Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions

Drevelegas, Konstantinos; Nikiforaki, Katerina; Constantinides, Manolis; Papanikolaou, Nickolas; Papalavrentios, Lavrentios; Stoikou, Ioanna; Zarogoulidis, Paul; Pitsiou, Georgia; Pataka, Athanasia; Organtzis, John; Papadaki, Eleni; Porpodis, Konstantinos; Kougioumtzi, Ioanna; Kioumis, Ioannis; Kouskouras, Constantinos; Akriviadis, Evaggelos; Drevelegas, Antonios

doi:10.7150/jca.14197



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2016; 7(6):730-735. doi:10.7150/jca.14197 This issue Cite

Research Paper

Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions

Konstantinos Drevelegas¹, Katerina Nikiforaki², Manolis Constantinides¹, Nickolas Papanikolaou², Lavrentios Papalavrentios³, Ioanna Stoikou⁵, Paul Zarogoulidis^6✉, Georgia Pitsiou⁶, Athanasia Pataka⁶, John Organtzis⁶, Eleni Papadaki⁶, Konstantinos Porpodis⁶, Ioanna Kougioumtzi⁷, Ioannis Kioumis⁶, Constantinos Kouskouras⁴, Evaggelos Akriviadis³, Antonios Drevelegas¹

1. Department of Radiology, Interbalkan Medical Centre, Thessaloniki, Greece;
2. Research & Development, N.Papanikolaou & Associates LLC, Crete, Greece;
3. Department of Internal Medicine-Gastroenterology, Interbalkan Medical Centre, Thessaloniki, Greece;
4. Department of Radiology, Ahepa University Hospital, Thessaloniki, Greece;
5. Department of Microbiolgy, George Gennimatas Hospital, Thessaloniki, Greece;
6. Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece;
7. Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece.

Citation:

Drevelegas K, Nikiforaki K, Constantinides M, Papanikolaou N, Papalavrentios L, Stoikou I, Zarogoulidis P, Pitsiou G, Pataka A, Organtzis J, Papadaki E, Porpodis K, Kougioumtzi I, Kioumis I, Kouskouras C, Akriviadis E, Drevelegas A. Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions. J Cancer 2016; 7(6):730-735. doi:10.7150/jca.14197. https://www.jcancer.org/v07p0730.htm

Other styles

Abstract

Purpose: Diffusion Weighted Imaging is an established diagnostic tool for accurate differential diagnosis between benign and malignant liver lesions. The aim of our study was to evaluate the role of Histogram Analysis of ADC quantification in determining the histological diagnosis as well as the grade of malignant liver tumours. To our knowledge, there is no study evaluating the role of Histogram Analysis of ADC quantification in determining the histological diagnosis as well as the grade of malignant liver tumours.

Methods: During five years, 115 patients with known liver lesions underwent Diffusion Weighted Imaging in 3Tesla MR scanner prior to core needle biopsy. Histogram analyses of ADC in regions of interest were drawn and were correlated with biopsy histological diagnosis and grading.

Results: Histogram analysis of ADC values shows that 5th and 30th percentile parameters have statistically significant potency of discrimination between primary and secondary lesions groups (p values 0.0036 and 0.0125 respectively). Skewness of the histogram can help discriminate between good and poor differentiated (p value 0.17). Discrimination between primary malignancy site in metastases failed for the present number of patients in each subgroup.

Conclusion: Statistical parameters reflecting the shape of the left side of the ADC histogram can be useful for discriminating between primary and secondary lesions and also between well differentiated versus moderate or poor. For the secondary malignancies, they failed to predict the original site of tumour.

Keywords: Diffusion Weighted Imaging, histogram analysis, liver lesions, biopsy.

Citation styles

APA

Drevelegas, K., Nikiforaki, K., Constantinides, M., Papanikolaou, N., Papalavrentios, L., Stoikou, I., Zarogoulidis, P., Pitsiou, G., Pataka, A., Organtzis, J., Papadaki, E., Porpodis, K., Kougioumtzi, I., Kioumis, I., Kouskouras, C., Akriviadis, E., Drevelegas, A. (2016). Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions. Journal of Cancer, 7(6), 730-735. https://doi.org/10.7150/jca.14197.

ACS

Drevelegas, K.; Nikiforaki, K.; Constantinides, M.; Papanikolaou, N.; Papalavrentios, L.; Stoikou, I.; Zarogoulidis, P.; Pitsiou, G.; Pataka, A.; Organtzis, J.; Papadaki, E.; Porpodis, K.; Kougioumtzi, I.; Kioumis, I.; Kouskouras, C.; Akriviadis, E.; Drevelegas, A. Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions. J. Cancer 2016, 7 (6), 730-735. DOI: 10.7150/jca.14197.

NLM

CSE

Drevelegas K, Nikiforaki K, Constantinides M, Papanikolaou N, Papalavrentios L, Stoikou I, Zarogoulidis P, Pitsiou G, Pataka A, Organtzis J, Papadaki E, Porpodis K, Kougioumtzi I, Kioumis I, Kouskouras C, Akriviadis E, Drevelegas A. 2016. Apparent Diffusion Coefficient Quantification in Determining the Histological Diagnosis of Malignant Liver Lesions. J Cancer. 7(6):730-735.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.