The effectiveness and safety of rectal modular dissection for male middle and low rectal cancer after neoadjuvant chemoradiation therapy: the short-term outcome

Chen, Weijie; Liu, Yuxin; An, Yang; Qiu, Xiaoyuan; Zhou, Jiaolin; Cong, Lin; Lin, Guole

doi:10.7150/jca.91776

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J Cancer 2024; 15(5):1225-1233. doi:10.7150/jca.91776 This issue Cite

Research Paper

The effectiveness and safety of rectal modular dissection for male middle and low rectal cancer after neoadjuvant chemoradiation therapy: the short-term outcome

Weijie Chen, Yuxin Liu, Yang An, Xiaoyuan Qiu, Jiaolin Zhou, Lin Cong, Guole Lin^✉

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing 100730, P. R. China.

Citation:

Chen W, Liu Y, An Y, Qiu X, Zhou J, Cong L, Lin G. The effectiveness and safety of rectal modular dissection for male middle and low rectal cancer after neoadjuvant chemoradiation therapy: the short-term outcome. J Cancer 2024; 15(5):1225-1233. doi:10.7150/jca.91776. https://www.jcancer.org/v15p1225.htm

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Abstract

Background: The purpose of this study was to assess the efficacy and safety of rectal modular dissection (RMD) in male patients with middle and low rectal cancer. RMD is a technique used to guide the surgical procedure for rectal mobilization, with the ultimate goal of achieving total mesorectal excision. In order to evaluate the effectiveness of RMD, a single-center, non-inferiority randomized clinical trial was carried out.

Methods: Eligible patients were randomly assigned into two groups: the RMD group and the traditional rectal mobilization (TRM) group. Demographic characteristics, perioperative data and pathological results of the surgical specimens were collected for analysis. additionally, assessments of urogenital function and defecation function were conducted for all participants.

Results: A total of 103 patients (RMD group 53 patients and TRM group 50 patients) were included to analyzed. There were no significant differences in age, body mass index, ASA classification, and tumor characteristics between two groups. The RMD group had significantly lower blood loss (P = 0.00), shorter operative duration (P = 0.00), and shorter hospital stay (P = 0.04) compared to the TRM group. The complete rate of mesorectal excision was higher in the RMD group (98.1%) compared to the TRM group (86.0%, P = 0.02). In terms of functional outcomes, the RMD group had better evaluation scores for urethral function (IPSS score, P = 0.01), erectile function (IIEF-5 score, P = 0.00) and defecation function (LARS score, P = 0.00) at the one-year postoperative follow-up. The 1-year disease-free survival rate was similar between the two groups (P = 0.28).

Conclusions: These results suggest that RMD is an effective and safe approach for achieving total mesorectal excision while promoting better functional outcomes for patients.

The trial was registered in Chinese Clinical Trial Registry (ChiCTR2100052094).

Keywords: rectal cancer, total mesorectal excision, rectal mobilization, clinical trial

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APA

Chen, W., Liu, Y., An, Y., Qiu, X., Zhou, J., Cong, L., Lin, G. (2024). The effectiveness and safety of rectal modular dissection for male middle and low rectal cancer after neoadjuvant chemoradiation therapy: the short-term outcome. Journal of Cancer, 15(5), 1225-1233. https://doi.org/10.7150/jca.91776.

ACS

Chen, W.; Liu, Y.; An, Y.; Qiu, X.; Zhou, J.; Cong, L.; Lin, G. The effectiveness and safety of rectal modular dissection for male middle and low rectal cancer after neoadjuvant chemoradiation therapy: the short-term outcome. J. Cancer 2024, 15 (5), 1225-1233. DOI: 10.7150/jca.91776.

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CSE

Chen W, Liu Y, An Y, Qiu X, Zhou J, Cong L, Lin G. 2024. The effectiveness and safety of rectal modular dissection for male middle and low rectal cancer after neoadjuvant chemoradiation therapy: the short-term outcome. J Cancer. 15(5):1225-1233.

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