The Role of the Slit/Robo Signaling Pathway

Tong, Mingfu; Jun, Tie; Nie, Yongzhan; Hao, Jianyu; Fan, Daiming

doi:10.7150/jca.31877

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J Cancer 2019; 10(12):2694-2705. doi:10.7150/jca.31877 This issue Cite

Review

The Role of the Slit/Robo Signaling Pathway

Mingfu Tong^1,2, Tie Jun^2✉, Yongzhan Nie², Jianyu Hao^1✉, Daiming Fan^2✉

1. Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
2. State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Citation:

Tong M, Jun T, Nie Y, Hao J, Fan D. The Role of the Slit/Robo Signaling Pathway. J Cancer 2019; 10(12):2694-2705. doi:10.7150/jca.31877. https://www.jcancer.org/v10p2694.htm

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Abstract

The Slit family is a family of secreted proteins that play important roles in various physiologic and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first identified in the nervous system, where it functions in neuronal axon guidance; nevertheless, an increasing number of studies have shown that Slit/Robo signaling even regulates other activities, such as angiogenesis, inflammatory cell chemotaxis, tumor cell migration and metastasis. Although the precise role of the ligand-receptor in organisms has been obscure and the conclusions drawn are sometimes paradoxical, tremendous advances in understanding the Slit/Robo signaling pathway have been made. As such, our review summarizes the characteristics of the Slit/Robo signaling pathway and its role in various cell types.

Keywords: Slit, Robo, neuro, angiogenesis, chemotaxis, cancer, motility

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APA

Tong, M., Jun, T., Nie, Y., Hao, J., Fan, D. (2019). The Role of the Slit/Robo Signaling Pathway. Journal of Cancer, 10(12), 2694-2705. https://doi.org/10.7150/jca.31877.

ACS

Tong, M.; Jun, T.; Nie, Y.; Hao, J.; Fan, D. The Role of the Slit/Robo Signaling Pathway. J. Cancer 2019, 10 (12), 2694-2705. DOI: 10.7150/jca.31877.

NLM

Tong M, Jun T, Nie Y, Hao J, Fan D. The Role of the Slit/Robo Signaling Pathway. J Cancer 2019; 10(12):2694-2705. doi:10.7150/jca.31877. https://www.jcancer.org/v10p2694.htm

CSE

Tong M, Jun T, Nie Y, Hao J, Fan D. 2019. The Role of the Slit/Robo Signaling Pathway. J Cancer. 10(12):2694-2705.

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