Knockdown of LncRNA <i>RHPN1-AS1</i> Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma

Qiu, Xiaowen; Lei, Zhuo; Wang, Zeyou; Xu, Yuming; Liu, Chang; Li, Panchun; Wu, Hanjiang; Gong, Zhaojian

doi:10.7150/jca.29029

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J Cancer 2019; 10(17):4000-4008. doi:10.7150/jca.29029 This issue Cite

Research Paper

Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma

Xiaowen Qiu^1,2, Zhuo Lei³, Zeyou Wang⁴, Yuming Xu¹, Chang Liu¹, Panchun Li¹, Hanjiang Wu¹, Zhaojian Gong^1✉

1. Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China;
2. Department of Stomatology, Haikou people's Hospital, Haikou 570208, Hainan, China;
3. Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha 410008, Hunan, China;
4. Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China.

Citation:

Qiu X, Lei Z, Wang Z, Xu Y, Liu C, Li P, Wu H, Gong Z. Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma. J Cancer 2019; 10(17):4000-4008. doi:10.7150/jca.29029. https://www.jcancer.org/v10p4000.htm

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Abstract

Previous studies have revealed that long non-coding RNAs (lncRNAs) are involved in head and neck squamous cell carcinoma (HNSCC) progression. However, the detailed roles of lncRNA RHPN1-AS1 remain to be elucidated. In this study, by analyzing online RNA-Seq data, we found that RHPN1-AS1 was upregulated in HNSCC tissues and that its expression level was associated with neoplasm histologic grade. High expression of RHPN1-AS1 was also confirmed in HNSCC tissues. Knockdown of RHPN1-AS1 inhibited tumor cell migration, invasion and proliferation in HNSCC. Furthermore, inhibition of RHPN1-AS1 suppressed the expression of epithelial-mesenchymal transition (EMT)-related genes (β-Catenin, Claudin-1 and Vimentin) in HNSCC cells. Collectively, our results suggest that RHPN1-AS1, acting as an oncogene, may be a potential diagnostic and therapeutic target in HNSCC.

Keywords: Long non-coding RNA, RHPN1-AS1, HNSCC, EMT

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APA

Qiu, X., Lei, Z., Wang, Z., Xu, Y., Liu, C., Li, P., Wu, H., Gong, Z. (2019). Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma. Journal of Cancer, 10(17), 4000-4008. https://doi.org/10.7150/jca.29029.

ACS

Qiu, X.; Lei, Z.; Wang, Z.; Xu, Y.; Liu, C.; Li, P.; Wu, H.; Gong, Z. Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma. J. Cancer 2019, 10 (17), 4000-4008. DOI: 10.7150/jca.29029.

NLM

CSE

Qiu X, Lei Z, Wang Z, Xu Y, Liu C, Li P, Wu H, Gong Z. 2019. Knockdown of LncRNA RHPN1-AS1 Inhibits Cell Migration, Invasion and Proliferation in Head and Neck Squamous Cell Carcinoma. J Cancer. 10(17):4000-4008.

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