Multiple Myeloma: What Do We Do About Immunodeficiency?

Li, Linrong; Wang, Liang

doi:10.7150/jca.29993

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2019; 10(7):1675-1684. doi:10.7150/jca.29993 This issue Cite

Review

Multiple Myeloma: What Do We Do About Immunodeficiency?

Linrong Li¹, Liang Wang^2✉

1. Second Clinical Medical College, Southern Medical University, Guangzhou, China.
2. Department of Hematology, ZhuJiang Hospital of Southern Medical University, Guangzhou, China.

Citation:

Li L, Wang L. Multiple Myeloma: What Do We Do About Immunodeficiency?. J Cancer 2019; 10(7):1675-1684. doi:10.7150/jca.29993. https://www.jcancer.org/v10p1675.htm

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Abstract

Multiple myeloma (MM) is an incurable hematological malignancy. Immunodeficiency results in the incapability of immunity to eradicate both tumor cells and pathogens. Immunotherapies along with antibiotics and other anti-infectious agents are applied as substitutes for immunity in MM. Immunotherapies including monoclonal antibodies, immune checkpoints inhibitors, affinity- enhanced T cells, chimeric antigen receptor T cells and dendritic cell vaccines are revolutionizing MM treatment. By suppressing the pro-inflammatory milieu and pathogens, prophylactic and therapeutic antibiotics represent anti-tumor and anti-infection properties. It is expected that deeper understanding of infection, immunity and tumor physio-pathologies in MM will accelerate the optimization of combined therapies, thus improving prognosis in MM.

Keywords: immunodeficiency, multiple myeloma, immunotherapy, antibiotic

Citation styles

APA

Li, L., Wang, L. (2019). Multiple Myeloma: What Do We Do About Immunodeficiency?. Journal of Cancer, 10(7), 1675-1684. https://doi.org/10.7150/jca.29993.

ACS

Li, L.; Wang, L. Multiple Myeloma: What Do We Do About Immunodeficiency?. J. Cancer 2019, 10 (7), 1675-1684. DOI: 10.7150/jca.29993.

NLM

Li L, Wang L. Multiple Myeloma: What Do We Do About Immunodeficiency?. J Cancer 2019; 10(7):1675-1684. doi:10.7150/jca.29993. https://www.jcancer.org/v10p1675.htm

CSE

Li L, Wang L. 2019. Multiple Myeloma: What Do We Do About Immunodeficiency?. J Cancer. 10(7):1675-1684.

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