Survival effects of postoperative adjuvant TACE in early-HCC patients with microvascular invasion: A multicenter propensity score matching

Qian, Junlin; Shen, Yanling; Cui, Lifeng; Wu, Zhao; Tu, Shuju; Lin, Wei; Tang, Hongtao; Hu, Zemin; Liu, Liping; Shen, Wei; He, Yongzhu; He, Kun

doi:10.7150/jca.87435

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J Cancer 2024; 15(1):68-78. doi:10.7150/jca.87435 This issue Cite

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Survival effects of postoperative adjuvant TACE in early-HCC patients with microvascular invasion: A multicenter propensity score matching

Junlin Qian^1*, Yanling Shen^1*, Lifeng Cui^3,5*, Zhao Wu^4*, Shuju Tu², Wei Lin¹, Hongtao Tang¹, Zemin Hu¹, Liping Liu³, Wei Shen⁴, Yongzhu He^2✉, Kun He^1✉

1. Department of Hepatobiliary Surgery, Zhongshan People's Hospital (Zhongshan Hospital Affiliated to Sun Yat-sen University), Zhongshan City, Guangdong Province, China 528400.
2. Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery, The First Affiliated Hospital of Nanchang University (The First Clinical Medical College of Nanchang University), Nanchang City, Jiangxi Province, China 330006.
3. Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen City, Guangdong Province, China 518020.
4. Department of General Surgery, The Second Affiliated Hospital of Nanchang University (The Second Clinical Medical College of Nanchang University), Nanchang City, Jiangxi Province, China 330006.
5. Maoming People's Hospital, Maoming City, Guangdong Province, China 525000.
*Authors contributed equally to this work.

✉ Corresponding authors: Kun He, MD, PhD. Department of Hepatobiliary Surgery, Zhongshan People's Hospital (Zhongshan Hospital Affiliated to Sun Yat-sen University), No. 2, Sunwen East Road, Shiqi District, Zhongshan City, Guangdong Province,China 528 More

Citation:

Qian J, Shen Y, Cui L, Wu Z, Tu S, Lin W, Tang H, Hu Z, Liu L, Shen W, He Y, He K. Survival effects of postoperative adjuvant TACE in early-HCC patients with microvascular invasion: A multicenter propensity score matching. J Cancer 2024; 15(1):68-78. doi:10.7150/jca.87435. https://www.jcancer.org/v15p0068.htm

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Abstract

Background: The presence of microvascular invasion (MVI) significantly worsens the surgical outcome of hepatocellular carcinoma (HCC). The purpose of this research was to investigate the survival benefit of adjuvant transarterial chemoembolization (TACE) in patients with MVI after hepatectomy.

Methods: A retrospective analysis was conducted on 1372 HCC patients who underwent curative liver resection in four medical institutions. In order to minimize confounding factors and selection bias between groups, Propensity Score Matching (PSM) (1:1) was performed to ensure balanced clinical characteristics.

Results: A total of 1056 patients were enrolled after PSM, including 672 patients with MVI and 384 patients without MVI. Adjuvant TACE improves DFS (Median, 36 months vs 14 months, p < 0.001) and OS (Median, NA vs 32 months, p < 0.001) in patients harboring MVI, but not in those (all p > 0.05) lacking MVI. In different different CNLC stages, adjuvant TACE improved DFS (CNLC stage I, Median, 37 vs 15 months; CNLC stage II, Median, 25 vs 11 months, p < 0.001) and OS (CNLC stage I, Median, NA vs 32 months, p < 0.001; CNLC stage II, Median, NA vs 26 months, p = 0.002) in patients who carried MVI, but not in those (CNLC stage I-II, all p > 0.05) who lacked MVI.

Conclusions: Adjuvant TACE may be a potentially effective treatment option for improving survival outcomes in early-HCC patients harboring MVI, but not in those lacking MVI.

Keywords: Microvascular invasion, Hepatocellular Carcinoma, Transarterial chemoembolization, Hepatectomy

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APA

Qian, J., Shen, Y., Cui, L., Wu, Z., Tu, S., Lin, W., Tang, H., Hu, Z., Liu, L., Shen, W., He, Y., He, K. (2024). Survival effects of postoperative adjuvant TACE in early-HCC patients with microvascular invasion: A multicenter propensity score matching. Journal of Cancer, 15(1), 68-78. https://doi.org/10.7150/jca.87435.

ACS

Qian, J.; Shen, Y.; Cui, L.; Wu, Z.; Tu, S.; Lin, W.; Tang, H.; Hu, Z.; Liu, L.; Shen, W.; He, Y.; He, K. Survival effects of postoperative adjuvant TACE in early-HCC patients with microvascular invasion: A multicenter propensity score matching. J. Cancer 2024, 15 (1), 68-78. DOI: 10.7150/jca.87435.

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CSE

Qian J, Shen Y, Cui L, Wu Z, Tu S, Lin W, Tang H, Hu Z, Liu L, Shen W, He Y, He K. 2024. Survival effects of postoperative adjuvant TACE in early-HCC patients with microvascular invasion: A multicenter propensity score matching. J Cancer. 15(1):68-78.

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