Dongguan Key Laboratory of Environmental Medicine, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, 523808. #Co-first authors.
✉ Corresponding authors: Jialong Chen, He Zhang; Dongguan Key Laboratory of Environmental Medicine, Affiliated Hospital of Guangdong Medical University, School of Public Health, Guangdong Medical University, Dongguan, 523808, P.R. China. Phone: +86-75922896573; E-mail: jialongcedu.cn; hzhang_2011com.More
Citation:
Chen J, Lu R, Peng Y, Lai Y, Cai Z, Zheng D, Xie A, Huang K, Liang C, Zhang H. MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy. J Cancer 2024; 15(5):1257-1270. doi:10.7150/jca.89485. https://www.jcancer.org/v15p1257.htm
Changes in calcium signalling are crucial for the development of glioma cells. Whether mitochondrial calcium balance is involved in glial cell development is still unknown. Mitochondrial Calcium Uniporter (MCU) plays an important role in regulating glioma progression. In this work, we found that MCU and p38 expression were positively correlated with glioma grade and the degree tumour progression. MCU increases glioma cell migration by upregulating p38. Furthermore, p38 promotes glioma progression by activating Transcription Factor EB (TFEB)-mediated autophagy. Thus, MCU promotes glioma cell migration by activating autophagy in a p38/TFEB pathway-dependent manner, which provides a theoretical basis for new therapeutic targets for gliomas.
Keywords: Autophagy, MCU, p38, Glioma, migration
Citation styles
APA
Chen, J., Lu, R., Peng, Y., Lai, Y., Cai, Z., Zheng, D., Xie, A., Huang, K., Liang, C., Zhang, H. (2024). MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy. Journal of Cancer, 15(5), 1257-1270. https://doi.org/10.7150/jca.89485.
ACS
Chen, J.; Lu, R.; Peng, Y.; Lai, Y.; Cai, Z.; Zheng, D.; Xie, A.; Huang, K.; Liang, C.; Zhang, H. MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy. J. Cancer 2024, 15 (5), 1257-1270. DOI: 10.7150/jca.89485.
NLM
Chen J, Lu R, Peng Y, Lai Y, Cai Z, Zheng D, Xie A, Huang K, Liang C, Zhang H. MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy. J Cancer 2024; 15(5):1257-1270. doi:10.7150/jca.89485. https://www.jcancer.org/v15p1257.htm
CSE
Chen J, Lu R, Peng Y, Lai Y, Cai Z, Zheng D, Xie A, Huang K, Liang C, Zhang H. 2024. MCU promotes the migration of glioma cells by activating p38 through TFEB-mediated autophagy. J Cancer. 15(5):1257-1270.
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