J Cancer 2018; 9(3):488-493. doi:10.7150/jca.22107

Research Paper

Influence of diabetes on the risk of urothelial cancer according to body mass index: a 10-year nationwide population-based observational study

Woong Jin Bae1, Jin Bong Choi1,3, Hyong Woo Moon1, Young Hyun Park1,3, Hyuk Jin Cho1, Sung-Hoo Hong1,3, Ji Youl Lee1,3, Sae Woong Kim1, Kyung-Do Han2, U-Syn Ha1,3✉

1. Department of Urology, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea;
2. Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
3. Cancer Research Institute, the Catholic University of Korea, Seoul, Republic of Korea.

Abstract

To examine the association between obesity and urothelial cancer, we used a representative data from the National Health Insurance System (NHIS). Participants included 826,170 men aged 20 years and older who experienced a health examination at least one time between 2004 and 2008. The study thus excluded people aged <20 years and women. We used a multivariate adjusted Cox regression analysis to examine the association between urothelial cancer and body mass index (BMI) via a hazard ratio (HR) and 95% confidence interval (CI).

The age- or multivariable-adjusted HR for urothelial cancer was stratified by BMI. Men with a higher BMI were more likely to acquire urothelial cancer independent of variables. In the population with diabetes, there showed a considerable, increasing trend in the risk of urothelial cancer in the overweight and obesity group, compared to the group with the same BMI but without diabetes. This population-based study showed evidence of an association between obesity and the development of urothelial cancer, where the presence of diabetes increased the risk of urothelial cancer. Additionally, the higher the BMI, the higher the risk for urothelial cancer.

Keywords: Carcinoma, Urothelial Cancer, Obesity, Diabetes Mellitus.

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How to cite this article:
Bae WJ, Choi JB, Moon HW, Park YH, Cho HJ, Hong SH, Lee JY, Kim SW, Han KD, Ha US. Influence of diabetes on the risk of urothelial cancer according to body mass index: a 10-year nationwide population-based observational study. J Cancer 2018; 9(3):488-493. doi:10.7150/jca.22107. Available from http://www.jcancer.org/v09p0488.htm