Editors-in-Chief:
Yan-Gao Man, MD., PhD., Director for Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA
Naoto T. Ueno, MD., PhD., Professor of Medicine, University of Texas MD Anderson Cancer Center
Editors-in-Chief Profile
  • new Impact factor is 2.639 according to the 2014 release of Journal Citation Reports.
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Top cited papers:

Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
MicroRNAs are small non-coding RNA molecules that have been shown to regulate the expression of genes linked to cancer. The relevance of microRNAs in the development, progression and prognosis of prostate cancer is not fully understood. It is also possible that these specific molecules may assist in the recognition of aggressive tumors and the development of new molecular targets. Our study investigated the importance of several microRNAs in cases of prostate cancer from 37 patients that were manually microdissected to obtain pure populations of tumor cells, normal epithelium and adjacent stroma. MicroRNA was extracted for PCR array profiling. Differentially expressed miRNAs for each case were used to compare tumor vs. normal epithelium and tumor-adjacent stroma samples... More ...
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Journal of Cancer is a peer-reviewed journal publishing papers of high quality in all areas of cancer related fields, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.

Latest papers:

Research Paper
Longitudinal FDG-PET Revealed Regional Functional Heterogeneity of Bone Marrow, Site-Dependent Response to Treatment and Correlation with Hematological Parameters
Masashi Yagi, Jerry Froelich, Luke Arentsen, Ryan Shanley, Rahel Ghebre, Douglas Yee, Susanta Hui
J. Cancer 2015; 6(6): 531-537. doi:10.7150/jca.11348
[Abstract] [Full text] [PDF]

Research Paper
Complement Receptor 1 Genetic Variants Contribute to the Susceptibility to Gastric Cancer in Chinese Population
Lina Zhao, Zhi Zhang, Jia Lin, Lei Cao, Bing He, Sugui Han, Xuemei Zhang
J. Cancer 2015; 6(6): 525-530. doi:10.7150/jca.10749
[Abstract] [Full text] [PDF]

Research Paper
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C
Huilei Zhou, Lin Wang, Juxiang Huang, Minghu Jiang, Xiaoyu Zhang, Liyuan Zhang, Yangming Wang, Zhenfu Jiang, Zhongjie Zhang
J. Cancer 2015; 6(6): 519-524. doi:10.7150/jca.11404
[Abstract] [Full text] [PDF]

Research Paper
TGF-β Induces Degradation of PTHrP through Ubiquitin-Proteasome System in Hepatocellular Carcinoma
Hao Li, Guangchun He, Hui Yao, Liujiang Song, Liang Zeng, Xiaoning Peng, Thomas J. Rosol, Xiyun Deng
J. Cancer 2015; 6(6): 511-518. doi:10.7150/jca.10830
[Abstract] [Full text] [PDF]

Research Paper
Significant Prognostic Impact of Chemoradiotherapy-Induced Hemoglobin Decrease on Treatment Outcomes of Nasopharyngeal Carcinoma
Xue-Xia Liang, Qun Li, Zhen Su, Xiao-Wen Lan, Pu-Yun Ouyang, Yan-Ping Mao, Ding-Bo Shi, Wu-Guo Deng, Zhi-Bin Cheng, Si-Yang Wang, Fang-Yun Xie
J. Cancer 2015; 6(6): 502-510. doi:10.7150/jca.11403
[Abstract] [Full text] [PDF]

Research Paper
Reconstitution of the ERG Gene Expression Network Reveals New Biomarkers and Therapeutic Targets in ERG Positive Prostate Tumors
Alexey Dubovenko, Tatiana Serebryiskaya, Yuri Nikolsky, Tatiana Nikolskaya, Ally Perlina, Lellean JeBailey, Svetlana Bureeva, Shilpa Katta, Shiv Srivastava, Albert Dobi, Tatiana Khasanova
J. Cancer 2015; 6(6): 490-501. doi:10.7150/jca.8213
[Abstract] [Full text] [PDF]

Research Paper
Hyponatremia in Hepatocellular Carcinoma Complicating with Cirrhosis
Hiroki Nishikawa, Ryuichi Kita, Toru Kimura, Yoshiaki Ohara, Azusa Sakamoto, Sumio Saito, Norihiro Nishijima, Akihiro Nasu, Hideyuki Komekado, Yukio Osaki
J. Cancer 2015; 6(5): 482-489. doi:10.7150/jca.11665
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Association of BTBD7 with Metastasis and Poor Prognosis in Non-Small-Cell Lung Cancer Patients
Fan-Yan Luo, Zi-Hou Liu, Qin-Hua Hu, Guo-Qiang Lin, Can-E Tang, Wei-Xing Zhang, Wei Zhuang
J. Cancer 2015; 6(5): 477-481. doi:10.7150/jca.11715
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Role of Mitochondrial Network Stabilisation by a Human Small Heat Shock Protein in Tumour Malignancy
Zsuzsanna Turi, Eniko Hocsak, Boglarka Racz, Aliz Szabo, Andras Balogh, Balazs Sumegi, Ferenc Gallyas
J. Cancer 2015; 6(5): 470-476. doi:10.7150/jca.11494
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Risk Factors for Discontinuation of S-1 Adjuvant Chemotherapy for Gastric Cancer
Hitoshi Kawazoe, Maya Shimasaki, Masaki Ueno, Satomi Sumikawa, Shingo Takatori, Hiroyuki Namba, Motohira Yoshida, Koichi Sato, Yoh Kojima, Yuji Watanabe, Toshihide Moriguchi, Akihiro Tanaka, Hiroaki Araki
J. Cancer 2015; 6(5): 464-469. doi:10.7150/jca.11189
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Commentary
Hypotheses of Cancer Weakening and Origin
John Cheung Yuen CHAN
J. Cancer 2015; 6(5): 457-463. doi:10.7150/jca.10911
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Anti-Gastrins Antiserum Combined with Lowered Dosage Cytotoxic Drugs to Inhibit the Growth of Human Gastric Cancer SGC7901 Cells in Nude Mice
Qing He, Hua Gao, Meng Gao, Shengmei Qi, Yingqi Zhang, Junzhi Wang
J. Cancer 2015; 6(5): 448-456. doi:10.7150/jca.11400
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Problems of Long Survival Following Surgery in Patients with NonBNonC-HCC: Comparison with HBV and HCV Related-HCC
Kiyokazu Hiwatashi, Shinichi Ueno, Masahiko Sakoda, Satoshi Iino, Koji Minami, Yoichi Yamasaki, Keishi Okubo, Masahiro Noda, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Hiroyuki Shinchi, Shoji Natsugoe
J. Cancer 2015; 6(5): 438-447. doi:10.7150/jca.10398
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Effects of Hypoxia, Surrounding Fibroblasts, and p16 Expression on Breast Cancer Cell Migration and Invasion
Jun Zhang, Liyuan Li, Yi Lu
J. Cancer 2015; 6(5): 430-437. doi:10.7150/jca.11353
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer
Wenzhi Li, Fengfu Guo, Meng Gu, Guangjian Wang, Xiangfei He, Juan Zhou, Yubing Peng, Zhong Wang, Xiang Wang
J. Cancer 2015; 6(5): 420-429. doi:10.7150/jca.11228
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Prognostic Significance of Lymphovascular Space Invasion in Epithelial Ovarian Cancer
Ming Chen, Ying Jin, Yalan Bi, Yan Li, Ying Shan, Lingya Pan
J. Cancer 2015; 6(5): 412-419. doi:10.7150/jca.11242
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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