Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection

Jiang, Yiquan; Tang, Hui; Wang, Zixian; Sun, Yuanjing; Meng, Wei; Wang, Guoying; Li, Hua; Yi, Shuhong; Wang, Genshu; Yang, Yang; Chen, Guihua

doi:10.7150/jca.25899

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J Cancer 2018; 9(18):3287-3294. doi:10.7150/jca.25899 This issue Cite

Research Paper

Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection

Yiquan Jiang^1*, Hui Tang^2*, Zixian Wang³, Yuanjing Sun¹, Wei Meng¹, Guoying Wang^1✉, Hua Li¹, Shuhong Yi¹, Genshu Wang¹, Yang Yang^1,2, Guihua Chen^1,2✉

1. Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University; Organ Transplantation Research Center of Guangdong Province.
2. Key Laboratory of Liver Disease Research of Guangdong Province, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
3. Department of Medical Oncology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, China.
*These authors contributed equally as first authors.

Citation:

Jiang Y, Tang H, Wang Z, Sun Y, Meng W, Wang G, Li H, Yi S, Wang G, Yang Y, Chen G. Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection. J Cancer 2018; 9(18):3287-3294. doi:10.7150/jca.25899. https://www.jcancer.org/v09p3287.htm

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Abstract

Background: Hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion (MaVI) have limited lifespans. According to recent studies, surgical treatment may be the most promising option. However, the current staging system does not select patients who will benefit most from hepatic resection.

Study design: A total of 123 patients undergoing hepatic resection for HCC with macroscopic vascular invasion (MaVI) between 2010 and 2014 at The Third Affiliated Hospital of Sun Yat-sen University were selected. We developed nomograms for overall survival (OS) and recurrence-free survival (RFS) using a Cox proportional hazards model. We assessed nomogram model performance based on the concordance index (C-index) and a calibration plot.

Results: The 1- and 3-year overall survival (OS) rates for all patients were 84% and 71%, respectively. Correspondingly, the 1- and 3-year recurrence-free survival (RFS) rates were 55% and 35%, respectively. In the multivariate Cox model, the extent of vascular invasion, tumour count, fibrinogen, HBV DNA load and serum potassium significantly affected prognosis. The C-index of the two nomograms were 0.80 and 0.69 for OS and RFS respectively. Based on our nomogram, patients predicted to have 1-year and 3-year RFS rates of more than 80% and 56% had actual 1-year and 3-year RFS rates of 81.8% and 57.1%, respectively, including 9.0% and 17.1% of the HCC patients with MaVI in our database.

Conclusion: Surgical treatments are a therapeutic option that can provide more survival benefit for HCC patients with MaVI. With the help of our nomograms, selected HCC patients with MaVI can benefit from hepatic resection and have the same survival rate as that for early-stage HCC patients.

Keywords: Hepatocellular carcinoma, Macroscopic vascular invasion, Hepatic resection, Prognostic predictive model, Nomogram

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APA

Jiang, Y., Tang, H., Wang, Z., Sun, Y., Meng, W., Wang, G., Li, H., Yi, S., Wang, G., Yang, Y., Chen, G. (2018). Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection. Journal of Cancer, 9(18), 3287-3294. https://doi.org/10.7150/jca.25899.

ACS

Jiang, Y.; Tang, H.; Wang, Z.; Sun, Y.; Meng, W.; Wang, G.; Li, H.; Yi, S.; Wang, G.; Yang, Y.; Chen, G. Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection. J. Cancer 2018, 9 (18), 3287-3294. DOI: 10.7150/jca.25899.

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CSE

Jiang Y, Tang H, Wang Z, Sun Y, Meng W, Wang G, Li H, Yi S, Wang G, Yang Y, Chen G. 2018. Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection. J Cancer. 9(18):3287-3294.

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