J Cancer 2019; 10(4):927-936. doi:10.7150/jca.27160

Review

5'-Methylthioadenosine and Cancer: old molecules, new understanding

Yaofeng Li1, Yubo Wang2, Ping Wu1✉

1. Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
2. College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.

Abstract

While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a century ago, altered metabolism has recently returned as a focus of cancer research. 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside found in numerous species. While MTA was first isolated several decades ago, a lack of sensitive and specific analytical methodologies designed for its direct quantification has hampered the study of its physiological and pathophysiological features. Many studies indicate that MTA suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. In this review, we assessed the effects of MTA and of related materials on the growth and functions of normal and malignant cells.

Keywords: Cancer, MTA, Metabolism, MTAP, Polyamine

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How to cite this article:
Li Y, Wang Y, Wu P. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer 2019; 10(4):927-936. doi:10.7150/jca.27160. Available from http://www.jcancer.org/v10p0927.htm