J Cancer 2012; 3:303-309. doi:10.7150/jca.4179

Mini-Review/Case Report

Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New Findings

Aitao Guo, Aijun Liu, Lixin Wei, Xin Song

Department of Pathology, the Chinese PLA General Hospital, Beijing 100853, China.

Abstract

Malignant peripheral nerve sheath tumors (MPNST) represent a group of highly heterogeneous human malignancies often with multiple histological origins, divergent differentiation patterns, and diverse immunohistochemical presentations. The differential diagnosis of MPNST from other spindle cell neoplasms poses great challenges for pathologists. This report provides a mini-review of these unique features associated with MPNST and also presents the first cases of MPNST with six differentiation patterns.

Keywords: Malignant peripheral nerve sheath tumor, Liposarcomatous, Glandular, Fibrohistiocytoid, Neuroendocrine differentiation, Cartilage, Triton tumor, Gangliocyte.

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How to cite this article:
Guo A, Liu A, Wei L, Song X. Malignant Peripheral Nerve Sheath Tumors: Differentiation Patterns and Immunohistochemical Features - A Mini-Review and Our New Findings. J Cancer 2012; 3:303-309. doi:10.7150/jca.4179. Available from http://www.jcancer.org/v03p0303.htm