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J Cancer 2024; 15(5):1182-1190. doi:10.7150/jca.91048 This issue Cite

Research Paper

DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders

Huan Li1,*, Wenhui Li1,*, Yijun Gao1, Junqi Li2, Xiliang Zeng2, Jiaming Lin1, Xiaoyan Xie1✉, Tianyou Ling1✉

1. Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China.
2. Changsha JianLu Medical Laboratory Co, 18 Luyun Road, Changsha 410006, People's Republic of China.
* Huan Li and Wenhui Li should be considered joint first author

✉ Corresponding authors: Tianyou Ling, Department of Stomatology, The Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha 410011, People's Republic of China; Email: 772660166com. Xiaoyan Xie, Department of Stomatolo More

Citation:
Li H, Li W, Gao Y, Li J, Zeng X, Lin J, Xie X, Ling T. DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders. J Cancer 2024; 15(5):1182-1190. doi:10.7150/jca.91048. https://www.jcancer.org/v15p1182.htm
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Abstract

Graphic abstract

Background: Oral Submucosal Fibrosis (OSF) and Oral Leukoplakia (OLK) are well-known oral potentially malignant disorders, and cases of Oral Submucosal Fibrosis concomitant Oral Leukoplakia (OSF+OLK) are now being reported clinically. DNA image cytometry is an objective and non-invasive method for monitoring the risk of precancerous lesions in the oral cavity.

Methods: A total of 111 patients with clinically characterized oral mucosal lesions underwent simultaneous and independent histopathological and DNA imaging cytometry assessments. Clinical data were also collected for each patient.

Results: The frequency of DNA content abnormality was higher in the tongue than in other oral sites (P = 0.003) for OLK. The frequency of DNA content abnormality was higher in the tongue than in other oral sites (P = 0.035) for OSF+OLK. The differences of DNA content abnormality in age, sex, dietary habit, smoking, and alcohol intake were not observed in OLK and OSF+OLK. The study indicates an association between DNA content abnormality and pathological examination in OSF+OLK ( χ2 test, P = 0.007). OLK showed higher sensitivity and specificity than OSF, while the sensitivity and specificity of OSF+OLK are higher than OLK only and OSF only.

Conclusion: DNA image cytometry can be utilized as an adjunctive device for the initial detection of oral potentially malignant disorders that require further clinical management.

Keywords: DNA-Image Cytometry, DNA aneuploidy, Oral submucosal fibrosis, Oral Leukoplakia, oral potentially malignant disorder, epithelial dysplasia

Citation styles

APA
Li, H., Li, W., Gao, Y., Li, J., Zeng, X., Lin, J., Xie, X., Ling, T. (2024). DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders. Journal of Cancer, 15(5), 1182-1190. https://doi.org/10.7150/jca.91048.

ACS
Li, H.; Li, W.; Gao, Y.; Li, J.; Zeng, X.; Lin, J.; Xie, X.; Ling, T. DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders. J. Cancer 2024, 15 (5), 1182-1190. DOI: 10.7150/jca.91048.

NLM
Li H, Li W, Gao Y, Li J, Zeng X, Lin J, Xie X, Ling T. DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders. J Cancer 2024; 15(5):1182-1190. doi:10.7150/jca.91048. https://www.jcancer.org/v15p1182.htm

CSE
Li H, Li W, Gao Y, Li J, Zeng X, Lin J, Xie X, Ling T. 2024. DNA Image Cytometry for Screening the Carcinogenetic Risk of Oral Potential Malignant Disorders. J Cancer. 15(5):1182-1190.

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