of CRC cell apoptosis, which may in part explain the protective action of fiber. Nonsense mediated decay (NMD) of mRNAs containing premature stop codons (PTCs) affects tumorigenesis and upregulates Wnt signaling in human embryonic stem cells. . More ...
Yes Associated Protein 1 (YAP) and Transcriptional coactivator with PDZ-Binding Motif (TAZ) have gained notoriety for their ability to drive tumor initiation and progression in a wide variety of cancers, including melanoma. YAP and TAZ act as drivers of melanoma through its interaction with the TEAD family of transcription factors. Verteporfin is a benzoporphyrin derivative that is used clinically for photodynamic treatment of macular degeneration. . More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Review
MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment
Yanping Su, Ye Qiu, Zhidong Qiu, Peng Qu
J. Cancer 2019; 10(18): 4350-4356. doi:10.7150/jca.35205
[Abstract] [Full text] [PDF]

Research Paper
Detection of Plasma EGFR Mutations in NSCLC Patients with a Validated ddPCR Lung cfDNA Assay
Qiao-mei Guo, Lin Wang, Wen-jun Yu, Li-hua Qiao, Ming-na Zhao, Xiao-meng Hu, Ya-meng Sun, Sheng Ni, Yun-hua Xu, Jia-tao Lou
J. Cancer 2019; 10(18): 4341-4349. doi:10.7150/jca.31326
[Abstract] [Full text] [PDF]

Research Paper
Elevated MRE11 expression associated with progression and poor outcome in prostate cancer
Jun Wang, Wen-Hao Xu, Yu Wei, Yao Zhu, Xiao-Jian Qin, Hai-Liang Zhang, Ding-Wei Ye
J. Cancer 2019; 10(18): 4333-4340. doi:10.7150/jca.31454
[Abstract] [Full text] [PDF]

Research Paper
Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas
Qianqian Liu, Zhenzhen Li, Hao Shang, Qiaochu Zhang, Xiaomeng Wang, Yangyang Zhang, Yang Wang, Qianru Li, Chunsen Li, Chunxia Liu, Feng Li
J. Cancer 2019; 10(18): 4326-4332. doi:10.7150/jca.31730
[Abstract] [Full text] [PDF]

Review
Nutritional Therapy in Cancer Patients Receiving Chemoradiotherapy: Should We Need Stronger Recommendations to Act for Improving Outcomes?
Paolo Cotogni, Paolo Pedrazzoli, Elisabeth De Waele, Giuseppe Aprile, Gabriella Farina, Silvia Stragliotto, Francesco De Lorenzo, Riccardo Caccialanza
J. Cancer 2019; 10(18): 4318-4325. doi:10.7150/jca.31611
[Abstract] [Full text] [PDF]

Review
Prognostic role of pretreatment red blood cell distribution width in patients with cancer: A meta-analysis of 49 studies
Peng-Fei Wang, Si-Ying Song, Hang Guo, Ting-Jian Wang, Ning Liu, Chang-Xiang Yan
J. Cancer 2019; 10(18): 4305-4317. doi:10.7150/jca.31598
[Abstract] [Full text] [PDF]

Research Paper
BolA family member 2 enhances cell proliferation and predicts a poor prognosis in hepatocellular carcinoma with tumor hemorrhage
Jia Luo, Dong Wang, Sai Zhang, Kuan Hu, Haijun Wu, Juanni Li, Zhiming Wang, Yiming Tao
J. Cancer 2019; 10(18): 4293-4304. doi:10.7150/jca.31829
[Abstract] [Full text] [PDF]

Research Paper
High Expression Levels of ACTN1 and ACTN3 Indicate Unfavorable Prognosis in Acute Myeloid Leukemia
Xinrui Yang, Yifan Pang, Jilei Zhang, Jinlong Shi, Xinpei Zhang, Gaoqi Zhang, Siyuan Yang, Jing Wang, Kai Hu, Jijun Wang, Hongmei Jing, Xiaoyan Ke, Lin Fu
J. Cancer 2019; 10(18): 4286-4292. doi:10.7150/jca.31766
[Abstract] [Full text] [PDF]

