J Cancer 2019; 10(10):2350-2356. doi:10.7150/jca.30474

Research Paper

Is Routine Subcarinal Lymph Node Dissection Necessary in Superficial Esophageal Squamous Cell Carcinoma? A Propensity Score Matching Analysis

Han Tang, Lijie Tan, Hao Wang, Yaxing Shen, Jun Yin, Yong Fang, Qun Wang

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

Abstract

Background: The purpose of this study was to investigate the impact of subcarinal lymph node dissection on short-term and long-term outcomes after esophagectomy in patients with superficial esophageal squamous cell carcinoma (ESCC).

Methods: From January 2010 to December 2015, 490 patients with pT1 ESCC were enrolled in the study. Patients in subcarinal dissection or non-dissection group were matched randomly in a 2:1 ratio, eventually, 255 patients were selected for further statistical analysis.

Results: The metastasis rate of subcarinal lymph nodes in superficial ESCC was 1.24% and significantly lower than the other stations (7.14-9.96%). Compared with dissection group, non- dissection group had shorter operation time (193±35 vs. 204±39, P=0.016), less blood loss (157±48 vs. 178±29, P=0.011) as well as lower incidence of pulmonary complications (9.4 vs. 20%, P=0.032). At a median follow-up of 46 months, the recurrent rate in each group was similar (16.5 vs. 15.3%, P=0.809). Survival analysis revealed no overall survival (P=0.992) and disease-free survival (P=0.665) reductions in non-dissection group. In univariate and multivariate analyses, subcarinal lymph node dissection was not a predictive factor of overall and disease-free survival in superficial ESCC.

Conclusion: Subcarinal lymph node dissection was not beneficial and could be omitted in superficial ESCC.

Keywords: subcarinal lymph node dissection, superficial esophageal squamous cell carcinoma, complication, recurrence, survival

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How to cite this article:
Tang H, Tan L, Wang H, Shen Y, Yin J, Fang Y, Wang Q. Is Routine Subcarinal Lymph Node Dissection Necessary in Superficial Esophageal Squamous Cell Carcinoma? A Propensity Score Matching Analysis. J Cancer 2019; 10(10):2350-2356. doi:10.7150/jca.30474. Available from http://www.jcancer.org/v10p2350.htm