J Cancer
2023; 14(16):3023-3027.
doi:10.7150/jca.87128 This issueCite
Research Paper
Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients
Zuhair M. Mohammedsaleh1,✉, Mamdoh S. Moawadh1, Fayez M. Saleh2, Mohammed M. Jalal1, Abdulaziz S Al-Otaibi1, Nizar H. Saeedi1, Rathinasamy Baskaran3, Chih-Yang Huang4, V. Bharath Kumar5
1. Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia. 2. Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia. 3. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. 4. Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. 5. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 413, Taiwan.
✉ Corresponding author: Zuhair M. Mohammedsaleh, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia. Email: zsalehedu.sa (Z.M.M.).
Citation:
Mohammedsaleh ZM, Moawadh MS, Saleh FM, Jalal MM, Al-Otaibi AS, Saeedi NH, Baskaran R, Huang CY, Kumar VB. Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients. J Cancer 2023; 14(16):3023-3027. doi:10.7150/jca.87128. https://www.jcancer.org/v14p3023.htm
Notch deregulation has been reported in various types of cancers, including Oral squamous cell carcinomas (OSCCs). The role of Notch1 signaling in oral squamous cell carcinoma (OSCC) remains poorly understood. In this study, NOTCH1 was aberrantly expressed in human oral cancer tissues compared with that in normal marginal tissues and was associated with poor prognosis. The positive Notch 1 expression was significantly associated with poor tumor differentiation status. Kaplan-Meier survival curves revealed that elevated cytoplasmic NOTCH1 expression levels in OSCC patients were associated with poor overall survival. Moreover, multivariate COX proportional hazard models revealed that T N status, AJCC stage histological grade were independent prognostic factors for survival. Our result clearly demonstrates the oncogenic role of Notch1 in oral cancer and Notch1 may be a useful biomarker to target oral cancer patients.
Mohammedsaleh, Z.M., Moawadh, M.S., Saleh, F.M., Jalal, M.M., Al-Otaibi, A.S., Saeedi, N.H., Baskaran, R., Huang, C.Y., Kumar, V.B. (2023). Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients. Journal of Cancer, 14(16), 3023-3027. https://doi.org/10.7150/jca.87128.
ACS
Mohammedsaleh, Z.M.; Moawadh, M.S.; Saleh, F.M.; Jalal, M.M.; Al-Otaibi, A.S.; Saeedi, N.H.; Baskaran, R.; Huang, C.Y.; Kumar, V.B. Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients. J. Cancer 2023, 14 (16), 3023-3027. DOI: 10.7150/jca.87128.
NLM
Mohammedsaleh ZM, Moawadh MS, Saleh FM, Jalal MM, Al-Otaibi AS, Saeedi NH, Baskaran R, Huang CY, Kumar VB. Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients. J Cancer 2023; 14(16):3023-3027. doi:10.7150/jca.87128. https://www.jcancer.org/v14p3023.htm
CSE
Mohammedsaleh ZM, Moawadh MS, Saleh FM, Jalal MM, Al-Otaibi AS, Saeedi NH, Baskaran R, Huang CY, Kumar VB. 2023. Increased NOTCH1 expression is associated with low survival in moderate/ poor differentiated human oral squamous cell carcinoma patients. J Cancer. 14(16):3023-3027.
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