1. Department of Biotechnology, MNNIT Allahabad-211004 2. Center of Bioinformatics, University of Allahabad, Allahabad-211002
✉ Corresponding author: E-mail: amaniac.in
Citation:
Maurya PK, Mishra A, Yadav BS, Singh S, Kumar P, Chaudhary A, Srivastava S, Murugesan SN, Mani A. Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target. J Cancer 2017; 8(10):1900-1907. doi:10.7150/jca.17689. https://www.jcancer.org/v08p1900.htm
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast cancer, colon cancer, lung cancer, gastric cancer, oesophageal cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of cancer proliferation. Knowledge about nuclear localization and nuclear level expression of YB-1 in different cancers has been correlated with prospective prognosis of cancer. This review discusses the prospects of YB-1 as a potential biomarker as well as therapeutic target in lieu of their role during cancer progression and multidrug resistance.
Keywords: Y Box Protein-1, cancer, biomarker
Citation styles
APA
Maurya, P.K., Mishra, A., Yadav, B.S., Singh, S., Kumar, P., Chaudhary, A., Srivastava, S., Murugesan, S.N., Mani, A. (2017). Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target. Journal of Cancer, 8(10), 1900-1907. https://doi.org/10.7150/jca.17689.
ACS
Maurya, P.K.; Mishra, A.; Yadav, B.S.; Singh, S.; Kumar, P.; Chaudhary, A.; Srivastava, S.; Murugesan, S.N.; Mani, A. Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target. J. Cancer 2017, 8 (10), 1900-1907. DOI: 10.7150/jca.17689.
NLM
Maurya PK, Mishra A, Yadav BS, Singh S, Kumar P, Chaudhary A, Srivastava S, Murugesan SN, Mani A. Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target. J Cancer 2017; 8(10):1900-1907. doi:10.7150/jca.17689. https://www.jcancer.org/v08p1900.htm
CSE
Maurya PK, Mishra A, Yadav BS, Singh S, Kumar P, Chaudhary A, Srivastava S, Murugesan SN, Mani A. 2017. Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target. J Cancer. 8(10):1900-1907.
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