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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Association of endothelial nitric oxide synthase (eNOS) polymorphisms with EGFR-mutated lung adenocarcinoma in Taiwan
Chun-Yao Huang, Ming-Ju Hsieh, Wen-Jun Wu, Whei-Ling Chiang, Tu-Chen Liu, Shun-Fa Yang, Thomas Chang-Yao Tsao
J. Cancer 2018; 9(14): 2518-2524. doi:10.7150/jca.25824
[Abstract] [Full text] [PDF]

Review
Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer
Xinqiang Wu, Yuanbing Wu, Liangmei He, Longhuo Wu, Xiangcai Wang, Zhiping Liu
J. Cancer 2018; 9(14): 2510-2517. doi:10.7150/jca.25324
[Abstract] [Full text] [PDF]

Research Paper
The significant prognostic value of ZEB1-AS1 up-regulation in patients with cancer.
Ying Ni, Jian Fang, Linqi Zhu, Hui Jiang, Yun Liu, Renjie Miao, Chen Shao, Shihe Shao
J. Cancer 2018; 9(14): 2502-2509. doi:10.7150/jca.25264
[Abstract] [Full text] [PDF]

Research Paper
MCT1 regulates aggressive and metabolic phenotypes in bladder cancer
Guiming Zhang, Yongjian Zhang, Dahai Dong, Fangming Wang, Xiaocheng Ma, Fengju Guan, Lijiang Sun
J. Cancer 2018; 9(14): 2492-2501. doi:10.7150/jca.25257
[Abstract] [Full text] [PDF]

Research Paper
Cry 1 Regulates the Clock Gene Network and Promotes Proliferation and Migration Via the Akt/P53/P21 Pathway in Human Osteosarcoma Cells
Lei Zhou, Yueming Yu, Shiwei Sun, Tieqi Zhang, Minghai Wang
J. Cancer 2018; 9(14): 2480-2491. doi:10.7150/jca.25213
[Abstract] [Full text] [PDF]

Research Paper
HE4 and eIF3a Expression Correlates with Surgical Outcome and Overall Survival in Ovarian Cancer Patients with Secondary Cytoreduction
Chen-Hui Luo, Min Zhao, Xiao-Yan Chen, Shohreh Shahabi, Wenan Qiang, Liang Zeng, Jing Wang, Hong-Hao Zhou
J. Cancer 2018; 9(14): 2472-2479. doi:10.7150/jca.25184
[Abstract] [Full text] [PDF]

Research Paper
Impact of Prognostic Nutritional Index on Overall Survival for Patients with Metastatic Urothelial Carcinoma
Meng-Che Hsieh, Kun-Ming Rau, Po-Hui Chiang, Ming-Tse Sung, Jui Lan, Hao-Lun Luo, Chun-Chieh Huang, Cheng-Hua Huang, Harvey Yu-Li Su
J. Cancer 2018; 9(14): 2466-2471. doi:10.7150/jca.25061
[Abstract] [Full text] [PDF]

Research Paper
miR-423 rs6505162 C>A polymorphism contributes to decreased Wilms tumor risk
Wen Fu, Li Li, Si-Wei Xiong, Tiesong Zhang, Wei Jia, Jinhong Zhu, Zhang Zhao, Huimin Xia, Jing He, Guo-Chang Liu
J. Cancer 2018; 9(14): 2460-2465. doi:10.7150/jca.24916
[Abstract] [Full text] [PDF]

Research Paper
Effect of FAM196B in human lung adenocarcinoma
Yu Feng, Xing Tong, Biao Zhang, Guocai Mao, Haitao Huang, Haitao Ma
J. Cancer 2018; 9(14): 2451-2459. doi:10.7150/jca.24907
[Abstract] [Full text] [PDF]

Research Paper
Dosimetric Effects of Head and Neck Immobilization Devices on Multi-field Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma
Li Chen, Ying-Lin Peng, Shi-Yong Gu, Hui Shen, Dan-Dan Zhang, Wen-Zhao Sun, Jian-Hua Wu, Xiao-Wu Deng
J. Cancer 2018; 9(14): 2443-2450. doi:10.7150/jca.24887
[Abstract] [Full text] [PDF]

Research Paper
LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer
Qinfeng Zhou, Xinyi Tang, Xinyu Tian, Jie Tian, Yue Zhang, Jie Ma, Huaxi Xu, Shengjun Wang
J. Cancer 2018; 9(14): 2436-2442. doi:10.7150/jca.24796
[Abstract] [Full text] [PDF]

Research Paper
Additional lymphadenectomy might not improve survival of patients with resectable metastatic colorectal adenocarcinoma of T4 stage, proximal location, poor/undifferentiation, or N3/N4 stages: a large population-based study.
Yang-Yang Zhou, Qing-Wei Zhang, Jian Huang, Xia-Lin Yan, Chao Chen, Fan-Fan Xu, Xiao-Jing Du, Rong Jin
J. Cancer 2018; 9(14): 2428-2435. doi:10.7150/jca.24675
[Abstract] [Full text] [PDF]

Research Paper
ELTD1 Function in Hepatocellular Carcinoma is Carcinoma-Associated Fibroblast-Dependent
Anna Kan, Yong Le, Yong-fa Zhang, Fang-ting Duan, Xiao-ping Zhong, Liang-he Lu, Yi-hong Ling, Rong-ping Guo
J. Cancer 2018; 9(14): 2415-2427. doi:10.7150/jca.24406
[Abstract] [Full text] [PDF]

Research Paper
Comparison of vascularity observed using contrast-enhanced 3D ultrasonography and pathological changes in patients with hepatocellular carcinoma after sorafenib treatment
Hiroyuki Fukuda, Kazushi Numata, Koji Hara, Akito Nozaki, Masaaki Kondo, Makoto Chuma, Masayuki Nakano, Akinori Nozawa, Shin Maeda, Katsuaki Tanaka
J. Cancer 2018; 9(13): 2408-2414. doi:10.7150/jca.24236
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Values of CCNE1 Amplification and Overexpression in Cancer Patients: A Systematic Review and Meta-analysis
Haiyue Zhao, Junling Wang, Yong Zhang, Ming Yuan, Shuangxiang Yang, Lisong Li, Huilin Yang
J. Cancer 2018; 9(13): 2397-2407. doi:10.7150/jca.24179
[Abstract] [Full text] [PDF]

Research Paper
PDE4a predicts poor prognosis and promotes metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma
Yanghong Peng, Yijun Li, Yu Tian, Guokun Ao
J. Cancer 2018; 9(13): 2389-2396. doi:10.7150/jca.24079
[Abstract] [Full text] [PDF]

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