HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1

Li, Fang; Wang, Li; Wang, Yujue; Shen, Hui; Kou, Qianrui; Shen, Changjun; Xu, Xiangrong; Zhang, Yunqing; Zhang, Jing

doi:10.7150/jca.87545



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2023; 14(15):2820-2832. doi:10.7150/jca.87545 This issue Cite

Research Paper

HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1

Fang Li^1,†, Li Wang^1,†, Yujue Wang¹, Hui Shen¹, Qianrui Kou¹, Changjun Shen³, Xiangrong Xu¹, Yunqing Zhang^2,✉, Jing Zhang^1,✉

1. Medical School of Yan'an University, Yan'an 716000, China.
2. Yan'an University Affiliated Hospital, Yan'an 716000, China.
3. Yan'an People's Hospital, Yan'an 716000, China.
^†These authors contributed equally to this work.

Citation:

Li F, Wang L, Wang Y, Shen H, Kou Q, Shen C, Xu X, Zhang Y, Zhang J. HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1. J Cancer 2023; 14(15):2820-2832. doi:10.7150/jca.87545. https://www.jcancer.org/v14p2820.htm

Other styles

Abstract

Colorectal cancer (CRC) is among the most common malignancies worldwide. Although a recent study has shown that E3 ubiquitin ligases play a major role in regulating the occurrence and development of CRC, there are few reports on the role of the E3 ubiquitin ligase HECW2(HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2) in CRC progression and chemoresistance. We found that HECW2 is highly expressed in CRC tissues. HECW2 knockdown inhibits CRC progression and chemoresistance, whereas HECW2 overexpression has the opposite effect. Mechanistically, HECW2 activates the AKT/mTOR signaling pathway by mediating the ubiquitin-proteasome degradation of lamin B1, thereby promoting CRC progression and chemoresistance. Our findings suggest that HECW2 may be a promising novel therapeutic target for CRC treatment.

Keywords: colorectal cancer, progression, chemoresistance, HECW2, lamin B1, AKT/mTOR signaling pathway

Citation styles

APA

Li, F., Wang, L., Wang, Y., Shen, H., Kou, Q., Shen, C., Xu, X., Zhang, Y., Zhang, J. (2023). HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1. Journal of Cancer, 14(15), 2820-2832. https://doi.org/10.7150/jca.87545.

ACS

Li, F.; Wang, L.; Wang, Y.; Shen, H.; Kou, Q.; Shen, C.; Xu, X.; Zhang, Y.; Zhang, J. HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1. J. Cancer 2023, 14 (15), 2820-2832. DOI: 10.7150/jca.87545.

NLM

CSE

Li F, Wang L, Wang Y, Shen H, Kou Q, Shen C, Xu X, Zhang Y, Zhang J. 2023. HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1. J Cancer. 14(15):2820-2832.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.