Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3

Lee, Kristi Y.; Beatson, Erica L.; Knechel, Martina A.; Sommer, Elijah R.; Napoli, Giulia C.; Risdon, Emily N.; Leon, Andres F.; Depaz, Roger D.; Strope, Jonathan D.; Price, Douglas K.; Chau, Cindy H.; Figg, William D.

doi:10.7150/jca.90836

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J Cancer 2024; 15(3):615-622. doi:10.7150/jca.90836 This issue Cite

Research Paper

Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3

Kristi Y. Lee^1,†, Erica L. Beatson^1,†, Martina A. Knechel¹, Elijah R. Sommer¹, Giulia C. Napoli¹, Emily N. Risdon¹, Andres F. Leon¹, Roger D. Depaz², Jonathan D. Strope², Douglas K. Price¹, Cindy H. Chau¹, William D. Figg^1,2,✉

1. Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
2. Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
†Co-first authors.

Citation:

Lee KY, Beatson EL, Knechel MA, Sommer ER, Napoli GC, Risdon EN, Leon AF, Depaz RD, Strope JD, Price DK, Chau CH, Figg WD. Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3. J Cancer 2024; 15(3):615-622. doi:10.7150/jca.90836. https://www.jcancer.org/v15p0615.htm

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Abstract

Extracellular vesicles (EVs) provide a minimally invasive liquid biopsy source of tumor-specific markers for patients who have already undergone prostatectomies. Our laboratory has previously demonstrated enrichment of the cancer-type solute carrier organic anion transporter family 1B3 (ct-SLCO1B3) and the ATP Binding Cassette Subfamily Member C (ABCC3) in castration-resistant cell lines (CRPC). However, their expression in EVs has yet to be explored. Our study demonstrated that ct-SLCO1B3 and ABCC3 are highly detectable in CRPC cell line-derived EVs. We also showed that ct-SLCO1B3 and ABCC3 were detectable in a CRPC xenograft mouse model, both intratumorally and in plasma-derived EVs. Our results provide evidence for EV-contained ct-SLCO1B3 and ABCC3 as novel, EV-based tumor markers for prostate cancer progression.

Keywords: organic anion transporter family 1B3, SLCO1B3, ABCC3, prostate cancer, extracellular vesicle, cancer biomarker

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APA

Lee, K.Y., Beatson, E.L., Knechel, M.A., Sommer, E.R., Napoli, G.C., Risdon, E.N., Leon, A.F., Depaz, R.D., Strope, J.D., Price, D.K., Chau, C.H., Figg, W.D. (2024). Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3. Journal of Cancer, 15(3), 615-622. https://doi.org/10.7150/jca.90836.

ACS

Lee, K.Y.; Beatson, E.L.; Knechel, M.A.; Sommer, E.R.; Napoli, G.C.; Risdon, E.N.; Leon, A.F.; Depaz, R.D.; Strope, J.D.; Price, D.K.; Chau, C.H.; Figg, W.D. Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3. J. Cancer 2024, 15 (3), 615-622. DOI: 10.7150/jca.90836.

NLM

CSE

Lee KY, Beatson EL, Knechel MA, Sommer ER, Napoli GC, Risdon EN, Leon AF, Depaz RD, Strope JD, Price DK, Chau CH, Figg WD. 2024. Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3. J Cancer. 15(3):615-622.

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