J Cancer 2018; 9(23):4404-4412. doi:10.7150/jca.27015

Research Paper

The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer

Jian-Xian Lin1,2,3*, Xin-Sheng Xie1,2,3*, Xiong-Feng Weng1,2,3, Chao-Hui Zheng1,2,3, Jian-Wei Xie1,2,3, Jia-Bin Wang1,2,3, Jun Lu1,2,3, Qi-Yue Chen1,2, Long-Long Cao1,2, Mi Lin1,2, Ru-Hong Tu1,2, Chang-Ming Huang1,2,3✉, Ping Li1,2,3✉

1. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China
2. Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China
3. Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, Fujian Province, China
*Jian-Xian Lin and Xin-Sheng Xie contributed equally to this work and should be considered co-first authors.

Abstract

Purpose To discuss the relationship between the clinicopathological data, long-term survival of gastric cancer patients and different expression levels of Cyclin-Dependent Kinase 5 (CDK5) and Protein Phosphatase 2A (PP2A).

Method The expression levels of CDK5 and PP2A were detected by immunohistochemistry in specimens from 124 patients with primary gastric cancer. The correlation among the expression of CDK5 and PP2A, clinicopathological factors and prognosis was investigated.

Result The expression level of CDK5 was correlated with the TNM stage (p=0.030) and N stage (p=0.001), while the expression level of PP2A was correlated with the TNM stage and N stage (p=0.001 and p=0.004) as well as the degree of differentiation (p=0.046). The expression of CDK5 was positively correlated with the expression of PP2A in gastric cancer. Co-expression of CDK5 and PP2A is an independent prognostic factor that affected overall survival, and provided more accurate prognostic value for the overall survival of gastric cancer patients.

Conclusion The expression of CDK5 and PP2A is positively correlated in gastric cancer. Co-expression of CDK5 and PP2A was an independent prognostic factor in patients with gastric cancer.

Keywords: CDK5, PP2A, prognosis, gastric cancer

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How to cite this article:
Lin JX, Xie XS, Weng XF, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Huang CM, Li P. The prognostic value of Cyclin-Dependent Kinase 5 and Protein Phosphatase 2A in Gastric Cancer. J Cancer 2018; 9(23):4404-4412. doi:10.7150/jca.27015. Available from http://www.jcancer.org/v09p4404.htm