J Cancer 2019; 10(4):821-828. doi:10.7150/jca.27899

Research Paper

KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients

Xin-Hui Fu1,2,3,*, Zhi-Ting Chen1,2,3,*, Wen-Hui Wang4,*, Xin-Juan Fan3, Yan Huang3, Xiao-Bin Wu5, Jing-Lin Huang1,2,3, Jing-Xuan Wang1,2,3, Han-Jie Lin1,2,3, Xiao-Li Tan1,2,3, Lei Wang5✉, Jian-Ping Wang1,2✉

1. Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China
2. Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China
3. Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China
4. Department of Information and Technology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China
5. Department of GI Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China
* These authors have contributed equally to this work.

Abstract

This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the KRAS, BRAF, and PIK3CA mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. The results show that the frequency of KRAS, BRAF and PIK3CA mutations were 4.1%, 1.2% and 3.5%, respectively. BRAF mutations were significantly concentrated in stage III and IV gastric cancer (P=0.009). KRAS G12V mutation carriers have much shorter OS than other mutation carriers and wild-type group patients (P=0.013). In conclusion, only the KRAS G12V mutation has an adverse effect on patient survival.

Keywords: KRAS, BRAF, PIK3CA, Mutation, Gastric cancer

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How to cite this article:
Fu XH, Chen ZT, Wang WH, Fan XJ, Huang Y, Wu XB, Huang JL, Wang JX, Lin HJ, Tan XL, Wang L, Wang JP. KRAS G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients. J Cancer 2019; 10(4):821-828. doi:10.7150/jca.27899. Available from http://www.jcancer.org/v10p0821.htm