1. Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, China. 2. Department of Pathology, Ohio State Wexner Medical Center, Columbus, OH 43210, USA. 3. Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center. 300 Halket St, Pittsburgh, PA, 15213, USA.
✉ Corresponding author: Min Hao, MD. Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, 382 Wuyi Rd, Taiyuan, China. Email :2yuanhaomincom; Chengquan Zhao, Department of Pathology, Magee-Womens Hospital, University of Pittsburgh Medical Center. 300 Halket St, Pittsburgh, PA, 15213, USA.More
Citation:
Wang Z, Li Z, Li J, Wang C, Wang W, Hao M, Zhao C. Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China. J Cancer 2018; 9(16):2802-2806. doi:10.7150/jca.25614. https://www.jcancer.org/v09p2802.htm
Objective: The distribution of human papillomavirus (HPV) genotypes varies by countries and regions. Data regarding HPV genotype distribution for women with cervical intraepithelial neoplasia 2/3 (CIN2/3) are still limited. This study aimed to investigate the distribution of HPV genotypes for women with CIN2/3 in Shanxi province, China.
Methods: Prior HPV testing/genotyping resulted from women with histologic diagnosis of CIN2/3 were retrospectively collected between August 2011 and August 2016.
Results: A total of 1387 women with a diagnosis of CIN2/3 were included in this study. The average age of the women was 45.7 years and the average time period from HPV testing to histological diagnosis was 0.4 months. The overall high-risk HPV (hrHPV) positive rate was 91.6%. In all tested women, the most commonly detected hrHPV genotype was HPV16 (59.3%) followed by HPV58 (14.4%) and HPV33 (10.0%), while HPV18 was in the 6th position (6.0%).
Conclusions: This is one of the largest studies of HPV genotyping for women with CIN2/3 in China. The prevalence and distribution of HPV genotypes in these Chinese women differed from those in women from Western countries. Our results provide important information for developing specific HPV vaccines for Chinese women.
Wang, Z., Li, Z., Li, J., Wang, C., Wang, W., Hao, M., Zhao, C. (2018). Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China. Journal of Cancer, 9(16), 2802-2806. https://doi.org/10.7150/jca.25614.
ACS
Wang, Z.; Li, Z.; Li, J.; Wang, C.; Wang, W.; Hao, M.; Zhao, C. Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China. J. Cancer 2018, 9 (16), 2802-2806. DOI: 10.7150/jca.25614.
NLM
Wang Z, Li Z, Li J, Wang C, Wang W, Hao M, Zhao C. Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China. J Cancer 2018; 9(16):2802-2806. doi:10.7150/jca.25614. https://www.jcancer.org/v09p2802.htm
CSE
Wang Z, Li Z, Li J, Wang C, Wang W, Hao M, Zhao C. 2018. Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China. J Cancer. 9(16):2802-2806.
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