J Cancer 2019; 10(21):5162-5172. doi:10.7150/jca.36300

Review

Update on current pancreatic treatments: from molecular pathways to treatment

Konstantinos Sapalidis1, Christoforos Kosmidis1, Varvara Funtanidou2, Athanasios Katsaounis1, Amastasios Barmpas1, Georgios Koimtzis1, Stylianos Mantalobas1, Vyron Alexandrou1, Zoi Aidoni1, Charilaos Koulouris1, Efstathios Pavlidis1, Dimitrios Giannakidis1, Valeriu Surlin1, Stelian Pantea5, Victor Strambu6, Rogoveanu Otilia Constantina7, Aikaterini Amaniti2, Paul Zarogoulidis1,2✉, Stelian Mogoantă3, Isaak Kesisoglou1, Chrysanthi Sardeli4

1. 3rd Department of Surgery, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece
2. Anesthesiology Department, “AHEPA” University Hospital, Aristotle University of Thessaloniki, Medical School, Thessaloniki, Greece
3. Department of Pharmacology and Department of Surgery, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania
4. Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
5. Surgery Department, University of Timisoara, Romania
6. General Surgery Department, "Dr Carol Davila", University of Medicine and Pharmacy, Bucuresti, Romania
7. University of Medicine and Pharmacy, Craiova, Romania

Abstract

Pancreatic cancer is still diagnosed at a late stage although we have novel diagnostic tools. Pancreatic cancer chemotherapy treatment resistance is observed and therefore novel treatments are in need. Anti-cancer stem cell therapy, combination of chemotherapy and/or radiotherapy with immunotherapy, proteins/enzymes and gene therapy are currently under evaluation. Targeted treatment with tyrosine kinase inhibitors is also administered and novel inhibitors are also under evaluation. In the current review we present recent data from our search within the year 2018.

Keywords: pancreatic cancer, gene therapy, stem cells, cancer

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How to cite this article:
Sapalidis K, Kosmidis C, Funtanidou V, Katsaounis A, Barmpas A, Koimtzis G, Mantalobas S, Alexandrou V, Aidoni Z, Koulouris C, Pavlidis E, Giannakidis D, Surlin V, Pantea S, Strambu V, Constantina RO, Amaniti A, Zarogoulidis P, Mogoantă S, Kesisoglou I, Sardeli C. Update on current pancreatic treatments: from molecular pathways to treatment. J Cancer 2019; 10(21):5162-5172. doi:10.7150/jca.36300. Available from http://www.jcancer.org/v10p5162.htm