J Cancer 2017; 8(4):531-536. doi:10.7150/jca.17519

Research Paper

Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population

Bang-Shun He1*, Hui-Ling Sun1*, Tao Xu1, Yu-Qin Pan1, Kang Lin1, Tian-Yi Gao2, Zhen-Yu Zhang3, Shu-Kui Wang1✉

1. General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;
2. Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;
3. Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
*These authors contributed equally to this work.

Abstract

Background: Genome-wide association studies have identified that polymorphisms in 8q24 confer susceptibility to gastric cancer. Polymorphisms in the lncRNA PRNCR1, PCAT1, and CCAT2 transcribed from the 8q24 locus have a potential risk for gastric cancer.

Methods: To evaluate whether there is such an association in Chinese population, a case-control study enrolled 494 patients and 494 healthy controls was carried out. Sequenom MassARRAY platform was used for genotyping.

Results: This study showed that rs16901946 G allele was associated with increased risk of gastric cancer (AG: adjusted OR = 1.33, 95% CI =1.02-1.73, p=0.033; GG: adjusted OR = 2.07; 95% CI = 1.11-3.86, p=0.023, AG/GG: adjusted OR = 1.39, 95% CI = 1.08-1.1.79, p=0.011; additive model: adjusted OR = 1.37; 95% CI = 1.10-1.70, p=0.004). Stratified analysis revealed that the increased risk was more evident in the cohort of younger subjects (adjusted OR = 1.84, 95% CI = 1.18-2.87, p=0.007), males (adjusted OR = 1.55, 95% CI = 1.15-2.08, p=0.004), positive Helicobacter pylori infection (adjusted OR = 1.44, 95% CI = 1.02-2.03, p=0.041), gastric cardia adenocarcinoma (adjusted OR = 1.61, 95% CI = 1.10-2.35, p=0.014), and tumor stage T1-T2 (adjusted OR = 1.58, 95% CI = 1.10-2.28, p=0.013).

Conclusions: Our study suggested that rs16901946 G allele carriers have an increased risk of gastric cancer, and the risk could be enhanced by the interactions between the polymorphism and age, sex, Helicobacter pylori infection.

Keywords: Gastric cancer, polymorphism, lncRNA.

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How to cite this article:
He BS, Sun HL, Xu T, Pan YQ, Lin K, Gao TY, Zhang ZY, Wang SK. Association of Genetic Polymorphisms in the LncRNAs with Gastric Cancer Risk in a Chinese Population. J Cancer 2017; 8(4):531-536. doi:10.7150/jca.17519. Available from http://www.jcancer.org/v08p0531.htm