The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis

Guo, Yinghao; Liu, Jinqiang; Wang, Fei; Wang, Qiao; Zheng, Gaozan; Liu, Shushang; Lian, Xiao; Zhang, Hongwei; Feng, Fan

doi:10.7150/jca.30040

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J Cancer 2019; 10(23):5785-5792. doi:10.7150/jca.30040 This issue Cite

Research Paper

The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis

Yinghao Guo^1,2, Jinqiang Liu^1,3, Fei Wang^1,4, Qiao Wang^1,5, Gaozan Zheng¹, Shushang Liu¹, Xiao Lian¹, Hongwei Zhang^1✉, Fan Feng^1✉

1. Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, 127 West Changle Road, 710032, Xi'an, Shaanxi, China.
2. Health company, 92667 Army of PLA, 39 East Zaoshan Road, 266100, Qingdao, Shandong, China.
3. Cadre' s sanitarium, 62101 Army of PLA, 67 Nahu Road, 464000, Xinyang, Henan, China.
4. Department of General Surgery, No. 534 Hospital of PLA, West Lichun Road, 471000, Luoyang, Henan, China.
5. Department of General Surgery, No. 91 Hospital of PLA, 239 Gongye Road, 454000, Jiaozuo, Henan, China.

✉ Corresponding author: Hongwei Zhang, PhD, Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University, 127 West Changle Road, 710032, Xi'an, Shaanxi, China. Tel: +86-029-84771531. Fax: +86-029-84771 More

Citation:

Guo Y, Liu J, Wang F, Wang Q, Zheng G, Liu S, Lian X, Zhang H, Feng F. The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis. J Cancer 2019; 10(23):5785-5792. doi:10.7150/jca.30040. https://www.jcancer.org/v10p5785.htm

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Abstract

Background The benefit of surgical resection for advanced gastrointestinal stromal tumors (GISTs) following tyrosine kinase inhibitors (TKIs) treatment was still under debate. The present meta-analysis was designed to assess the value of surgical resection for the prognosis of patients with metastatic, recurrence and unresectable GISTs. Methods A systematic search of PubMed Central, PubMed, EMBASE and the Cochrane Library database was performed. Relevant studies of the role of surgery in advanced GISTs published before 1 May 2019 were identified. The quality of studies was assessed by the Newcastle-Ottawa Quality Assessment Scale. The progression-free survival (PFS) and overall survival (OS) were assessed through software Stata 15.0. Results A total of 6 retrospective studies including 655 patients were analyzed. The pooled result revealed that surgical resection group was associated with better PFS (HR = 2.08; 95% CI: 1.58 to 2.76; P<0.001) and better OS (HR = 2.13; 95% CI: 1.59 to 2.85; P<0.001) compared with TKIs treatment alone group. Conclusions Surgical resection following TKIs treatment could significantly improve the prognosis of patients with advanced GISTs.

Keywords: Gastrointestinal stromal tumor, Tyrosine kinase inhibitor, Surgery, Meta-analysis

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APA

Guo, Y., Liu, J., Wang, F., Wang, Q., Zheng, G., Liu, S., Lian, X., Zhang, H., Feng, F. (2019). The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis. Journal of Cancer, 10(23), 5785-5792. https://doi.org/10.7150/jca.30040.

ACS

Guo, Y.; Liu, J.; Wang, F.; Wang, Q.; Zheng, G.; Liu, S.; Lian, X.; Zhang, H.; Feng, F. The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis. J. Cancer 2019, 10 (23), 5785-5792. DOI: 10.7150/jca.30040.

NLM

CSE

Guo Y, Liu J, Wang F, Wang Q, Zheng G, Liu S, Lian X, Zhang H, Feng F. 2019. The Role of Surgical Resection Following Tyrosine Kinase Inhibitors Treatment in Patients with Advanced Gastrointestinal Stromal Tumors: A Systematic Review and Meta-analysis. J Cancer. 10(23):5785-5792.

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