Chronic Obstructive Pulmonary Disease and Non-Small Cell Lung Cancer an association

Zarogoulidis, Paul; Oikonomidou, Rena; Petridis, Dimitris; Huang, Haidong; Bai, Chong; perdokouri, Eleni-Isidora; Vagionas, Anastasios; Hohenforst-Schmidt, Wolfgang; Kosmidis, Christoforos; Sapalidis, Konstantinos; Oikonomou, Panagoula; Nikolaou, Christina; Charalampidis, Charalampos; Matthaios, Dimitrios; Pataka, Athanasia; Sardeli, Chrysanthi

doi:10.7150/jca.90594

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J Cancer 2024; 15(3):603-609. doi:10.7150/jca.90594 This issue Cite

Research Paper

Chronic Obstructive Pulmonary Disease and Non-Small Cell Lung Cancer an association

Paul Zarogoulidis^1,2✉, Rena Oikonomidou³, Dimitris Petridis⁴, Haidong Huang⁵, Chong Bai⁴, Eleni-Isidora perdokouri⁶, Anastasios Vagionas⁷, Wolfgang Hohenforst-Schmidt⁸, Christoforos Kosmidis¹, Konstantinos Sapalidis¹, Panagoula Oikonomou⁹, Christina Nikolaou⁹, Charalampos Charalampidis¹⁰, Dimitrios Matthaios¹¹, Athanasia Pataka¹², Chrysanthi Sardeli¹³

1. 3 rd University General Hospital, ``AHEPA`` University Hospital, Thessaloniki, Greece.
2. Pulmonary Department, General Clinic Euromedica, Thessaloniki, Greece.
3. Health Center of Evosmos, Thessaloniki, Greece.
4. Department of Food Science and Technology International Hellenic University, Alexander Campus, Sindos, Thessaloniki.
5. Department of Respiratory & Critical Care Medicine, Changhai Hospital, the Second Military Medical University, Shanghai, P. R. China.
6. Oncology Deprtment, General Hospital of Volos, Greece.
7. Oncology Department (NHS), General Hospital of Kavala, Kavala, Greece.
8. Sana Clinic Group Franken, Department of Cardiology / Pulmonology / Intensive Care / Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.
9. Second Department of Surgery, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
10. Pathology Department, University of Cyprus, Cyprus.
11. Oncology Department, General Hospital of Rhodos, Rhodos, Greece.
12. Pulmonary Department, G.Papnikolaou General Hospital, Aristotle University of Thessaloniki, Greece.
13. Department of Pharmacology & Clinical Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Citation:

Zarogoulidis P, Oikonomidou R, Petridis D, Huang H, Bai C, perdokouri EI, Vagionas A, Hohenforst-Schmidt W, Kosmidis C, Sapalidis K, Oikonomou P, Nikolaou C, Charalampidis C, Matthaios D, Pataka A, Sardeli C. Chronic Obstructive Pulmonary Disease and Non-Small Cell Lung Cancer an association. J Cancer 2024; 15(3):603-609. doi:10.7150/jca.90594. https://www.jcancer.org/v15p0603.htm

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Abstract

Objectives: Lung cancer is known to be associated with chronic obstructive pulmonary disease. Moreover; nutritional status is associated with chronic obstructive disease treatment and lung cancer. Our aim was to evaluate the interaction of the COPD status and treatment of non-small cell lung cancer.

Methods: Eighty-two patients were enrolled in our multicenter study. Chronic obstructive disease stage, spirometry and treatment was recorded along with the treatment and Body Mass Index (BMI), Mediterranian Diet Score, Pack Years, Basic Metabolsim (RMR) (kcal/day), VO₂ (ml/min), Ve (lt/min) and Physical Activity. The statistical analysis was performed using the JMP 14.3 (SAS Inc 2018) software.

Results: The drug pairs showed a steady and unchanged by time health condition for 48 patients. Overall, 31 patients were recorded with worse COPD health conditions. The one-way ANOVA clearly indicated that chemotherapy induced the best FEV₁-difference conditions with a positive effect of 8.56 mean FEV volume, the combined treatment simply did not have an effect (-0.9), while immunotherapy and patients receiving radiation decreased their FEV₁ volume down to -4.23 and -5.15 mean values.

Conclusions: Patients receiving chemotherapy alone had their chronic obstructive disease improved with less drugs and exacerbations, while patients receiving immunotherapy had their chronic obstructive disease stable, while all other treatment combinations worsened the patients chronic obstructive disease. Nutritional status did not affect the chronic obstructive disease of these patients in any way.

Keywords: COPD, Nutrition, NSCLC, spirometry, DLCO

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APA

Zarogoulidis, P., Oikonomidou, R., Petridis, D., Huang, H., Bai, C., perdokouri, E.I., Vagionas, A., Hohenforst-Schmidt, W., Kosmidis, C., Sapalidis, K., Oikonomou, P., Nikolaou, C., Charalampidis, C., Matthaios, D., Pataka, A., Sardeli, C. (2024). Chronic Obstructive Pulmonary Disease and Non-Small Cell Lung Cancer an association. Journal of Cancer, 15(3), 603-609. https://doi.org/10.7150/jca.90594.

ACS

Zarogoulidis, P.; Oikonomidou, R.; Petridis, D.; Huang, H.; Bai, C.; perdokouri, E.I.; Vagionas, A.; Hohenforst-Schmidt, W.; Kosmidis, C.; Sapalidis, K.; Oikonomou, P.; Nikolaou, C.; Charalampidis, C.; Matthaios, D.; Pataka, A.; Sardeli, C. Chronic Obstructive Pulmonary Disease and Non-Small Cell Lung Cancer an association. J. Cancer 2024, 15 (3), 603-609. DOI: 10.7150/jca.90594.

NLM

CSE

Zarogoulidis P, Oikonomidou R, Petridis D, Huang H, Bai C, perdokouri EI, Vagionas A, Hohenforst-Schmidt W, Kosmidis C, Sapalidis K, Oikonomou P, Nikolaou C, Charalampidis C, Matthaios D, Pataka A, Sardeli C. 2024. Chronic Obstructive Pulmonary Disease and Non-Small Cell Lung Cancer an association. J Cancer. 15(3):603-609.

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