ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2023; 14(13):2529-2537. doi:10.7150/jca.86678 This issue Cite
Research Paper
Impact of LINC00673 genetic variants on uterine cervical cancer clinicopathologic characteristics
1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. Department of Obstetrics and Gynecology, Chi-Mei Foundation Medical Center, Tainan, Taiwan
3. School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
4. Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
5. Department of Obstetrics and Gynecology, Chiayi Chang Gung Memorial Hospital Chiayi, Taiwan
6. Department of Nursing, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan
7. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
8. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
10. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
#Equal contribution as first authors
Abstract
To date, no study delineates the relationships among the genetic variants of long intergenic noncoding RNA 673 (LINC00673) and uterine cervical carcinogenesis as well as clinicopathological parameters and 5 years survival of cervical cancer patients in Taiwan. Therefore, the involvement of LINC00673 polymorphisms in cervical cancer was investigated. Genotypic frequencies of three LINC00673 polymorphisms rs6501551, rs9914618 and rs11655237 were determined in 199 patients including 115 patients with invasive cancer, 84 with precancerous lesions, and 274 control females using real-time polymerase chain reaction. It revealed that LINC00673 polymorphisms were not found significantly related to development of cervical cancer. Cervical cancer patients with genotypes AG/GG in LINC00673 rs6501551 had more risk to have tumor diameter larger than 4 cm as compared to those with genotype AA (p=0.043). Cervical cancer patients with genotype GG in rs6501551 had worse 5 years survival as compared to those with genotypes AA/AG in multivariate analysis (hazard ratio: 4.70; p=0.097). However, only two patients exhibiting GG were noted, and one had mortality, another had no mortality. In conclusion, larger sample size needs to verify the associations of LINC00673 genetic variants with clinicopathological parameters and patient survival of cervical cancer for Taiwanese females.
Keywords: long intergenic noncoding RNA 673, genetic variants, cervical carcinogenesis, clincopathological parameters, 5 years survival
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