Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas

Liu, Qianqian; Li, Zhenzhen; Shang, Hao; Zhang, Qiaochu; Wang, Xiaomeng; Zhang, Yangyang; Wang, Yang; Li, Qianru; Li, Chunsen; Liu, Chunxia; Li, Feng

doi:10.7150/jca.31730

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J Cancer 2019; 10(18):4326-4332. doi:10.7150/jca.31730 This issue Cite

Research Paper

Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas

Qianqian Liu¹, Zhenzhen Li¹, Hao Shang¹, Qiaochu Zhang¹, Xiaomeng Wang¹, Yangyang Zhang¹, Yang Wang¹, Qianru Li¹, Chunsen Li¹, Chunxia Liu^1✉, Feng Li^1,2✉

1. Shihezi University, Shihezi 832002, Xinjiang, P.R. China. a. Department of Pathology, School of Medicine. b. The Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Chinese Ministry of Education. c. The First Affiliated Hospital, School of Medicine.
2. Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P. R. China.

Citation:

Liu Q, Li Z, Shang H, Zhang Q, Wang X, Zhang Y, Wang Y, Li Q, Li C, Liu C, Li F. Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas. J Cancer 2019; 10(18):4326-4332. doi:10.7150/jca.31730. https://www.jcancer.org/v10p4326.htm

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Abstract

Background: Soft tissue sarcomas include multiple histological subtypes and are highly aggressive. Moreover, SR-B1 is associated with malignant behavior and poor prognosis in a variety of cancers. However, there have been no attempts to assess whether SR-B1 expression in soft tissue sarcoma. We aimed to detect the expression levels of the SR-B1 protein in soft tissue sarcoma.

Methods: We assessed SR-B1 expression via immunohistochemistry and tissue microarrays in 107 soft tissue sarcomas with 4 phenotypes: 26 liposarcomas, 18 Ewing's sarcomas, 20 rhabdomyosarcomas and 43 leiomyosarcomas.

Results: Tumor cell SR-B1 expression was seen in 18/26 (69.2%) liposarcomas, 1/18 (5.55%) Ewing's sarcomas, 1/20 (5.00%) rhabdomyosarcomas, 2/43 (4.70%) leiomyosarcomas and was stained in the cell membrane. We found that SR-B1 expression in liposarcomas (18/26) was significantly higher than that in non-lipomatous sarcomas (4/77) (χ2 = 49.811, p = 0.000) and in well-differentiated liposarcoma (13/15) was significantly higher than that in dedifferentiated liposarcoma (5/11) (p = 0.038). No significant correlation was found between SR-B1 and gender, nationality, size and tumor location (p > 0.05), but it was significantly associated with ages (χ2 = 11.426, p = 0.001) and sarcoma phenotypes (χ2 = 49.817, p = 0.000).

Conclusion: Our findings highlight the highly expression of SR-B1 in liposarcomas. SR-B1 may be a potential biomarker for the diagnosis of liposarcoma and may indicate the degree of differentiation of liposarcomas.

Keywords: Scavenger receptor class B type 1, Immunohistochemistry, Tissue microarray, Liposarcoma, Biomarker

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APA

Liu, Q., Li, Z., Shang, H., Zhang, Q., Wang, X., Zhang, Y., Wang, Y., Li, Q., Li, C., Liu, C., Li, F. (2019). Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas. Journal of Cancer, 10(18), 4326-4332. https://doi.org/10.7150/jca.31730.

ACS

Liu, Q.; Li, Z.; Shang, H.; Zhang, Q.; Wang, X.; Zhang, Y.; Wang, Y.; Li, Q.; Li, C.; Liu, C.; Li, F. Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas. J. Cancer 2019, 10 (18), 4326-4332. DOI: 10.7150/jca.31730.

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CSE

Liu Q, Li Z, Shang H, Zhang Q, Wang X, Zhang Y, Wang Y, Li Q, Li C, Liu C, Li F. 2019. Scavenger Receptor Class B Type 1 (SR-B1) being a Potential Biomarker for the Diagnosis of Liposarcoma and Associated with the Degree of Differentiation of Liposarcomas. J Cancer. 10(18):4326-4332.

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