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Inhaled therapy for lung cancer is a local form of treatment. Currently inhaled non-specific cytotoxic agents have been evaluated as a future treatment for local disease control and distant metastasis control. There are few information regarding the influence of local transporters and gene expression of the respiratory epithelium to the absorption of administered drugs. In the current work we used adenoviral-type 5(dE1/E3) (Cytomegalovirus promoter) with human ABCA10 transgene (Ad-h-ABCA10) purchased from Vector Labs® in order to investigate whether gene therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin. More ...
Background: Expression of programmed death ligand (PD-L1/B7-H1/CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. Drugs blocking PD-L1 or its receptor are in clinical development and early data suggests that tumor PD-L1 expression may predict response. Patients and Methods: A tissue microarray (TMA) consisting of four biopsy cores from 34 matched pairs of nephrectomy and metastatic sites of clear cell RCC was used to assess PD-L1 expression by quantitative immunofluorescence. Assessment of intra- and inter-tumor heterogeneity and primary and metastatic tumor expression was performed using a method of Automated Quantitative Analysis (AQUA). More ...
Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer. Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. More ...
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Research Paper
Serum level of co-expressed hub miRNAs as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma
Qiang Su, Emily C Zhu, Yao-long Qu, Di-ya Wang, Wei-wei Qu, Chen-guang Zhang, Ting Wu, Zu-hua Gao
J. Cancer 2018; 9(21): 3991-3999. doi:10.7150/jca.27697
[Abstract] [Full text] [PDF]

Research Paper
A nomogram to predict long-time survival for patients with M1 diseases of esophageal cancer
Mina Liu, Changlu Wang, Lanting Gao, Changxing Lv, Xuwei Cai
J. Cancer 2018; 9(21): 3986-3990. doi:10.7150/jca.27579
[Abstract] [Full text] [PDF]

Research Paper
Tumor deposit is an independent prognostic indicator in patients who underwent radical resection for colorectal cancer
Shiva Basnet, Qi-feng Lou, Nan Liu, Ramesh Rana, Abilasha Shah, Mamata Khadka, Hemanshu Warrier, Shushil Sigdel, Sunil Dhakal, Anita Devkota, Roshan Mishra, Ganga Sapkota, Liang Zheng, Hai-yan Ge
J. Cancer 2018; 9(21): 3979-3985. doi:10.7150/jca.27475
[Abstract] [Full text] [PDF]

Research Paper
Multiple Machine Learnings Revealed Similar Predictive Accuracy for Prognosis of PNETs from the Surveillance, Epidemiology, and End Result Database
Yiyan Song, Shaowei Gao, Wulin Tan, Zeting Qiu, Huaqiang Zhou, Yue Zhao
J. Cancer 2018; 9(21): 3971-3978. doi:10.7150/jca.26649
[Abstract] [Full text] [PDF]

Research Paper
Huaier Augmented the Chemotherapeutic Sensitivity of Oxaliplatin via Downregulation of YAP in Hepatocellular Carcinoma
Yuquan Tao, Liang Shan, Xin Xu, Hongyuan Jiang, Rui Chen, Zijun Qian, Zongguo Yang, Bin Liang, Haiyin Zhen, Feng Cai, Yongchun Yu, Lifang Ma
J. Cancer 2018; 9(21): 3962-3970. doi:10.7150/jca.25909
[Abstract] [Full text] [PDF]

Research Paper
CDK5 Functions as a Tumor Promoter in Human Lung Cancer
Jie Zeng, Shuanshuan Xie, Yang Liu, Changxing Shen, Xiaolian Song, Guo-Lei Zhou, Changhui Wang
J. Cancer 2018; 9(21): 3950-3961. doi:10.7150/jca.25967
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of Peroxiredoxin 6 (PRDX6) Promotes the Aggressive Phenotypes of Esophageal Squamous Cell Carcinoma
Yan He, Wanglei Xu, Yuji Xiao, Lu Pan, Guangxia Chen, Yiting Tang, Jundong Zhou, Jinchang Wu, Wei Zhu, Shuyu Zhang, Jianping Cao
J. Cancer 2018; 9(21): 3939-3949. doi:10.7150/jca.26041
[Abstract] [Full text] [PDF]

Research Paper
FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer
Yang Lan, Xuewei Xiao, Yu Luo, Zhengchi He, Xu Song
J. Cancer 2018; 9(21): 3929-3938. doi:10.7150/jca.26073
[Abstract] [Full text] [PDF]

Research Paper
A Prognostic Nomogram for Cervical Cancer after Surgery from SEER Database
Ce Wang, Chunyan Yang, Wenjie Wang, Bairong Xia, Kang Li, Fengyu Sun, Yan Hou
J. Cancer 2018; 9(21): 3923-3928. doi:10.7150/jca.26220
[Abstract] [Full text] [PDF]

Research Paper
Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis
Yaoyi Xiong, Lushun Yuan, Liang Chen, Yuan Zhu, Shanshan Zhang, Xuefeng Liu, Yu Xiao, Xinghuan Wang
J. Cancer 2018; 9(21): 3912-3922. doi:10.7150/jca.25900
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Value of Plasma Fibrinogen in Lung Cancer Patients: A Meta-Analysis
Hai Zhong, Yingying Qian, Surong Fang, Ying Wang, Yun Tang, Wei Gu
J. Cancer 2018; 9(21): 3904-3911. doi:10.7150/jca.26360
[Abstract] [Full text] [PDF]

Research Paper
The Role of CXCL12 Axis in Lung Metastasis of Colorectal Cancer
Meng Wang, Xuyang Yang, Mingtian Wei, Ziqiang Wang
J. Cancer 2018; 9(21): 3898-3903. doi:10.7150/jca.26383
[Abstract] [Full text] [PDF]

Review
Classification of Solitary Plasmacytoma, Is it more Intricate than Presently Suggested? A Commentary
Nissim Ohana, Ory Rouvio, Karen Nalbandyan, Dimitri Sheinis, Daniel Benharroch
J. Cancer 2018; 9(21): 3894-3897. doi:10.7150/jca.26854
[Abstract] [Full text] [PDF]

Research Paper
Impact of the Receptor for Advanced Glycation End Products Genetic Polymorphisms on the Progression in Uterine Cervical Cancer
Chung-Yuan Lee, Soo-Cheen Ng, Yi-Hsuan Hsiao, Shun-Fa Yang, Chun-Fang Hsu, Po-Hui Wang
J. Cancer 2018; 9(21): 3886-3893. doi:10.7150/jca.27960
[Abstract] [Full text] [PDF]

Research Paper
Ethanol Enhances Estrogen Mediated Angiogenesis in Breast Cancer
Rachana Maniyar, Sanjukta Chakraborty, Robert Suriano
J. Cancer 2018; 9(21): 3874-3885. doi:10.7150/jca.25581
[Abstract] [Full text] [PDF]

Review
microRNA biomarkers in colorectal cancer liver metastasis
Shulin Huang, Xiaohui Tan, Zhongcheng Huang, Zihua Chen, Paul Lin, Sidney W. Fu
J. Cancer 2018; 9(21): 3867-3873. doi:10.7150/jca.28588
[Abstract] [Full text] [PDF]

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