Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis

Zhou, Linghui; Yang, Pengtao; Zheng, Yi; Tian, Tian; Dai, Cong; Wang, Meng; Lin, Shuai; Deng, Yujiao; Hao, Qian; Zhai, Zhen; Li, Hongtao; Dai, Zhijun

doi:10.7150/jca.35204

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J Cancer 2019; 10(25):6225-6232. doi:10.7150/jca.35204 This issue Cite

Research Paper

Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis

Linghui Zhou^1,2*, Pengtao Yang^2*, Yi Zheng^1*, Tian Tian^1,2, Cong Dai¹, Meng Wang², Shuai Lin², Yujiao Deng^1,2, Qian Hao^1,2, Zhen Zhai^1,2, Hongtao Li^3✉, Zhijun Dai^1✉

1. Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.
2. Department of Oncology, The 2nd Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.
3. Department of Breast Head and Neck surgery, The 3rd Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Tumor Hospital), Urumqi 830000, Xinjiang, China.
* LH Z, PT Y and Y Z contributed equally to this work.

Citation:

Zhou L, Yang P, Zheng Y, Tian T, Dai C, Wang M, Lin S, Deng Y, Hao Q, Zhai Z, Li H, Dai Z. Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis. J Cancer 2019; 10(25):6225-6232. doi:10.7150/jca.35204. https://www.jcancer.org/v10p6225.htm

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Abstract

Background: Currently, there is still some controversy regarding whether early breast cancer patients with a tumor size of ≤5 cm and 1-3 positive lymph nodes should undergo postoperative radiotherapy (PRT).

Materials and Methods: We obtained data from the Surveillance, Epidemiology, and End Results (SEER) 18 database. Then, we conducted propensity score matching (PSM), according to the radiotherapy record. The Kaplan-Meier and Cox regression analysis were conducted to explore prognostic factors in breast cancer.

Results: A total of 6,777 patients aged 75+ years old were eligible and 2,361 patients were included after PSM. We found PRT could improve patient overall survival (OS) (P = 0.01, hazard ratio [HR] = 0.88, 95% confidence interval [CI], 0.80-0.97). Subgroup analysis revealed PRT could improve OS in patients with hormone receptor positive (HR+) (P = 0.001, HR = 0.84, 95% CI, 0.76 - 0.94) or white patients (P =0.004, HR = 0.86, 95% CI, 0.77 - 0.95).

Conclusions: PRT may benefit for elderly women with early breast cancer, especially in HR+ patients or white patients. These findings may inform future optimized options whether elderly female patients with early breast cancer should undergo postoperative radiotherapy.

Keywords: postoperative radiotherapy, early breast cancer, seer database, propensity score matching, prognosis

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APA

Zhou, L., Yang, P., Zheng, Y., Tian, T., Dai, C., Wang, M., Lin, S., Deng, Y., Hao, Q., Zhai, Z., Li, H., Dai, Z. (2019). Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis. Journal of Cancer, 10(25), 6225-6232. https://doi.org/10.7150/jca.35204.

ACS

Zhou, L.; Yang, P.; Zheng, Y.; Tian, T.; Dai, C.; Wang, M.; Lin, S.; Deng, Y.; Hao, Q.; Zhai, Z.; Li, H.; Dai, Z. Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis. J. Cancer 2019, 10 (25), 6225-6232. DOI: 10.7150/jca.35204.

NLM

CSE

Zhou L, Yang P, Zheng Y, Tian T, Dai C, Wang M, Lin S, Deng Y, Hao Q, Zhai Z, Li H, Dai Z. 2019. Effects of Postoperative Radiotherapy in Early Breast Cancer Patients Older than 75 Years: A Propensity-Matched Analysis. J Cancer. 10(25):6225-6232.

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