Research Paper
GnRHa for Ovarian Protection and the Association between AMH and Ovarian Function during Adjuvant Chemotherapy for Breast Cancer
Ying Zhong, Yan Lin, Xinqi Cheng, Xin Huang, Yidong Zhou, Feng Mao, Yajing Wang, Jinghong Guan, Songjie Shen, Yali Xu, Li Peng, Yan li, Xi Cao, Qiang Sun
J. Cancer 2019; 10(18): 4278-4285. doi:10.7150/jca.31859
[Abstract] [Full text] [PDF]

Research Paper
High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer
Qi Wu, Xiaoqing Zhou, Peng Li, Wei Wang, Jun Wang, Mingyue Tan, Le Tao, Jianxin Qiu
J. Cancer 2019; 10(18): 4270-4277. doi:10.7150/jca.32656
[Abstract] [Full text] [PDF]

Research Paper
SphK1 functions downstream of IGF-1 to modulate IGF-1-induced EMT, migration and paclitaxel resistance of A549 cells: A preliminary in vitro study
Xingping Wu, Qibiao Wu, Xiqiao Zhou, Jianan Huang
J. Cancer 2019; 10(18): 4264-4269. doi:10.7150/jca.32646
[Abstract] [Full text] [PDF]

Research Paper
Treatment of cancer cells with chemotherapeutic drugs results in profound changes in expression of genes encoding aldehyde-metabolizing enzymes
Olga L. Zinovieva, Evgeniya N. Grineva, George S. Krasnov, Dmitry S. Karpov, Andrei O. Zheltukhin, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Tamara D. Mashkova, Nikolai A. Lisitsyn
J. Cancer 2019; 10(18): 4256-4263. doi:10.7150/jca.32608
[Abstract] [Full text] [PDF]

Research Paper
Dihydromyricetin induced lncRNA MALAT1-TFEB-dependent autophagic cell death in cutaneous squamous cell carcinoma
Miduo Tan, Bin Jiang, Haihua Wang, Wei Ouyang, Xiang Chen, Taoli Wang, Dan Dong, Shun Yi, Jiansheng Yi, Yan Huang, Manling Tang, Yan Xiao, Zuiming Jiang, Wei Zhou
J. Cancer 2019; 10(18): 4245-4255. doi:10.7150/jca.32807
[Abstract] [Full text] [PDF]

Research Paper
Impact of gender as a prognostic factor in HBV-related Hepatocellular Carcinoma: the survival strength of female patients in BCLC stage 0-B
Lihua Yu, Xiaoli Liu, Xinhui Wang, Zhibo Dang, Yuyong Jiang, Xianbo Wang, Zhiyun Yang
J. Cancer 2019; 10(18): 4237-4244. doi:10.7150/jca.33430
[Abstract] [Full text] [PDF]

Research Paper
Comparative study of large cell neuroendocrine carcinoma and small cell lung carcinoma in high-grade neuroendocrine tumors of the lung: a large population-based study
Jian Wang, Ling Ye, Hui Cai, Meiling Jin
J. Cancer 2019; 10(18): 4226-4236. doi:10.7150/jca.33367
[Abstract] [Full text] [PDF]

Research Paper
Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging
Lu Zhang, Hongyu Zhou, Dongsheng Gu, Jie Tian, Bin Zhang, Di Dong, Xiaokai Mo, Jing Liu, Xiaoning Luo, Shufang Pei, Yuhao Dong, Wenhui Huang, Qiuyin Chen, Changhong Liang, Zhouyang Lian, Shuixing Zhang
J. Cancer 2019; 10(18): 4217-4225. doi:10.7150/jca.33345
[Abstract] [Full text] [PDF]

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