J Cancer 2018; 9(13):2334-2340. doi:10.7150/jca.25829

Review

Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment

Mengting Ding1,2*, Yuhan Liu1,3*, Xinhui Liao3*, Hengji Zhan1,3, Yuchen Liu3✉, Weiren Huang3✉

1. Department of Urology, Shenzhen Second People′s Hospital, the First Affiliated Hospital of Shenzhen University, Clinical Medicine College of Anhui Medical University, Shenzhen 518000, Guangdong, China.
2. Anhui Medical University, Hefei 230032, Anhui Province, China
3. Department of Urology, Shenzhen Second People′s Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518000, China
* Equal contributors

Abstract

Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of gene transcription. The in-depth study of eRNAs is of great significance for us to better understand enhancer function and transcriptional regulation in various diseases. Therefore, eRNAs may be a potential therapeutic target for diseases. Here, we review the current knowledge of the characteristics of eRNAs, the molecular mechanisms of eRNAs action, as well as diseases related to dysregulation of eRNAs.

Keywords: Enhancer RNAs, Enhancers, Gene transcription, Associated diseases

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How to cite this article:
Ding M, Liu Y, Liao X, Zhan H, Liu Y, Huang W. Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment. J Cancer 2018; 9(13):2334-2340. doi:10.7150/jca.25829. Available from http://www.jcancer.org/v09p2334.htm