J Cancer 2012; 3:96-99. doi:10.7150/jca.3770

Case Report

Prostatic Metastasis of Pulmonary Large Cell Neuroendocrine Carcinoma

Kumi Shimizu1, Taichiro Goto2✉, Arafumi Maeshima3, Yoshitaka Oyamada1, Ryoichi Kato2

1. Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan;
2. Department of General Thoracic Surgery, National Hospital Organization Tokyo Medical Center, Tokyo, Japan;
3. Department of Pathology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

Abstract

Lung cancer metastases to the prostate are uncommon, and are usually found incidentally during autopsy. This case report describes a 77-year-old man with a large cell neuroendocrine carcinoma (LCNEC) of the lung and metastases from this primary cancer in the prostate. During the follow-up after the chemotherapy performed for pulmonary LCNEC, pelvic computed tomography revealed a prostatic tumor and prostatic needle biopsy was performed. Histologically, the tumor was identified as LCNEC, forming a tissue architecture closely resembling the previously diagnosed lung cancer. The tumor cells were immunohistochemically positive for thyroid transcription factor-1. These findings led to a diagnosis of prostatic metastasis of pulmonary LCNEC.

Keywords: prostatic metastasis, lung cancer, large cell neuroendocrine carcinoma, immunohistochemistry.

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How to cite this article:
Shimizu K, Goto T, Maeshima A, Oyamada Y, Kato R. Prostatic Metastasis of Pulmonary Large Cell Neuroendocrine Carcinoma. J Cancer 2012; 3:96-99. doi:10.7150/jca.3770. Available from http://www.jcancer.org/v03p0096.htm