Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma

Song, Congkuan; Song, Yaolin; Wan, Xiaoxia; Zhao, Zhihong; Geng, Qing

doi:10.7150/jca.88777

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J Cancer 2024; 15(1):218-231. doi:10.7150/jca.88777 This issue Cite

Research Paper

Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma

Congkuan Song^1#, Yaolin Song^2#, Xiaoxia Wan^2#, Zhihong Zhao², Qing Geng^1✉

1. Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
2. Department of Thoracic Surgery, Ezhou Central Hospital, Ezhou, China.
^# These authors contributed equally to this work.

Citation:

Song C, Song Y, Wan X, Zhao Z, Geng Q. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J Cancer 2024; 15(1):218-231. doi:10.7150/jca.88777. https://www.jcancer.org/v15p0218.htm

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Abstract

Histone H3-H4 chaperone anti-silencing function 1 (ASF1) plays an important role in the polymerization, transport, and modification of histones. However, the significance of ASF1B in lung adenocarcinoma (LUAD) is largely overlooked. We investigated the aberrant expression of ASF1B in LUAD and its potential link to patient survival using multiple databases. ASF1B-overexpressing and knockdown cell lines were constructed to explore its effects on the biological behavior of lung cancer cells. ssGSEA, TMB, TIDE and IMvigor210 cohort were used to explore and validate the association of ASF1B to tumor immunity. Our data suggested that ASF1B was overexpressed in LUAD, and was associated with poor prognosis. ASF1B promoted the proliferation, migration, and invasion of lung cancer cells by regulating the phosphorylation of AKT in vitro. ASF1B was associated with tumor immunity. In summary, ASF1B may promote malignant behavior of LUAD cells, and its overexpression correlates with worse prognosis and better immunotherapy effect.

Keywords: Anti-silencing function 1B (ASF1B), lung adenocarcinoma (LUAD), prognosis, immunotherapy, biomarker.

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APA

Song, C., Song, Y., Wan, X., Zhao, Z., Geng, Q. (2024). Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. Journal of Cancer, 15(1), 218-231. https://doi.org/10.7150/jca.88777.

ACS

Song, C.; Song, Y.; Wan, X.; Zhao, Z.; Geng, Q. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J. Cancer 2024, 15 (1), 218-231. DOI: 10.7150/jca.88777.

NLM

CSE

Song C, Song Y, Wan X, Zhao Z, Geng Q. 2024. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J Cancer. 15(1):218-231.

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