J Cancer 2019; 10(4):810-818. doi:10.7150/jca.30300

Review

Scar tissue to lung cancer; pathways and treatment

Konstantinos Sapalidis1✉, Chrysanthi Sardeli2, Efstathios Pavlidis1, Georgios Koimtzis1, Charilaos Koulouris1, Nikolaos Michalopoulos1, Stylianos Mantalovas1, Theodora Tsiouda1, Ioannis Passos1, Christoforos Kosmidis1, Dimitrios Giannakidis1, Valeriu Surlin1, Athanasios Katsaounis1, Vyron Alexandrou1, Aikaterini Amaniti3, Paul Zarogoulidis1,2✉, Haidong Huang4, Qiang Li4, Stelian Mogoanta5, Isaac Kesisoglou1

1. Third Department of Surgery, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece;
2. Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece;
3. Anaisthisiology Department, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
4. The Diagnostic and Therapeutic Center of Respiratory Diseases, Shanghai East Hospital, Tongji University, Shanghai, China.
5. Department of Surgery, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Abstract

Lung cancer still remains diagnosed at a late stage although we have novel diagnostic techniques at our disposal. However; for metastatic disease we have novel therapies based on pharmacogenomics. Tumor heterogenity provides us different treatments. There are several reasons for carcinogenesis; fibrosis and scar tissue provides an environment that induces malignancy. In the current review we will try and elucidate the pathways involved from scar tissue to carcinogenesis.

Keywords: lung cancer, scar tissue, interstitial disease, fibrosis, pathways

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How to cite this article:
Sapalidis K, Sardeli C, Pavlidis E, Koimtzis G, Koulouris C, Michalopoulos N, Mantalovas S, Tsiouda T, Passos I, Kosmidis C, Giannakidis D, Surlin V, Katsaounis A, Alexandrou V, Amaniti A, Zarogoulidis P, Huang H, Li Q, Mogoanta S, Kesisoglou I. Scar tissue to lung cancer; pathways and treatment. J Cancer 2019; 10(4):810-818. doi:10.7150/jca.30300. Available from http://www.jcancer.org/v10p0810.htm