ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2022; 13(4):1241-1251. doi:10.7150/jca.62652 This issue Cite
Research Paper
miR-497-5p-RSPO2 axis inhibits cell growth and metastasis in glioblastoma
1. School of Medicine, Liaocheng University, Shandong, 252000, China.
2. Institute for Tissue Engineering and Regenerative Medicine, Liaocheng University/Liaocheng People's Hospital, Shandong, 252000, China.
3. Department of Gastroenterology, The Second People's Hospital of Nanyang, Henan, 473000, China.
4. Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Hubei, 430081, China.
*These authors contributed equally to this work.
Abstract
Numerous studies have found a relationship between cancer formation and aberrant microRNA expression, however the biological significance of miR-497-5p in glioblastoma (GBM) is still unknown. Compared to normal brain glial cells, miR-497-5p expression in GBM tissues was substantially lower in our study. The microRNA miR-497-5p targets R-spondin 2 (RSPO2) only when it is present. RSPO2 silencing has the same effect on GBM cells as miR-497-5p silencing, as demonstrated before. Additional mechanistic investigations have shown that miR-497-5p suppresses the Wnt/β-catenin signaling pathway by targeting RSPO2 to reduce cell proliferation, migration, and invasion. A negative correlation was discovered between MiR-497-5p and RSPO2 in 37 of the GBM tumors studied. MiR-497-5p-RSPO2 axis controls Wnt/β-catenin signaling and plays a function in GBM carcinogenesis, suggesting that it may be a therapeutic target to reduce GBM growth, as shown by our research findings.
Keywords: miR-497-5p, RSPO2, Oncogenesis, The Wnt/β-catenin pathway, GBM
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