J Cancer 2018; 9(10):1765-1772. doi:10.7150/jca.24573

Research Paper

The prognosis of neck residue nasopharyngeal carcinoma (NPC) patients: results from a case-cohort study

Sai-Lan Liu 1,2#, Lin-Quan Tang1,2#, Qiu-Yan Chen1,2, Huan-Xin Lin1, Qi Yang1,2, Qian Zhu1, Wen Wen1,2, Shan-Shan Guo1,2, Li-Ting Liu1,2, Yang Li 1,2, Hao-Jun Xie 1,2, Qing-Nan Tang 1,2, Xue-Song Sun 1,2, Yu-Jing Liang 1,2, Xiao-Yun Li 1,2, Jin-Jie Yan 1,2, Chao Lin 1,2, Xiao-Wen Lan3,4, Hai-Qiang Mai 1,2✉*, Ling Guo1,2✉*

1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine
2. Department of Nasopharyngeal Carcinoma; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
3. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
4. Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
#These authors contributed equally to this article.
*The senior authors contributed equally to this work.

Abstract

Background: To assess the prognosis of neck residue nasopharyngeal carcinoma (NPC) patients and the efficacy of neck dissection in the treatment of these patients.

Methods: We recruited 68 neck residue NPC patients. For each neck residue patient we had three matched NPC patients without neck residue as controls (n = 204). The primary endpoint was progression-free survival (PFS). The Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), and multivariable analysis was used to test the independent statistical significance of NPC patients.

Results: Compared to controls, the neck residue patients showed significantly lower 3-year PFS (46.7% vs. 87.6%; P < 0.001). Multivariable analysis showed that neck residue was an independent prognostic factor for PFS.

Conclusions: NPC patients who had pathologically proven neck residue are associated with poor prognosis. Management with neck dissection alone seems not to be sufficient for these patients.

Keywords: nasopharyngeal carcinoma, neck residue, prognosis, neck dissection, case-cohort study

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How to cite this article:
Liu SL, Tang LQ, Chen QY, Lin HX, Yang Q, Zhu Q, Wen W, Guo SS, Liu LT, Li Y, Xie HJ, Tang QN, Sun XS, Liang YJ, Li XY, Yan JJ, Lin C, Lan XW, Mai HQ, Guo L. The prognosis of neck residue nasopharyngeal carcinoma (NPC) patients: results from a case-cohort study. J Cancer 2018; 9(10):1765-1772. doi:10.7150/jca.24573. Available from http://www.jcancer.org/v09p1765.htm