ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2019; 10(14):3232-3238. doi:10.7150/jca.30159 This issue Cite
Research Paper
The mediating role of extent of resection in the relationship between the tumor characteristics and survival outcome of glioma
1. School of Public Health, Guangzhou Medical University, Guangzhou, China
2. Department of Neurosurgery/Neuro-oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
3. College of information science and technology, Jinan University, Guangzhou, China
* These authors contributed equally to this work.
Abstract
The prognostic value of tumor characteristics for glioma has been controversial, partly because of a lack of knowledge about how these associations develop. Extent of resection may be factors that mediate the relationship between tumor characteristics and the hazard of death from glioma.
Patients and Methods: This consecutive study retrospectively included a group of 393 treatment-naive patients with newly, pathologically confirmed glioma between January 2004 and December 2014. Information on patient age, gender, Karnofsky Performance Status (KPS), tumor grade, tumor size, tumor location, presence or absence of contrast enhancement on MRI and extent of tumor resection have all been collected. The discrete-time survival model integrating survival outcomes within structural equation models was employed to develop and evaluate a comprehensive hypothesis regarding the direct and indirect impact of tumor characteristics on the hazard of death from glioma, mediated by the extent of resection.
Results: Except for tumor location, the indirect effects of tumor grade, contrast enhancement, and tumor size on PFS of glioma through extent of resection were found significant in the model.
Conclusion: This study provides a better understanding of the process through which tumor characteristics is associated with hazard of death from glioma.
Keywords: Glioma, survival outcome, extent of resection, discrete-time survival model, structural equation model
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