J Cancer 2018; 9(7):1287-1300. doi:10.7150/jca.22020

Review

Evaluation of Detection Methods and Values of Circulating Vascular Endothelial Growth Factor in Lung Cancer

Sumin Guo1,2, Michael G. Martin3, Cheng Tian2, Jinglin Cui2,4, Lishi Wang5, Shucai Wu1✉, Weikuan Gu2,6✉

1. Department of Oncology, Hebei Chest Hospital, Lung Cancer Control and Prevention Center of Hebei Province, Shijiazhuang, Hebei, 050041, China
2. Department of Orthopaedic Surgery- Campbell Clinic and Pathology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
3. West Cancer Center, University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA.
4. Center of Integrative Research, The First Hospital of Qiqihaer City, Qiqihaer, Heilongjiang, 161005, PR China
5. Department of Basic Medicine (Basic Medical Research), Inner Mongolia Medical University, Inner Mongolia, 010110, PR China
6. Research Service, Veterans Affairs Medical Center, 1030 Jefferson Avenue, Memphis TN 38104, USA

Abstract

Lung cancer is the deadliest cancer in the world. Angiogenesis plays a crucial role of the incidence, progression, and metastasis in lung cancer. Angiogenesis inhibitors are used to treat non-small cell lung cancer (NSCLC) patients, and the molecular biomarkers are also being assessed to predict treatment response/therapeutic response and patients' prognosis. Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates angiogenesis. Due to its predictive values of prognosis on NSCLC, a large number of methods have been developed and evaluated to detect VEGF levels in a variety of studies. In this article, we review the detection methods designed to measure the VEGF levels in different body fluids and prognosticate the value of VEGF in treatment, diagnosis and survival in lung cancer.

Keywords: NSCLC, small cell lung cancer (SCLC), VEGF, evaluation, angiogenesis, biomarker

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How to cite this article:
Guo S, Martin MG, Tian C, Cui J, Wang L, Wu S, Gu W. Evaluation of Detection Methods and Values of Circulating Vascular Endothelial Growth Factor in Lung Cancer. J Cancer 2018; 9(7):1287-1300. doi:10.7150/jca.22020. Available from http://www.jcancer.org/v09p1287.htm