J Cancer 2019; 10(10):2229-2236. doi:10.7150/jca.27134

Research Paper

Clinical significance of serum markers reflecting gastric function and H. pylori infection in colorectal cancer

Qing-yue Zhang1,2,3, Zhi Lv1,2,3, Li-ping Sun1,2,3, Nan-nan Dong1,2,3, Cheng-zhong Xing1,2,3, Yuan Yuan1,2,3✉

1. Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China
2. Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang 110001, China
3. Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang 110001, China

Abstract

Purpose: The study was conducted to investigate the relationship of serum pepsinogens PGI, PGII, gastrin-17, and Hp-IgG with colorectal cancer (CRC), aiming to explore the clinical significance of serum markers reflecting gastric function and H. pylori infection in CRC.

Methods: A total of 569 CRC cases and 569 age and sex-matched controls were enrolled in this study between June 2012 and April 2016 from The First Hospital of China Medical University. The serum markers reflecting gastric function and H. pylori infection were detected using ELISA, including PGI, PGII, PGI/II ratio, G-17 and Hp-IgG. Information of clinicopathological parameters and tumor biomarkers was collected from the medical records of inpatients, including CEA, CA199, CA125, CA153 and AFP.

Results: Serum PGII, G-17 levels and Hp-IgG were increased in CRC, while PGI and PGI/II ratio appeared no significant difference between CRC and controls. In subgroup analysis, PGII was more significant in males (P=0.014). Hp-IgG was demonstrated higher in age<60y (P=0.001). With respect to the association with serum tumor biomarkers, G-17 level was associated with the rise of CA125 (P=0.005, OR (95%CI): 4.89 (1.90-12.57)), Hp-IgG increasing was associated with the rise of CA125 (P=0.024, OR (95%CI): 4.10 (1.54-10.93)).

Conclusions: Serum PGII, G-17 and Hp-IgG were associated with CRC risk. The serum levels of G-17 and Hp-IgG were associated with the rise of CA125 in patients with CRC

Keywords: Gastric function, Pepsinogens, Gastrin, H. pylori, Colorectal cancer

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How to cite this article:
Zhang Qy, Lv Z, Sun Lp, Dong Nn, Xing Cz, Yuan Y. Clinical significance of serum markers reflecting gastric function and H. pylori infection in colorectal cancer. J Cancer 2019; 10(10):2229-2236. doi:10.7150/jca.27134. Available from http://www.jcancer.org/v10p2229.htm