J Cancer 2019; 10(2):441-448. doi:10.7150/jca.30041

Research Paper

miR-1307-3p Stimulates Breast Cancer Development and Progression by Targeting SMYD4

Sanghak Han1*, Hua Zou 2*, Jin-Won Lee4, Jeonghee Han3, Heung Cheol Kim5, Jeong Jin Cheol6, Lee-Su Kim7, Haesung Kim3✉

1. Department of Pathology, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon 24253, Gangwon-Do, South Korea;
2. Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China;
3. Department of Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Gangwon-Do 24253, South Korea;
4. Department of Pharmacology, Scholl of Medicine, Kangwon National University, Chunchon 200-701, South Korea;
5. Department of Radiology, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Gangwon-Do 24253, South Korea;
6. Department of Surgery, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 134-776, South Korea;
7. Department of Surgery, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14086, Gyeonggi-Do, South Korea.
*These authors contributed equally to this work.

Abstract

Recent studies show that dysregulated miRNAs play an important role in breast cancer initiation and progression. Here, we identified upregulated expression of miR-1307-3p in breast cancer tissues and that increased level of miR-1307-3p was closely correlated with lower survival rate in breast cancer patients. Consistent with clinical data, our in vitro data show that expression level of miR-1307-3p was significantly increased in breast cancer cell lines compared to human mammary epithelial cell line MCF10A. Overexpression of miR-1307-3p in MCF10A stimulated cell proliferation and caused their growth in soft agar and tumor formation in nude mice. In contrast, inhibition of miR-1307-3p suppressed breast cancer cell proliferation and their growth in soft agar and inhibited tumor formation in nude mice. Further, we identified that miR-1307-3p plays its oncogenic role through targeting SET and MYND domain-containing 4 (SMYD4) expression in breast cancer. Taken together, our findings suggest that miR-1307-3p is a oncogenic miRNA that significantly contributes to breast cancer development and progression, and inhibition of miR-1307-3p may be a novel strategy for inhibits breast cancer initiation and progression.

Keywords: breast cancer, tumorigenesis, miR-1307-3p, SMYD4

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Han S, Zou H, Lee JW, Han J, Kim HC, Cheol JJ, Kim LS, Kim H. miR-1307-3p Stimulates Breast Cancer Development and Progression by Targeting SMYD4. J Cancer 2019; 10(2):441-448. doi:10.7150/jca.30041. Available from http://www.jcancer.org/v10p0441.htm