J Cancer 2017; 8(8):1477-1483. doi:10.7150/jca.18487

Research Paper

Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in Early Gastric Cancer (EGC)

Xueru Zhu1, Yiwei Wang1, Hongjia Li2, Wenji Xue1, Ruifen Wang3, Lifeng Wang3, Meiling Zhu1✉, Leizhen Zheng1✉

1. Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, Shanghai, China;
2. Department of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, 200092, Shanghai, China;
3. Department of Pathology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, Shanghai, China.

Abstract

Purpose: The aim of the study was to investigate the effect of deficiency of hMLH1 and hMSH2 expression on the prognosis of early gastric cancer (EGC) in Chinese populations.

Methods: A total of 160 EGC patients who underwent curative gastrectomy with lymphadenectomy from January 2011 to July 2014 at Xinhua Hospital were evaluated. The expression rates of hMLH1 and hMSH2 were examined using tissues preserved in paraffin blocks by immunohistochemical staining. The clinicopathological characteristics and prognosis of EGC with deficient hMLH1 and hMSH2 were analyzed.

Results: On immunohistochemical staining, the loss expression of hMLH1 and hMSH2 were observed in 89 (55.6%) and 45 (28.1%), respectively. The hMLH1 deficiency was associated with the middle third of tumor location (P = 0.041). According to Kaplan-Meier survival analysis and Log-Rank test, the loss expression of hMLH1 and hMSH2 were associated with worse survival than positive hMLH1 (HR = 0.247, 95% CI = 0.078-0.781, P = 0.017) and hMSH2 (HR = 0.174, 95% CI = 0.051-0.601, P = 0.006) in EGC.

Conclusion: The main conclusions were as follows: The hMLH1 deficiency was preferred to the middle third of EGC. Lymph node metastasis (LNM) was a prognostic factor of EGC. And the prognosis of EGC patients with deficient mismatch repair (dMMR, mainly including deficient hMLH1 and hMSH2) was obviously worse than proficient mismatch repair (pMMR).

Keywords: early gastric cancer, hMLH1, hMSH2, prognosis.

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How to cite this article:
Zhu X, Wang Y, Li H, Xue W, Wang R, Wang L, Zhu M, Zheng L. Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in Early Gastric Cancer (EGC). J Cancer 2017; 8(8):1477-1483. doi:10.7150/jca.18487. Available from http://www.jcancer.org/v08p1477.htm