Scar tissue to lung cancer; pathways and treatment

Sapalidis, Konstantinos; Sardeli, Chrysanthi; Pavlidis, Efstathios; Koimtzis, Georgios; Koulouris, Charilaos; Michalopoulos, Nikolaos; Mantalovas, Stylianos; Tsiouda, Theodora; Passos, Ioannis; Kosmidis, Christoforos; Giannakidis, Dimitrios; Surlin, Valeriu; Katsaounis, Athanasios; Alexandrou, Vyron; Amaniti, Aikaterini; Zarogoulidis, Paul; Huang, Haidong; Li, Qiang; Mogoanta, Stelian; Kesisoglou, Isaac

doi:10.7150/jca.30300

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J Cancer 2019; 10(4):810-818. doi:10.7150/jca.30300 This issue Cite

Review

Scar tissue to lung cancer; pathways and treatment

Konstantinos Sapalidis^1✉, Chrysanthi Sardeli², Efstathios Pavlidis¹, Georgios Koimtzis¹, Charilaos Koulouris¹, Nikolaos Michalopoulos¹, Stylianos Mantalovas¹, Theodora Tsiouda¹, Ioannis Passos¹, Christoforos Kosmidis¹, Dimitrios Giannakidis¹, Valeriu Surlin¹, Athanasios Katsaounis¹, Vyron Alexandrou¹, Aikaterini Amaniti³, Paul Zarogoulidis^1,2✉, Haidong Huang⁴, Qiang Li⁴, Stelian Mogoanta⁵, Isaac Kesisoglou¹

1. Third Department of Surgery, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece;
2. Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece;
3. Anaisthisiology Department, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece.
4. The Diagnostic and Therapeutic Center of Respiratory Diseases, Shanghai East Hospital, Tongji University, Shanghai, China.
5. Department of Surgery, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Citation:

Sapalidis K, Sardeli C, Pavlidis E, Koimtzis G, Koulouris C, Michalopoulos N, Mantalovas S, Tsiouda T, Passos I, Kosmidis C, Giannakidis D, Surlin V, Katsaounis A, Alexandrou V, Amaniti A, Zarogoulidis P, Huang H, Li Q, Mogoanta S, Kesisoglou I. Scar tissue to lung cancer; pathways and treatment. J Cancer 2019; 10(4):810-818. doi:10.7150/jca.30300. https://www.jcancer.org/v10p0810.htm

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Abstract

Lung cancer still remains diagnosed at a late stage although we have novel diagnostic techniques at our disposal. However; for metastatic disease we have novel therapies based on pharmacogenomics. Tumor heterogenity provides us different treatments. There are several reasons for carcinogenesis; fibrosis and scar tissue provides an environment that induces malignancy. In the current review we will try and elucidate the pathways involved from scar tissue to carcinogenesis.

Keywords: lung cancer, scar tissue, interstitial disease, fibrosis, pathways

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APA

Sapalidis, K., Sardeli, C., Pavlidis, E., Koimtzis, G., Koulouris, C., Michalopoulos, N., Mantalovas, S., Tsiouda, T., Passos, I., Kosmidis, C., Giannakidis, D., Surlin, V., Katsaounis, A., Alexandrou, V., Amaniti, A., Zarogoulidis, P., Huang, H., Li, Q., Mogoanta, S., Kesisoglou, I. (2019). Scar tissue to lung cancer; pathways and treatment. Journal of Cancer, 10(4), 810-818. https://doi.org/10.7150/jca.30300.

ACS

Sapalidis, K.; Sardeli, C.; Pavlidis, E.; Koimtzis, G.; Koulouris, C.; Michalopoulos, N.; Mantalovas, S.; Tsiouda, T.; Passos, I.; Kosmidis, C.; Giannakidis, D.; Surlin, V.; Katsaounis, A.; Alexandrou, V.; Amaniti, A.; Zarogoulidis, P.; Huang, H.; Li, Q.; Mogoanta, S.; Kesisoglou, I. Scar tissue to lung cancer; pathways and treatment. J. Cancer 2019, 10 (4), 810-818. DOI: 10.7150/jca.30300.

NLM

CSE

Sapalidis K, Sardeli C, Pavlidis E, Koimtzis G, Koulouris C, Michalopoulos N, Mantalovas S, Tsiouda T, Passos I, Kosmidis C, Giannakidis D, Surlin V, Katsaounis A, Alexandrou V, Amaniti A, Zarogoulidis P, Huang H, Li Q, Mogoanta S, Kesisoglou I. 2019. Scar tissue to lung cancer; pathways and treatment. J Cancer. 10(4):810-818.

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