Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma

Chen, Pengxiang; Wang, Cong; Song, Qingxu; Chen, Tong; Jiang, Jinxiu; Zhang, Xiaoli; Xu, Jiaqi; Cui, Jianfeng; Cheng, Yufeng

doi:10.7150/jca.30172

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J Cancer 2019; 10(9):1968-1974. doi:10.7150/jca.30172 This issue Cite

Research Paper

Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma

Pengxiang Chen¹, Cong Wang¹, Qingxu Song¹, Tong Chen², Jinxiu Jiang³, Xiaoli Zhang⁴, Jiaqi Xu⁵, Jianfeng Cui⁶, Yufeng Cheng^1✉

1. Department of Radiation Oncology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China
2. Department of Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, People's Republic of China
3. Intensive Care Unit, the People's Hospital of Pingyi, 7Jinhua Road, Pingyi, 273300, People's Republic of China
4. Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong University, 440 Jiyan Road, Jinan, 250117, People's Republic of China
5. Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Hangzhou, 310016, People's Republic of China
6. Department of Urology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China

Citation:

Chen P, Wang C, Song Q, Chen T, Jiang J, Zhang X, Xu J, Cui J, Cheng Y. Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma. J Cancer 2019; 10(9):1968-1974. doi:10.7150/jca.30172. https://www.jcancer.org/v10p1968.htm

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Abstract

Background Sleep duration and snoring are correlated with tumorigenesis while their associations with esophageal squamous cell carcinoma (ESCC) are unclear. The purpose of this study is to investigate the impacts of night sleep duration and snoring on ESCC risk.

Methods This study included a total of 527 esophageal squamous cell carcinoma patients and 505 gender- and age- matched healthy controls from five hospitals in China. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by conditional logistic regression models.

Results Subjects with sleep duration <7 h (adjusted OR 3.18, 95%CI 1.55-6.53) and regular snoring (adjusted OR 2.56, 95%CI 1.82-3.59) were exposed to high esophageal squamous cell carcinoma risk. After the multivariate models adjusted for body mass index (BMI), the results changed slightly. In the stratified analysis regarding gender, the similar trends occurred in both men and women, and BMI ≥25.0 kg/m² (adjusted OR 0.68, 95%CI 0.48-0.96) was associated with decreased esophageal squamous cell carcinoma risk in men. Additionally, the esophageal squamous cell carcinoma risk attributable to sleep duration <7 h and regular snoring could be completely or partially diminished in subjects with BMI ≥25.0 kg/m².

Conclusion In both genders, short sleep duration (<7h) and regular snoring were significantly related to increased risk of esophageal squamous cell carcinoma independently.

Keywords: Sleep duration, Snoring, Esophageal squamous cell carcinoma, Cancer prevention, Epidemiology

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APA

Chen, P., Wang, C., Song, Q., Chen, T., Jiang, J., Zhang, X., Xu, J., Cui, J., Cheng, Y. (2019). Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma. Journal of Cancer, 10(9), 1968-1974. https://doi.org/10.7150/jca.30172.

ACS

Chen, P.; Wang, C.; Song, Q.; Chen, T.; Jiang, J.; Zhang, X.; Xu, J.; Cui, J.; Cheng, Y. Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma. J. Cancer 2019, 10 (9), 1968-1974. DOI: 10.7150/jca.30172.

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CSE

Chen P, Wang C, Song Q, Chen T, Jiang J, Zhang X, Xu J, Cui J, Cheng Y. 2019. Impacts of Sleep Duration and Snoring on The Risk of Esophageal Squamous Cell Carcinoma. J Cancer. 10(9):1968-1974.

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