ISSN: 1837-9664Journal of Cancer
Global reach, higher impact
J Cancer 2024; 15(3):671-684. doi:10.7150/jca.88783 This issue Cite
Research Paper
Ginsenosides and Tumors: A Comprehensive and Visualized Analysis of Research Hotspots and Antitumor Mechanisms
1. Department of Pharmacy, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
2. Department of Clinical Medicine, Hainan Health Vocational College, Hainan 572000, China.
3. Department of Clinical Laboratory. Naval Hospital of Eastern Theater of PLA, Zhoushan, Zhejiang Province 316000, China.
4. Department of Gastroenterology, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan 610031, China.
5. School of Medicine, Shanghai University, Shanghai 200444, China.
* These authors contributed equally to this work.
Abstract
Background: Ginsenoside, the main active constituent of traditional Chinese medicine Ginseng, has been shown to play an important role in the prevention and treatment of cancer. However, the literature as well as the antitumor mechanisms of ginsenosides has not yet been systematically studied.
Methods: We screened all relevant literature on ginsenosides and tumors from Web of Science during 2001-2021 and analyzed the extracted terms of these publications by VOSviewer and CiteSpace. DAVID online tool was used to perform Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathways analysis of ginsenoside-related genes. Cytoscape and String software were used to construct the interaction networks of ginsenoside-related genes and corresponding proteins.
Results: A total of 919 publications were included in the study. A total of 122 identified keywords were mainly divided into 3 clusters: “pharmacological function research”, “functional validation in animal models” and “anti-tumor efficacy and mechanism”. The keywords of “oxidative stress” had the strongest citation burst in the past 5 years. A total of 50 genes were identified as ginsenoside-related genes in tumors. They have the function of regulating gene expression and apoptosis, and they are closely related to signaling pathways in cancers. Ginsenoside-related genes form a complex interactional network, in which TP53 and IL-6 are centrally located.
Conclusions: We explored and revealed research hotspots related to the ginsenosides and tumors. More precise anti-tumor mechanism research will be promising in the future. TP53 and IL-6 may be the key points to comprehending the anti-tumor mechanism of ginsenosides.
Keywords: bibliometrics, chemotherapy, ginsenoside, hotspots, tumor.
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