ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2023; 14(14):2707-2719. doi:10.7150/jca.86996 This issue Cite
Review
The Dual Effects of Exosomes on Glioma: A Comprehensive Review
1. Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
2. Department of Neurosurgery, the Affiliated Hospital of PanZhiHua University, PanZhiHua 617000, China.
3. Southwest Medical University, Luzhou 646000, China.
4. Sichuan Clinical Research Center for Neurosurgery, Luzhou 646000, China.
5. Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China.
*Maowen Luo and Xingzhao Luan contributed equally to this work.
Abstract
Glioma is a frequently occurring type of cancer that affects the central nervous system. Despite the availability of standardized treatment options including surgical resection, concurrent radiotherapy, and adjuvant temozolomide (TMZ) therapy, the prognosis for glioma patients is often unfavorable. Exosomes act as vehicles for intercellular communication, contributing to tissue repair, immune modulation, and the transfer of metabolic cargo to recipient cells. However, the transmission of abnormal substances can also contribute to pathologic states such as cancer, metabolic diseases, and neurodegenerative disorders. The field of exosome research in oncology has seen significant advancements, with exosomes identified as dynamic modulators of tumor cell proliferation, migration, and invasion, as well as angiogenesis and drug resistance. Exosomes have negligible cytotoxicity, low immunogenicity, and small size, rendering them an ideal therapeutic candidate for glioma. This comprehensive review discusses the dual effects of exosomes in glioma, with an emphasis on their role in facilitating drug resistance. Furthermore, the clinical applications and current limitations of exosomes in glioma therapy are also discussed in detail.
Keywords: Glioma, exosome, diagnosis, therapy, drug resistance.
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